Imperial College London
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ProfessorFrankKelly

Faculty of Medicine, School of Public Health

Battcock Chair in Community Health and Policy
 
 
 
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Contact

 

+44 (0)20 7594 8098 ext 48098frank.kelly Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kelly:2020:10.1098/rsta.2019.0322,
author = {Kelly, F and Fussell, J},
doi = {10.1098/rsta.2019.0322},
journal = {Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
pages = {1--15},
title = {Toxicity of airborne particles – established evidence, knowledge gaps and emerging areas of importance},
url = {http://dx.doi.org/10.1098/rsta.2019.0322},
volume = {378},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Epidemiological research has taught us a great deal about the health effects of airborne particulate matter  (PM)  particularly,  cardiorespiratory  effects  of  combustion-related  particles.  This  has  been matched  by  toxicological  research  to  define  underlying  mechanistic  pathways.To  keep  abreast  of the substantial challenges that air pollution continues to throw at us, requires yet more strides to be achieved.  For  example,  being  aware  of  the  most  toxic  components/sources  and  having  a  definitive idea  of  the  range  of  associated  disease  outcomes.  This  review  discusses  approaches  designed  to close some of these knowledge gaps. These include a focus on particles arising from non-exhaust PM at the roadside and microplastics – both of which are becoming more relevant in the light of a shift in PM composition in response to global  pressure to reduce combustion emissions. The  application of   hypothesis-free   approaches   in   both   mechanistic   studies   and   epidemiology   in   unveiling unexpected   relationships   and   generating   novel   insights   is   also   discussed.   Previous   work, strengthening the evidence for both the adverse effects and benefits of intervention tell us that the sooner  we  act  to  close  knowledge  gaps,  increase  awareness  and  develop  creative  solutions,  the sooner  we  can  reduce  the  public  health  burden  attributable  to  these  complex  and  insidious environmental pollutants.
AU  - Kelly,F
AU  - Fussell,J
DO  - 10.1098/rsta.2019.0322
EP  - 15
PY  - 2020///
SN  - 1364-503X
SP  - 1
TI  - Toxicity of airborne particles – established evidence, knowledge gaps and emerging areas of importance
T2  - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
UR  - http://dx.doi.org/10.1098/rsta.2019.0322
UR  - https://royalsocietypublishing.org/doi/10.1098/rsta.2019.0322
UR  - http://hdl.handle.net/10044/1/80875
VL  - 378
ER  -
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