Imperial College London

DrGavinBewick

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 3086g.bewick

 
 
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Location

 

6N5Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

24 results found

Dogan M, Brooks L, Bowe JE, Bewick GA, Frost G, Jones PM, Persaud SJet al., 2013, Expression and function of GPR43 in islets of Langerhans, DIABETIC MEDICINE, Vol: 30, Pages: 35-35, ISSN: 0742-3071

Journal article

Beale KEL, Gardiner JV, Bewick GA, Hostomska K, Patel NA, Hussain SS, Jayasena CN, Ebling FJP, Jethwa PH, Prosser HM, Lattanzi R, Negri L, Ghatei MA, Bloom SR, Dhillo WSet al., 2013, Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 168, Pages: 403-410, ISSN: 0007-1188

Journal article

Sam AH, Gunner DJ, King A, Persaud SJ, Brooks L, Hostomska K, Ford HE, Liu B, Ghatei MA, Bloom SR, Bewick GAet al., 2012, Selective Ablation of Peptide YY Cells in Adult Mice Reveals Their Role in Beta Cell Survival, GASTROENTEROLOGY, Vol: 143, Pages: 459-468, ISSN: 0016-5085

Journal article

Sam AH, Troke RC, Tan TM, Bewick GAet al., 2012, The role of the gut/brain axis in modulating food intake, NEUROPHARMACOLOGY, Vol: 63, Pages: 46-56, ISSN: 0028-3908

Journal article

Bewick GA, 2012, Bowels control brain: gut hormones and obesity, BIOCHEMIA MEDICA, Vol: 22, Pages: 283-297, ISSN: 1330-0962

Journal article

Boughton CK, Patterson M, Bewick GA, Tadross JA, Gardiner JV, Beale KEL, Chaudery F, Hunter G, Busbridge M, Leavy EM, Ghatei MA, Bloom SR, Murphy KGet al., 2010, Alarin stimulates food intake and gonadotrophin release in male rats, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 161, Pages: 601-613, ISSN: 0007-1188

Journal article

Gardiner JV, Beale KE, Roy D, Boughton CK, Bataveljic A, Campbell DC, Bewick GA, Patel NA, Patterson M, Leavy EM, Ghatei MA, Bloom SR, Dhillo WSet al., 2010, Cerebellin1 is a novel orexigenic peptide, DIABETES OBESITY & METABOLISM, Vol: 12, Pages: 883-890, ISSN: 1462-8902

Journal article

Gardiner JV, Campbell D, Patterson M, Kent A, Ghatei MA, Bloom SR, Bewick GAet al., 2010, The Hyperphagic Effect of Ghrelin Is Inhibited in Mice by a Diet High in Fat, GASTROENTEROLOGY, Vol: 138, Pages: 2468-U338, ISSN: 0016-5085

Journal article

Curtis AE, Murphy KG, Chaudhri OB, Ramachandran R, Young A-M, Waxman J, Nijher GMK, Bewick GA, Ghatei MA, Bloom SR, Dhillo WSet al., 2010, Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer, ONCOLOGY REPORTS, Vol: 23, Pages: 1729-1734, ISSN: 1021-335X

Journal article

Boughton CK, Patterson M, Tadross JA, Bewick GA, Gardiner JV, Ghatei MA, Bloom SR, Murphy KGet al., 2010, The Novel Neuropeptide Alarin Stimulates Food Intake and the Reproductive Axis in Male Rats., 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, ISSN: 0163-769X

Conference paper

Richardson E, Hussain SS, Counsell JR, Leavy E, Bewick GA, Bloom SR, Gardiner JVet al., 2010, The Role of Ventromedial Hypothalamic Glucose-Sensing Neurons during Glucoprivation., 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, ISSN: 0163-769X

Conference paper

Gardiner JV, Bataveljic A, Patel NA, Bewick GA, Roy D, Campbell D, Greenwood HC, Murphy KG, Hameed S, Jethwa PH, Ebling FJP, Vickers SP, Cheetham S, Ghatei MA, Bloom SR, Dhillo WSet al., 2009, Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake, Diabetes, Vol: 59, Pages: 397-406, ISSN: 0012-1797

