Imperial College London


Faculty of MedicineDepartment of Immunology and Inflammation

Reader in Rheumatology







Commonwealth BuildingHammersmith Campus





I am a Clinical Reader, Honorary Consultant Rheumatologist and a UKRI Future Leaders Fellow. My clinical and research interest is in the commonest form of arthritis, osteoarthritis. My particular focus is in the clinical and biological factors which predict outcome in high risk groups and the development of new tests and treatments for the condition.

Selected Publications

Journal Articles

Williams JAE, Chester-Jones M, Lowe CM, et al., 2022, Hormone replacement therapy (conjugated oestrogens plus bazedoxifene) for post-menopausal women with symptomatic hand osteoarthritis: primary report from the HOPE-e randomised, placebo-controlled, feasibility study, The Lancet Rheumatology, Vol:4, ISSN:2665-9913, Pages:E725-E737

Paskins Z, Farmer CE, Manning F, et al., 2022, Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method, The Lancet Rheumatology, Vol:4, ISSN:2665-9913, Pages:e635-e645

Garriga C, Goff M, Paterson E, et al., 2021, Clinical and molecular associations with outcomes at two years after acute knee injury: a longitudinal study in the Knee Injury Cohort at the Kennedy (KICK), The Lancet Rheumatology, Vol:3, ISSN:2665-9913, Pages:e648-e658

Watt FE, Wise EM, 2021, Osteoarthritis and associated comorbidities: new answers and more questions, Rheumatology, Vol:60, ISSN:1462-0324, Pages:3966-3968

Marian IR, Goff M, Williams JAE, et al., 2021, Hand Osteoarthritis: investigating Pain Effects of estrogen-containing therapy (HOPE-e): a protocol for a feasibility randomised placebo-controlled trial, Pilot and Feasibility Studies, Vol:7, ISSN:2055-5784, Pages:1-14

Mason D, Englund M, Watt FE, 2021, Prevention of posttraumatic osteoarthritis at the time of injury: Where are we now, and where are we going?, Journal of Orthopaedic Research, Vol:39, ISSN:0736-0266, Pages:1152-1163

Watt FE, 2021, Posttraumatic osteoarthritis: what have we learned to advance osteoarthritis?, Current Opinion in Rheumatology, Vol:33, ISSN:1040-8711, Pages:74-83

Watt FE, Blauwet MB, Fakhoury A, et al., 2019, Tropomyosin-related kinase A (TrkA) inhibition for the treatment of painful knee osteoarthritis: results from a randomized controlled phase 2a trial, Osteoarthritis and Cartilage, Vol:27, ISSN:1063-4584, Pages:1590-1598

Watt FE, Corp N, Kingsbury SR, et al., 2019, Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury, Osteoarthritis and Cartilage, Vol:27, ISSN:1063-4584, Pages:23-33

Kingsbury SR, Tharmanathan P, Keding A, et al., 2018, Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis A Randomized Trial, Annals of Internal Medicine, Vol:168, ISSN:0003-4819, Pages:385-+

Watt FE, 2018, Osteoarthritis biomarkers: year in review, Osteoarthritis and Cartilage, Vol:26, ISSN:1063-4584, Pages:312-318

Watt FE, Paterson E, Freidin A, et al., 2016, Acute molecular changes in synovial fluid following human knee injury: association with early clinical outcomes, Arthritis & Rheumatology, Vol:68, ISSN:2326-5205, Pages:2129-2140

Kingsbury SR, Corp N, Watt FE, et al., 2016, Harmonising data collection from osteoarthritis studies to enable stratification: recommendations on core data collection from an Arthritis Research UK clinical studies group, Rheumatology, Vol:55, ISSN:1462-0324, Pages:1394-1402

Watt FE, 2016, Hand osteoarthritis, menopause and menopausal hormone therapy, Maturitas, Vol:83, ISSN:0378-5122, Pages:13-18

Watt FE, Kennedy DL, Carlisle KE, et al., 2014, Night-time immobilization of the distal interphalangeal joint reduces pain and extension deformity in hand osteoarthritis, Rheumatology, Vol:53, ISSN:1462-0332, Pages:1142-1149

Watt FE, Ismail HM, Didangelos A, et al., 2013, Src and Fibroblast Growth Factor 2 Independently Regulate Signaling and Gene Expression Induced by Experimental Injury to Intact Articular Cartilage, Arthritis and Rheumatism, Vol:65, ISSN:0004-3591, Pages:397-407

Alexander S, Watt F, Sawaji Y, et al., 2007, Activin a is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-κB, Arthritis and Rheumatism, Vol:56, ISSN:0004-3591, Pages:3715-3725

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