Imperial College London

Professor George K. Christophides

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Infectious Diseases & Immunity



+44 (0)20 7594 5342g.christophides




6167Sir Alexander Fleming BuildingSouth Kensington Campus





Research in my lab focuses on vector-borne diseases, especially those transmitted by mosquitoes, such as malaria and various arboviral diseases. We are mostly interested in understanding how the mosquito immune system interacts with and controls infections with pathogens. Current research includes the characterisation of the mosquito midgut as an integrated system for the dissection of mucosal immune responses and homeostasis, the characterisation of the mosquito systemic immune response against malaria parasites and viruses, and the genetic modification of mosquitoes that are refractory to infection and can be used in population replacement strategies to reduce disease transmission using gene drive. We are also studying the molecular and cellular mechanisms facilitating pathogen development and replication within the vectors, especially how pathogens evade or endure the vector immune response.



Bailey AJ, Ukegbu VC, Giorgalli M, et al., 2023, Intracellular Plasmodium aquaporin 2 is required for sporozoite production in the mosquito vector and malaria transmission

Ukegbu CV, Gomes AR, Giorgalli M, et al., 2023, Reverse genetic screen identifies malaria parasite genes required for gametocyte-to-sporozoite development in its mosquito host

Neira M, Erguler K, Ahmady-Birgani H, et al., 2023, Climate change and human health in the Eastern Mediterranean and middle east: Literature review, research priorities and policy suggestions, Environmental Research, Vol:216, ISSN:0013-9351, Pages:1-23

Windbichler N, 2022, Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development, Science Advances, Vol:8, ISSN:2375-2548, Pages:1-9

Ellis D, Avraam GP, Hoermann A, et al., 2022, Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae, Plos Genetics, Vol:18, ISSN:1553-7404

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