Imperial College London

Professor George K. Christophides

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5342g.christophides

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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128 results found

Christophides GK, Crisanti A, 2013, Vector and vector-borne disease research: need for coherence, vision and strategic planning, PATHOGENS AND GLOBAL HEALTH, Vol: 107, Pages: 385-386, ISSN: 2047-7724

Journal article

Slater HC, Churcher TS, Christophides GK, Koella JC, Basanez M-Get al., 2013, PLASMODIUM-ANOPHELES INTERACTIONS: UNDERSTANDING WHAT'S BEST FOR THE PARASITE AND THE MOSQUITO, Publisher: MANEY PUBLISHING, Pages: 404-405, ISSN: 2047-7724

Conference paper

Rinker DC, Zhou X, Pitts RJ, AGC Consortium, Rokas A, Zwiebel LJet al., 2013, Antennal transcriptome profiles of anopheline mosquitoes reveal human host olfactory specialization in Anopheles gambiae, BMC Genomics, Vol: 14, ISSN: 1471-2164

BACKGROUND: Two sibling members of the Anopheles gambiae species complex display notable differences in female blood meal preferences. An. gambiae s.s. has a well-documented preference for feeding upon human hosts, whereas An. quadriannulatus feeds on vertebrate/mammalian hosts, with only opportunistic feeding upon humans. Because mosquito host-seeking behaviors are largely driven by the sensory modality of olfaction, we hypothesized that hallmarks of these divergent host seeking phenotypes will be in evidence within the transcriptome profiles of the antennae, the mosquito's principal chemosensory appendage. RESULTS: To test this hypothesis, we have sequenced antennal mRNA of non-bloodfed females from each species and observed a number of distinct quantitative and qualitative differences in their chemosensory gene repertoires. In both species, these gene families show higher rates of sequence polymorphisms than the overall rates in their respective transcriptomes, with potentially important divergences between the two species. Moreover, quantitative differences in odorant receptor transcript abundances have been used to model potential distinctions in volatile odor receptivity between the two sibling species of anophelines. CONCLUSION: This analysis suggests that the anthropophagic behavior of An. gambiae s.s. reflects the differential distribution of olfactory receptors in the antenna, likely resulting from a co-option and refinement of molecular components common to both species. This study improves our understanding of the molecular evolution of chemoreceptors in closely related anophelines and suggests possible mechanisms that underlie the behavioral distinctions in host seeking that, in part, account for the differential vectorial capacity of these mosquitoes.

Journal article

Akhouayri IG, Habtewold T, Christophides GK, 2013, Melanotic Pathology and Vertical Transmission of the Gut Commensal Elizabethkingia meningoseptica in the Major Malaria Vector Anopheles gambiae, PLOS ONE, Vol: 8, ISSN: 1932-6203

Journal article

Povelones M, Bhagavatula L, Yassine H, Tan LA, Upton LM, Osta MA, Christophides GKet al., 2013, The CLIP-domain serine protease homolog SPCLIP1 regulates complement recruitment to microbial surfaces in the malaria mosquito Anopheles gambiae, PLOS Pathogens, Vol: 9, ISSN: 1553-7366

The complement C3-like protein TEP1 of the mosquito Anopheles gambiae is required for defense against malaria parasites and bacteria. Two forms of TEP1 are present in the mosquito hemolymph, the full-length TEP1-F and the proteolytically processed TEP1cut that is part of a complex including the leucine-rich repeat proteins LRIM1 and APL1C. Here we show that the non-catalytic serine protease SPCLIP1 is a key regulator of the complement-like pathway. SPCLIP1 is required for accumulation of TEP1 on microbial surfaces, a reaction that leads to lysis of malaria parasites or triggers activation of a cascade culminating with melanization of malaria parasites and bacteria. We also demonstrate that the two forms of TEP1 have distinct roles in the complement-like pathway and provide the first evidence for a complement convertase-like cascade in insects analogous to that in vertebrates. Our findings establish that core principles of complement activation are conserved throughout the evolution of animals.