OBJECTIVE Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis.RESEARCH DESIGN AND METHODS We investigated the effect of nutritional status on hypothalamic PK2 expression and effects of PK2 on the regulation of food intake by intracerebroventricular (ICV) injection of PK2 and anti-PK2 antibody. Subsequently, we investigated the potential mechanism of action by determining sites of neuronal activation after ICV injection of PK2, the hypothalamic site of action of PK2, and interaction between PK2 and other hypothalamic neuropeptides regulating energy homeostasis. To investigate PK2's potential as a therapeutic target, we investigated the effect of chronic administration in lean and obese mice.RESULTS Hypothalamic PK2 expression was reduced by fasting. ICV administration of PK2 to rats potently inhibited food intake, whereas anti-PK2 antibody increased food intake, suggesting that PK2 is an anorectic neuropeptide. ICV administration of PK2 increased c-fos expression in proopiomelanocortin neurons of the arcuate nucleus (ARC) of the hypothalamus. In keeping with this, PK2 administration into the ARC reduced food intake and PK2 increased the release of α-melanocyte–stimulating hormone (α-MSH) from ex vivo hypothalamic explants. In addition, ICV coadministration of the α-MSH antagonist agouti-related peptide blocked the anorexigenic effects of PK2. Chronic peripheral administration of PK2 reduced food and body weight in lean and obese mice.CONCLUSIONS This is the first report showing that PK2 has a role in appetite regulation and its anorectic effect is mediated partly via the melanocortin system.

Journal article

Patterson M, Murphy KG, Patel SR, Patel NA, Greenwood HC, Cooke JH, Campbell D, Bewick GA, Ghatei MA, Bloom SRet al., 2009, Hypothalamic Injection of Oxyntomodulin Suppresses Circulating Ghrelin-Like Immunoreactivity, ENDOCRINOLOGY, Vol: 150, Pages: 3513-3520, ISSN: 0013-7227

Journal article

Dhillo WS, Bewick GA, White NE, Gardiner JV, Thompson EL, Bataveljic A, Murphy KG, Roy D, Patel NA, Scutt JN, Armstrong A, Ghatei MA, Bloom SRet al., 2009, The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents, DIABETES OBESITY & METABOLISM, Vol: 11, Pages: 251-260, ISSN: 1462-8902

Journal article

Bewick GA, Kent A, Campbell D, Patterson M, Ghatei MA, Bloom SR, Gardiner JVet al., 2009, Mice With Hyperghrelinemia Are Hyperphagic and Glucose Intolerant and Have Reduced Leptin Sensitivity, Diabetes, Vol: 58, Pages: 840-846, ISSN: 0012-1797

Journal article

Parkinson JRC, Dhillo WS, Small CJ, Chaudhri OB, Bewick GA, Pritchard I, Moore S, Ghatei MA, Bloom SRet al., 2008, PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 294, Pages: E698-E708, ISSN: 0193-1849

Journal article

Thompson EL, Murphy KG, Patterson M, Bewick GA, Stamp GWH, Curtis AE, Cooke JH, Jethwa PH, Todd JF, Ghatei MA, Bloom SRet al., 2006, Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 291, Pages: E1074-E1082, ISSN: 0193-1849

Journal article

Murphy KG, Thompson EL, Patterson M, Bewick GA, Jethwa PH, Stamp GWH, Todd JF, Ghatei MA, Bloom SRet al., 2006, Continuous subcutaneous administration of kisspeptin-54 causes testicular degeneration in rats, 6th International Congress of Neuroendocrinology, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: 77-77, ISSN: 0091-3022

Conference paper

Dhillo WS, Gardiner JV, Castle L, Bewick GA, Smith KL, Meeran K, Todd JF, Ghatei MA, Bloom SRet al., 2005, Agouti related protein (AgRP) is upregulated in Cushing's syndrome, EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, Vol: 113, Pages: 602-606, ISSN: 0947-7349

Journal article

Bewick GA, Gardiner JV, Dhillo WS, Kent AS, White NE, Webster Z, Ghatei MA, Bloom SRet al., 2005, Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype, FASEB JOURNAL, Vol: 19, Pages: 1680-+, ISSN: 0892-6638

Journal article

Bewick GA, Dhillo WS, Darch SJ, Murphy KG, Gardiner JV, Jethwa PH, Kong WM, Ghatei MA, Bloom SRet al., 2005, Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release, ENDOCRINOLOGY, Vol: 146, Pages: 3526-3534, ISSN: 0013-7227

Journal article

Stanley SA, Murphy KG, Bewick GA, Kong WM, Opacka-Juffry J, Gardiner JV, Ghatei MA, Small CJ, Bloom SRet al., 2004, Regulation of rat pituitary cocaine- and amphetamine-regulated transcript (CART) by CRH and glucocorticoids, American Journal of Physiology Endocrinology and Metabolism, Vol: 287, Pages: E583-E590

Journal article

Dhillo WS, Small CJ, Jethwa PH, Russell SH, Gardiner JV, Bewick GA, Seth A, Murphy KG, Ghatei MA, Bloom SRet al., 2003, Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis, ENDOCRINOLOGY, Vol: 144, Pages: 1420-1425, ISSN: 0013-7227

Journal article

Dhillo WS, Small CJ, Gardiner JV, Bewick GA, Whitworth EJ, Jethwa PH, Seal LJ, Ghatei MA, Hinson JP, Bloom SRet al., 2003, Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 301, Pages: 102-107, ISSN: 0006-291X

Journal article

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