Imperial College London

Professor George K. Christophides

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5342g.christophides

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

128 results found

Muskavitch M, Neafsey D, Lawniczak M, Park D, Redmond S, Besansky N, Christophides G, Wiegand R, Collins F, Wirth D, Kafatos Fet al., 2008, DEVELOPMENT OF A HIGH-DENSITY SNP GENOTYPING ARRAY FOR THE VECTOR MOSQUITO ANOPHELES GAMBIAE, BY THE AGSNP CONSORTIUM, 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 316-316, ISSN: 0002-9637

Conference paper

Turlure F, Waldock J, Meister S, Kafatos F, Christophides Get al., 2008, The Anopheles REL1 signaling pathway is required for anti-fungal immunity and can reduce malaria infections, Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference, Publisher: BLACKWELL PUBLISHING, Pages: 277-277, ISSN: 1742-464X

Conference paper

Habtewold T, Povelones M, Blagborough AM, Christophides GKet al., 2008, Transmission blocking immunity in the malaria non-vector mosquito Anopheles quadriannulatus species A, Plos Pathogens, Vol: 4, ISSN: 1553-7374

Despite being phylogenetically very close to Anopheles gambiae, the major mosquito vector of human malaria in Africa,Anopheles quadriannulatus is thought to be a non-vector. Understanding the difference between vector and non-vectormosquitoes can facilitate development of novel malaria control strategies. We demonstrate that An. quadriannulatus islargely resistant to infections by the human parasite Plasmodium falciparum, as well as by the rodent parasite Plasmodiumberghei. By using genetics and reverse genetics, we show that resistance is controlled by quantitative heritable traits andmanifested by lysis or melanization of ookinetes in the mosquito midgut, as well as by killing of parasites at subsequentstages of their development in the mosquito. Genes encoding two leucine-rich repeat proteins, LRIM1 and LRIM2, and thethioester-containing protein, TEP1, are identified as essential in these immune reactions. Their silencing completelyabolishes P. berghei melanization and dramatically increases the number of oocysts, thus transforming An. quadriannulatusinto a highly permissive parasite host. We hypothesize that the mosquito immune system is an important cause of naturalrefractoriness to malaria and that utilization of this innate capacity of mosquitoes could lead to new methods to controltransmission of the disease.

Journal article

Mendes AM, Schlegelmilch T, Cohuet A, Awono-Ambene P, De Iorio M, Fontenille D, Morlais I, Christophides GK, Kafatos FC, Vlachou Det al., 2008, Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa, PLOS PATHOGENS, Vol: 4, ISSN: 1553-7366

Journal article

Jaubert-Possamai S, Le Trionnaire G, Bonhomme J, Christophides GK, Rispe C, Tagu Det al., 2007, Gene knockdown by RNAi in the pea aphid Acyrthosiphon pisum, BMC BIOTECHNOLOGY, Vol: 7

Journal article

Pindyurin AV, Moorman C, de Wit E, Belyakin SN, Belyaeva ES, Christophides GK, Kafatos FC, van Steensel B, Zhimulev IFet al., 2007, SUUR joins separate subsets of PcG, HP1 and B-type lamin targets in Drosophila, JOURNAL OF CELL SCIENCE, Vol: 120, Pages: 2344-2351, ISSN: 0021-9533

Journal article

Koutsos AC, Blass C, Meister S, Schmidt S, MacCallum RM, Soares MB, Collins FH, Benes V, Zdobnov E, Kafatos FC, Christophides GKet al., 2007, Life cycle transcriptome of the malaria mosquito anopheles gambiae and comparison with the fruitfly Drosophila melanogaster, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 11304-11309, ISSN: 0027-8424

