Imperial College London
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DrFionaWatt

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Rheumatology
 
 
 
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Contact

 

f.watt

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Watt:2021:10.1097/BOR.0000000000000760,
author = {Watt, FE},
doi = {10.1097/BOR.0000000000000760},
journal = {Current Opinion in Rheumatology},
pages = {74--83},
title = {Posttraumatic osteoarthritis: what have we learned to advance osteoarthritis?},
url = {http://dx.doi.org/10.1097/BOR.0000000000000760},
volume = {33},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PURPOSE OF REVIEW: Current thinking in the study of posttraumatic osteoarthritis (PTOA) is overviewed: the osteoarthritis which follows acute joint injury. The review particularly highlights important publications in the last 18 months, also reflecting on key older literature, in terms of what have we have we learned and have yet to learn from PTOA, which can advance the osteoarthritis field as a whole. RECENT FINDINGS: PTOA is a mechanically driven disease, giving insight into mechanical drivers for osteoarthritis. A mechanosensitive molecular tissue injury response (which includes activation of pain, degradative and also repair pathways) is triggered by acute joint injury and seen in osteoarthritis. Imaging features of PTOA are highly similar to osteoarthritis, arguing against it being a different phenotype. The inflammatory pathways activated by injury contribute to early joint symptoms. However, later structural changes appear to be dissociated from traditional measures of synovial inflammation. SUMMARY: PTOA remains an important niche in which to understand processes underlying osteoarthritis and seek interventional targets. Whether PTOA has true molecular or clinical differences to osteoarthritis as a whole remains to be understood. This knowledge is important for a field where animal modelling of the disease relies heavily on the link between injury and osteoarthritis.
AU  - Watt,FE
DO  - 10.1097/BOR.0000000000000760
EP  - 83
PY  - 2021///
SN  - 1040-8711
SP  - 74
TI  - Posttraumatic osteoarthritis: what have we learned to advance osteoarthritis?
T2  - Current Opinion in Rheumatology
UR  - http://dx.doi.org/10.1097/BOR.0000000000000760
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33186246
UR  - https://journals.lww.com/co-rheumatology/Fulltext/2021/01000/Posttraumatic_osteoarthritis__what_have_we_learned.11.aspx
UR  - http://hdl.handle.net/10044/1/92047
VL  - 33
ER  -
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