Journal article

Mitraka E, Stathopoulos S, Siden-Kiamos I, Christophides GK, Louis Cet al., 2013, Asaia accelerates larval development of Anopheles gambiae, PATHOGENS AND GLOBAL HEALTH, Vol: 107, Pages: 305-311, ISSN: 2047-7724

Journal article

Waldock J, Chandra NL, Lelieveld J, Proestos Y, Michael E, Christophides G, Parham PEet al., 2013, The role of environmental variables on Aedes albopictus biology and chikungunya epidemiology, PATHOGENS AND GLOBAL HEALTH, Vol: 107, Pages: 224-241, ISSN: 2047-7724

Journal article

Neafsey DE, Christophides GK, Collins FH, Emrich SJ, Fontaine MC, Gelbart W, Hahn MW, Howell PI, Kafatos FC, Lawson D, Muskavitch MAT, Waterhouse RM, Williams LJ, Besansky NJet al., 2013, The Evolution of the Anopheles 16 Genomes Project, G3-GENES GENOMES GENETICS, Vol: 3, Pages: 1191-1194, ISSN: 2160-1836

Journal article

Lombardo F, Ghani Y, Kafatos FC, Christophides GKet al., 2013, Comprehensive Genetic Dissection of the Hemocyte Immune Response in the Malaria Mosquito Anopheles gambiae, PLOS PATHOGENS, Vol: 9, ISSN: 1553-7374

Journal article

Waldock J, Olson KE, Christophides GK, 2012, Anopheles gambiae Antiviral Immune Response to Systemic O'nyong-nyong Infection, PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2727

Journal article

Midega JT, Smith DL, Olotu A, Mwangangi JM, Nzovu JG, Wambua J, Nyangweso G, Mbogo CM, Christophides GK, Marsh K, Bejon Pet al., 2012, Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya, NATURE COMMUNICATIONS, Vol: 3, ISSN: 2041-1723

Journal article

Megy K, Emrich SJ, Lawson D, Campbell D, Dialynas E, Hughes DST, Koscielny G, Louis C, MacCallum RM, Redmond SN, Sheehan A, Topalis P, Wilson Det al., 2012, VectorBase: improvements to a bioinformatics resource for invertebrate vector genomics, NUCLEIC ACIDS RESEARCH, Vol: 40, Pages: D729-D734, ISSN: 0305-1048

Journal article

MacCallum RM, Redmond SN, Christophides GK, 2011, An expression map for Anopheles gambiae, BMC GENOMICS, Vol: 12, ISSN: 1471-2164

Journal article

Mendes AM, Awono-Ambene PH, Nsango SE, Cohuet A, Fontenille D, Kafatos FC, Christophides GK, Morlais I, Vlachou Det al., 2011, Infection Intensity-Dependent Responses of Anopheles gambiae to the African Malaria Parasite Plasmodium falciparum, INFECTION AND IMMUNITY, Vol: 79, Pages: 4708-4715, ISSN: 0019-9567

Journal article

Christophides G, 2011, Contributions made by the Anopheles and Aedes Genome Projects, TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 16, Pages: 54-54, ISSN: 1360-2276

Journal article

Povelones M, Upton LM, Sala KA, Christophides GKet al., 2011, Structure-Function Analysis of the Anopheles gambiae LRIM1/APL1C Complex and its Interaction with Complement C3-Like Protein TEP1, PLOS PATHOGENS, Vol: 7, ISSN: 1553-7366

Journal article

White BJ, Lawniczak MKN, Cheng C, Coulibaly MB, Wilson MD, Sagnon N, Costantini C, Simard F, Christophides GK, Besansky NJet al., 2011, Adaptive divergence between incipient species of Anopheles gambiae increases resistance to Plasmodium, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 244-249, ISSN: 0027-8424

Journal article

Baum J, Billker O, Bousema T, Dinglasan R, McGovern V, Mota MM, Mueller I, Sinden Ret al., 2011, A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies, PLOS MEDICINE, Vol: 8, ISSN: 1549-1676

Journal article

Magnusson K, Mendes AM, Windbichler N, Papathanos P-A, Nolan T, Dottorini T, Rizzi E, Christophides GK, Crisanti Aet al., 2011, Transcription Regulation of Sex-Biased Genes during Ontogeny in the Malaria Vector Anopheles gambiae, Plos One, Vol: 6

Journal article

Churcher TS, Dawes EJ, Sinden RE, Christophides GK, Koella JC, Basanez M-Get al., 2010, Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions, MALARIA JOURNAL, Vol: 9, ISSN: 1475-2875