Journal article

Waterhouse RM, Kriventseva EV, Meister S, Xi Z, Alvarez KS, Bartholomay LC, Barillas-Mury C, Bian G, Blandin S, Christensen BM, Dong Y, Jiang H, Kanost MR, Koutsos AC, Levashina EA, Li J, Ligoxygakis P, MacCallum RM, Mayhew GF, Mendes A, Michel K, Osta MA, Paskewitz S, Shin SW, Vlachou D, Wang L, Wei W, Zheng L, Zou Z, Severson DW, Raikhel AS, Kafatos FC, Dimopoulos G, Zdobnov EM, Christophides GKet al., 2007, Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes, SCIENCE, Vol: 316, Pages: 1738-1743, ISSN: 0036-8075

Journal article

Vontas J, David J-P, Nikou D, Hemingway J, Christophides GK, Louis C, Ranson Het al., 2007, Transcriptional analysis of insecticide resistance in Anopheles stephensi using cross-species microarray hybridization, INSECT MOLECULAR BIOLOGY, Vol: 16, Pages: 315-324, ISSN: 0962-1075

Journal article

Lawson D, Arensburger P, Atkinson P, Besansky NJ, Bruggner RV, Butler R, Campbell KS, Christophides GK, Christley S, Dialynas E, Emmert D, Hammond M, Hill CA, Kennedy RC, Lobo NF, MacCallum RM, Madey G, Megy K, Redmond S, Russo S, Severson DW, Stinson EO, Topalis P, Zdobnov EM, Birney E, Gelbart WM, Kafatos FC, Louis C, Collins FHet al., 2007, VectorBase: a home for invertebrate vectors of human pathogens, NUCLEIC ACIDS RESEARCH, Vol: 35, Pages: D503-D505, ISSN: 0305-1048

Journal article

Cohuet A, Osta MA, Morlais I, Awono-Ambene PH, Michel K, Simard F, Christophides GK, Fontenille D, Kafatos FCet al., 2006, Anopheles and Plasmodium: from laboratory models to natural systems in the field, EMBO REPORTS, Vol: 7, Pages: 1285-1289, ISSN: 1469-221X

Journal article

Christophides GK, Gouagna LC, Jacobs-Lorena M, James AA, Olson KEet al., 2006, What are relevant assays for refractoriness?, Conference on Bridging Laboratory and Field Research for Genetic Control of Disease Vectors, Publisher: SPRINGER, Pages: 165-+, ISSN: 1573-4544

Conference paper

James AA, Benedict MQ, Christophides GK, Jacobs-Lorena M, Olson KEet al., 2006, Evaluation of drive mechanisms (including transgenes and drivers) in different environmental conditions and genetic backgrounds, Conference on Bridging Laboratory and Field Research for Genetic Control of Disease Vectors, Publisher: SPRINGER, Pages: 149-+, ISSN: 1573-4544

Conference paper

Sim C, Hong YS, Vanlandingham DL, Harker BW, Christophides GK, Kafatos FC, Higgs S, Collins FHet al., 2005, Modulation of Anopheles gambiae gene expression in response to o'nyong-nyong virus infection, INSECT MOLECULAR BIOLOGY, Vol: 14, Pages: 475-481, ISSN: 0962-1075

Journal article

Vontas J, Blass C, Koutsos AC, David JP, Kafatos FC, Louis C, Hemingway J, Christophides GK, Ranson Het al., 2005, Gene expression in insecticide resistant and susceptible Anopheles gambiae strains constitutively or after insecticide exposure, INSECT MOLECULAR BIOLOGY, Vol: 14, Pages: 509-521, ISSN: 0962-1075

Journal article

Meister S, Kanzok SM, Zheng XL, Luna C, Li TR, Hoa NT, Clayton JR, White KP, Kafatos FC, Christophides GK, Zheng LBet al., 2005, Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 102, Pages: 11420-11425, ISSN: 0027-8424

Journal article

Vlachou D, Schlegelmilch T, Christophides GK, Kafatos FCet al., 2005, Functional genomic analysis of midgut epithelial responses in Anopheles during Plasmodium invasion, CURRENT BIOLOGY, Vol: 15, Pages: 1185-1195, ISSN: 0960-9822

