Publications
24 results found
Dogan M, Brooks L, Bowe JE, et al., 2013, Expression and function of GPR43 in islets of Langerhans, DIABETIC MEDICINE, Vol: 30, Pages: 35-35, ISSN: 0742-3071
Beale KEL, Gardiner JV, Bewick GA, et al., 2013, Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 168, Pages: 403-410, ISSN: 0007-1188
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- Citations: 25
Sam AH, Gunner DJ, King A, et al., 2012, Selective Ablation of Peptide YY Cells in Adult Mice Reveals Their Role in Beta Cell Survival, GASTROENTEROLOGY, Vol: 143, Pages: 459-468, ISSN: 0016-5085
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- Citations: 54
Sam AH, Troke RC, Tan TM, et al., 2012, The role of the gut/brain axis in modulating food intake, NEUROPHARMACOLOGY, Vol: 63, Pages: 46-56, ISSN: 0028-3908
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- Citations: 105
Bewick GA, 2012, Bowels control brain: gut hormones and obesity, BIOCHEMIA MEDICA, Vol: 22, Pages: 283-297, ISSN: 1330-0962
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- Citations: 15
Boughton CK, Patterson M, Bewick GA, et al., 2010, Alarin stimulates food intake and gonadotrophin release in male rats, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 161, Pages: 601-613, ISSN: 0007-1188
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- Citations: 35
Gardiner JV, Beale KE, Roy D, et al., 2010, Cerebellin1 is a novel orexigenic peptide, DIABETES OBESITY & METABOLISM, Vol: 12, Pages: 883-890, ISSN: 1462-8902
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- Citations: 8
Gardiner JV, Campbell D, Patterson M, et al., 2010, The Hyperphagic Effect of Ghrelin Is Inhibited in Mice by a Diet High in Fat, GASTROENTEROLOGY, Vol: 138, Pages: 2468-U338, ISSN: 0016-5085
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- Citations: 33
Curtis AE, Murphy KG, Chaudhri OB, et al., 2010, Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer, ONCOLOGY REPORTS, Vol: 23, Pages: 1729-1734, ISSN: 1021-335X
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- Citations: 16
Boughton CK, Patterson M, Tadross JA, et al., 2010, The Novel Neuropeptide Alarin Stimulates Food Intake and the Reproductive Axis in Male Rats., 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Richardson E, Hussain SS, Counsell JR, et al., 2010, The Role of Ventromedial Hypothalamic Glucose-Sensing Neurons during Glucoprivation., 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Gardiner JV, Bataveljic A, Patel NA, et al., 2009, Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake, Diabetes, Vol: 59, Pages: 397-406, ISSN: 0012-1797
OBJECTIVE Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis.RESEARCH DESIGN AND METHODS We investigated the effect of nutritional status on hypothalamic PK2 expression and effects of PK2 on the regulation of food intake by intracerebroventricular (ICV) injection of PK2 and anti-PK2 antibody. Subsequently, we investigated the potential mechanism of action by determining sites of neuronal activation after ICV injection of PK2, the hypothalamic site of action of PK2, and interaction between PK2 and other hypothalamic neuropeptides regulating energy homeostasis. To investigate PK2's potential as a therapeutic target, we investigated the effect of chronic administration in lean and obese mice.RESULTS Hypothalamic PK2 expression was reduced by fasting. ICV administration of PK2 to rats potently inhibited food intake, whereas anti-PK2 antibody increased food intake, suggesting that PK2 is an anorectic neuropeptide. ICV administration of PK2 increased c-fos expression in proopiomelanocortin neurons of the arcuate nucleus (ARC) of the hypothalamus. In keeping with this, PK2 administration into the ARC reduced food intake and PK2 increased the release of α-melanocyte–stimulating hormone (α-MSH) from ex vivo hypothalamic explants. In addition, ICV coadministration of the α-MSH antagonist agouti-related peptide blocked the anorexigenic effects of PK2. Chronic peripheral administration of PK2 reduced food and body weight in lean and obese mice.CONCLUSIONS This is the first report showing that PK2 has a role in appetite regulation and its anorectic effect is mediated partly via the melanocortin system.
Patterson M, Murphy KG, Patel SR, et al., 2009, Hypothalamic Injection of Oxyntomodulin Suppresses Circulating Ghrelin-Like Immunoreactivity, ENDOCRINOLOGY, Vol: 150, Pages: 3513-3520, ISSN: 0013-7227
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- Citations: 14
Dhillo WS, Bewick GA, White NE, et al., 2009, The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents, DIABETES OBESITY & METABOLISM, Vol: 11, Pages: 251-260, ISSN: 1462-8902
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- Citations: 39
Bewick GA, Kent A, Campbell D, et al., 2009, Mice With Hyperghrelinemia Are Hyperphagic and Glucose Intolerant and Have Reduced Leptin Sensitivity, Diabetes, Vol: 58, Pages: 840-846, ISSN: 0012-1797
Parkinson JRC, Dhillo WS, Small CJ, et al., 2008, PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 294, Pages: E698-E708, ISSN: 0193-1849
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- Citations: 31
Thompson EL, Murphy KG, Patterson M, et al., 2006, Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 291, Pages: E1074-E1082, ISSN: 0193-1849
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- Citations: 115
Murphy KG, Thompson EL, Patterson M, et al., 2006, Continuous subcutaneous administration of kisspeptin-54 causes testicular degeneration in rats, 6th International Congress of Neuroendocrinology, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: 77-77, ISSN: 0091-3022
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- Citations: 1
Dhillo WS, Gardiner JV, Castle L, et al., 2005, Agouti related protein (AgRP) is upregulated in Cushing's syndrome, EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, Vol: 113, Pages: 602-606, ISSN: 0947-7349
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- Citations: 6
Bewick GA, Gardiner JV, Dhillo WS, et al., 2005, Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype, FASEB JOURNAL, Vol: 19, Pages: 1680-+, ISSN: 0892-6638
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- Citations: 181
Bewick GA, Dhillo WS, Darch SJ, et al., 2005, Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release, ENDOCRINOLOGY, Vol: 146, Pages: 3526-3534, ISSN: 0013-7227
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- Citations: 36
Stanley SA, Murphy KG, Bewick GA, et al., 2004, Regulation of rat pituitary cocaine- and amphetamine-regulated transcript (CART) by CRH and glucocorticoids, American Journal of Physiology Endocrinology and Metabolism, Vol: 287, Pages: E583-E590
Dhillo WS, Small CJ, Jethwa PH, et al., 2003, Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis, ENDOCRINOLOGY, Vol: 144, Pages: 1420-1425, ISSN: 0013-7227
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- Citations: 42
Dhillo WS, Small CJ, Gardiner JV, et al., 2003, Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 301, Pages: 102-107, ISSN: 0006-291X
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- Citations: 42
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