Journal article

Neafsey DE, Lawniczak MKN, Park DJ, Redmond SN, Coulibaly MB, Traore SF, Sagnon N, Costantini C, Johnson C, Wiegand RC, Collins FH, Lander ES, Wirth DF, Kafatos FC, Besansky NJ, Christophides GK, Muskavitch MATet al., 2010, SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes, SCIENCE, Vol: 330, Pages: 514-517, ISSN: 0036-8075

Journal article

Lawniczak MKN, Emrich SJ, Holloway AK, Regier AP, Olson M, White B, Redmond S, Fulton L, Appelbaum E, Godfrey J, Farmer C, Chinwalla A, Yang S-P, Minx P, Nelson J, Kyung K, Walenz BP, Garcia-Hernandez E, Aguiar M, Viswanathan LD, Rogers Y-H, Strausberg RL, Saski CA, Lawson D, Collins FH, Kafatos FC, Christophides GK, Clifton SW, Kirkness EF, Besansky NJet al., 2010, Widespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences, SCIENCE, Vol: 330, Pages: 512-514, ISSN: 0036-8075

Journal article

Bartholomay LC, Waterhouse RM, Mayhew GF, Campbell CL, Michel K, Zou Z, Ramirez JL, Das S, Alvarez K, Arensburger P, Bryant B, Chapman SB, Dong Y, Erickson SM, Karunaratne SHPP, Kokoza V, Kodira CD, Pignatelli P, Shin SW, Vanlandingham DL, Atkinson PW, Birren B, Christophides GK, Clem RJ, Hemingway J, Higgs S, Megy K, Ranson H, Zdobnov EM, Raikhel AS, Christensen BM, Dimopoulos G, Muskavitch MATet al., 2010, Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens, SCIENCE, Vol: 330, Pages: 88-90, ISSN: 0036-8075

Journal article

Waterhouse RM, Povelones M, Christophides GK, 2010, Sequence-structure-function relations of the mosquito leucine-rich repeat immune proteins, BMC GENOMICS, Vol: 11, ISSN: 1471-2164

Journal article

Cromer D, Christophides GK, Stark J, 2010, Hidden variable analysis of transcription factor cooperativity from microarray time courses, IET SYSTEMS BIOLOGY, Vol: 4, Pages: 131-U5561, ISSN: 1751-8849

Journal article

Bushell ESC, Ecker A, Schlegelmilch T, Goulding D, Dougan G, Sinden RE, Christophides GK, Kafatos FC, Vlachou Det al., 2009, Paternal Effect of the Nuclear Formin-like Protein MISFIT on Plasmodium Development in the Mosquito Vector, PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366

Journal article

Meister S, Agianian B, Turlure F, Relogio A, Morlais I, Kafatos FC, Christophides GKet al., 2009, Anopheles gambiae PGRPLC-Mediated Defense against Bacteria Modulates Infections with Malaria Parasites, PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366

Journal article

Megy K, Aarensburger P, Atkinson P, Besansky N, Bruggner R, Butler R, Campbell K, Christophides G, Christley S, Dialynas E, Emmert D, Hammond M, Hill C, Kennedy R, Lawson D, Lobo N, Madey G, Maccallum R, Redmond S, Russo S, Severson D, Stinson EO, Topalis P, Birney E, Gelbart W, Louis C, Kafatos F, Collins Fet al., 2009, VectorBase, Resource Center for Invertebrate Vectors of Human Pathogens, INFECTION GENETICS AND EVOLUTION, Vol: 9, Pages: 371-371, ISSN: 1567-1348

Journal article

Povelones M, Waterhouse RM, Kafatos FC, Christophides GKet al., 2009, Leucine-Rich Repeat Protein Complex Activates Mosquito Complement in Defense Against Plasmodium Parasites, SCIENCE, Vol: 324, Pages: 258-261, ISSN: 0036-8075

Journal article

Lawson D, Arensburger P, Atkinson P, Besansky NJ, Bruggner RV, Butler R, Campbell KS, Christophides GK, Christley S, Dialynas E, Hammond M, Hill CA, Konopinski N, Lobo NF, MacCallum RM, Madey G, Megy K, Meyer J, Redmond S, Severson DW, Stinson EO, Topalis P, Birney E, Gelbart WM, Kafatos FC, Louis C, Collins FHet al., 2009, VectorBase: a data resource for invertebrate vector genomics, NUCLEIC ACIDS RESEARCH, Vol: 37, Pages: D583-D587, ISSN: 0305-1048

Journal article

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