Imperial College London
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DrFatemehGeranmayeh

Faculty of Medicine, Department of Brain Sciences

Clinical Research Fellow
 
 
 
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Contact

 

fatemeh.geranmayeh00

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zavaliangos-Petropulu:2022:10.1161/JAHA.121.025109,
author = {Zavaliangos-Petropulu, A and Lo, B and Donnelly, MR and Schweighofer, N and Lohse, K and Jahanshad, N and Barisano, G and Banaj, N and Borich, MR and Boyd, LA and Buetefisch, CM and Byblow, WD and Cassidy, JM and Charalambous, CC and Conforto, AB and DiCarlo, JA and Dula, AN and Egorova-Brumley, N and Etherton, MR and Feng, W and Fercho, KA and Geranmayeh, F and Hanlon, CA and Hayward, KS and Hordacre, B and Kautz, SA and Khlif, MS and Kim, H and Kuceyeski, A and Lin, DJ and Liu, J and Lotze, M and MacIntosh, BJ and Margetis, JL and Mohamed, FB and Piras, F and Ramos-Murguialday, A and Revill, KP and Roberts, PS and Robertson, AD and Schambra, HM and Seo, NJ and Shiroishi, MS and Stinear, CM and Soekadar, SR and Spalletta, G and Taga, M and Tang, WK and Thielman, GT and Vecchio, D and Ward, NS and Westlye, LT and Werden, E and Winstein, C and Wittenberg, GF and Wolf, SL and Wong, KA and Yu, C and Brodtmann, A and Cramer, SC and Thompson, PM and Liew, S-L},
doi = {10.1161/JAHA.121.025109},
journal = {Journal of the American Heart Association},
pages = {1--30},
title = {Chronic stroke sensorimotor impairment is related to smaller hippocampal volumes: an ENIGMA analysis},
url = {http://dx.doi.org/10.1161/JAHA.121.025109},
volume = {11},
year = {2022}
}
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TY  - JOUR
AB  - BackgroundPersistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upperlimb sensorimotor impairment. We investigated associations between nonlesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment.Methods and ResultsCrosssectional T1weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through MetaAnalysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMAUE (FuglMeyer Assessment of Upper Extremity). Robust mixedeffects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferronicorrected, P<0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. In exploratory analyses, we tested for a sensorimotor impairment and sex interaction and relationships between lesion volume, sensorimotor damage, and hippocampal volume. Greater sensorimotor impairment was significantly associated with ipsilesional (P=0.005; β=0.16) but not contralesional (P=0.96; β=0.003) hippocampal volume, independent of lesion volume and other covariates (P=0.001; β=0.26). Women showed progressively worsening sensorimotor impairment with smaller ipsilesional (P=0.008; β=−0.26) and contralesional (P=0.006; β=−0.27) hippocampal volumes compared with men. Hippocampal volume was associated with lesion size (P<0.001; β=−0.21) and extent of sensorimotor damage (P=0.003; β=−0.15).ConclusionsThe present study
AU  - Zavaliangos-Petropulu,A
AU  - Lo,B
AU  - Donnelly,MR
AU  - Schweighofer,N
AU  - Lohse,K
AU  - Jahanshad,N
AU  - Barisano,G
AU  - Banaj,N
AU  - Borich,MR
AU  - Boyd,LA
AU  - Buetefisch,CM
AU  - Byblow,WD
AU  - Cassidy,JM
AU  - Charalambous,CC
AU  - Conforto,AB
AU  - DiCarlo,JA
AU  - Dula,AN
AU  - Egorova-Brumley,N
AU  - Etherton,MR
AU  - Feng,W
AU  - Fercho,KA
AU  - Geranmayeh,F
AU  - Hanlon,CA
AU  - Hayward,KS
AU  - Hordacre,B
AU  - Kautz,SA
AU  - Khlif,MS
AU  - Kim,H
AU  - Kuceyeski,A
AU  - Lin,DJ
AU  - Liu,J
AU  - Lotze,M
AU  - MacIntosh,BJ
AU  - Margetis,JL
AU  - Mohamed,FB
AU  - Piras,F
AU  - Ramos-Murguialday,A
AU  - Revill,KP
AU  - Roberts,PS
AU  - Robertson,AD
AU  - Schambra,HM
AU  - Seo,NJ
AU  - Shiroishi,MS
AU  - Stinear,CM
AU  - Soekadar,SR
AU  - Spalletta,G
AU  - Taga,M
AU  - Tang,WK
AU  - Thielman,GT
AU  - Vecchio,D
AU  - Ward,NS
AU  - Westlye,LT
AU  - Werden,E
AU  - Winstein,C
AU  - Wittenberg,GF
AU  - Wolf,SL
AU  - Wong,KA
AU  - Yu,C
AU  - Brodtmann,A
AU  - Cramer,SC
AU  - Thompson,PM
AU  - Liew,S-L
DO  - 10.1161/JAHA.121.025109
EP  - 30
PY  - 2022///
SN  - 2047-9980
SP  - 1
TI  - Chronic stroke sensorimotor impairment is related to smaller hippocampal volumes: an ENIGMA analysis
T2  - Journal of the American Heart Association
UR  - http://dx.doi.org/10.1161/JAHA.121.025109
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000796637400012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.ahajournals.org/doi/10.1161/JAHA.121.025109
UR  - http://hdl.handle.net/10044/1/101494
VL  - 11
ER  -
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