Research in my lab focuses on vector-borne diseases, especially those transmitted by mosquitoes, such as malaria and various arboviral diseases. We are mostly interested in understanding how the mosquito immune system interacts with and controls infections with pathogens. Current research includes the characterisation of the mosquito midgut as an integrated system for the dissection of mucosal immune responses and homeostasis, the characterisation of the mosquito systemic immune response against malaria parasites and viruses, and the genetic modification of mosquitoes that are refractory to infection and can be used in population replacement strategies to reduce disease transmission using gene drive. We are also studying the molecular and cellular mechanisms facilitating pathogen development and replication within the vectors, especially how pathogens evade or endure the vector immune response.
et al., 2022, Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae, Plos Genetics, Vol:18, ISSN:1553-7404
et al., 2022, VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center, Nucleic Acids Research, Vol:50, ISSN:0305-1048, Pages:D898-D911
Paz S, Majeed A, Christophides GK, 2021, Climate change impacts on infectious diseases in the Eastern Mediterranean and the Middle East (EMME)-risks and recommendations, Climatic Change: an Interdisciplinary, International Journal Devoted to the Description, Causes and Implications of Climatic Change, Vol:169, ISSN:0165-0009, Pages:1-17
et al., 2021, Analysis of pir gene expression across the Plasmodium life cycle, Malaria Journal, Vol:20
et al., 2021, Assessment of <i>Plasmodium falciparum</i> infection and fitness of genetically modified <i>Anopheles gambiae</i> aimed at mosquito population replacement