Journal article

Belyakin SN, Christophides GK, Alekseyenko AA, Kriventseva EV, Belyaeva ES, Nanayev RA, Makunin IV, Kafatos FC, Zhimulev IFet al., 2005, Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 102, Pages: 8269-8274, ISSN: 0027-8424

Journal article

Kriventseva EV, Koutsos AC, Blass C, Kafatos FC, Christophides GK, Zdobnov EMet al., 2005, AnoEST: Toward A-gambiae functional genomics, GENOME RESEARCH, Vol: 15, Pages: 893-899, ISSN: 1088-9051

Journal article

Christophides GK, 2005, Transgenic mosquitoes and malaria transmission, CELLULAR MICROBIOLOGY, Vol: 7, Pages: 325-333, ISSN: 1462-5814

Journal article

Hall N, Karras M, Raine JD, Carlton JM, Kooij TWA, Berriman M, Florens L, Janssen CS, Pain A, Christophides GK, James K, Rutherford K, Harris B, Harris D, Churcher C, Quail MA, Ormond D, Doggett J, Trueman HE, Mendoza J, Bidwell SL, Rajandream MA, Carucci DJ, Yates JR, Kafatos FC, Janse CJ, Barrell B, Turner CMR, Waters AP, Sinden REet al., 2005, A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses, SCIENCE, Vol: 307, Pages: 82-86, ISSN: 0036-8075

Journal article

Christophides G, Meister S, Koutsos A, Blass C, Kanzok S, Vlachou D, Schlegelmilch T, Osta M, Zheng L, Kafatos Fet al., 2005, Systems biology of the Anopheles gainbiae innate immunity [MIM-GC-22590], ACTA TROPICA, Vol: 95, Pages: S44-S45, ISSN: 0001-706X

Journal article

Meister S, Koutsos AC, Christophides GK, 2004, The Plasmodium parasite - a 'new' challenge for insect innate immunity, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 34, Pages: 1473-1482, ISSN: 0020-7519

Journal article

Osta MA, Christophides GK, Vlachou D, Kafatos FCet al., 2004, Innate immunity in the malaria vector Anopheles gambiae: comparative and functional genomics, JOURNAL OF EXPERIMENTAL BIOLOGY, Vol: 207, Pages: 2551-2563, ISSN: 0022-0949

Journal article

Christophides GK, Vlachou D, Kafatos FC, 2004, Comparative and functional genomics of the innate immune system in the malaria vector Anopheles gambiae, IMMUNOLOGICAL REVIEWS, Vol: 198, Pages: 127-148, ISSN: 0105-2896

Journal article

Osta MA, Christophides GK, Kafatos FC, 2004, Effects of mosquito genes on Plasmodium development, SCIENCE, Vol: 303, Pages: 2030-2032, ISSN: 0036-8075

Journal article

Komitopoulou K, Christophides GK, Kalosaka K, Chrysanthis G, Theodoraki MA, Savakis C, Zacharopoulou A, Mintzas ACet al., 2004, Medfly promoters relevant to the sterile insect technique, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol: 34, Pages: 149-157, ISSN: 0965-1748

Journal article

Kumar S, Christophides GK, Cantera R, Charles B, Han YS, Meister S, Dimopoulos G, Kafatos FC, Barillas-Mury Cet al., 2003, The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 14139-14144, ISSN: 0027-8424

Journal article

Holt RA, Subramanian GM, Halpern A, Sutton GG, Charlab R, Nusskern DR, Wincker P, Clark AG, Ribeiro JMC, Wides R, Salzberg SL, Loftus B, Yandell M, Majoros WH, Rusch DB, Lai ZW, Kraft CL, Abril JF, Anthouard V, Arensburger P, Atkinson PW, Baden H, de Berardinis V, Baldwin D, Benes V, Biedler J, Blass C, Bolanos R, Boscus D, Barnstead M, Cai S, Center A, Chatuverdi K, Christophides GK, Chrystal MA, Clamp M, Cravchik A, Curwen V, Dana A, Delcher A, Dew I, Evans CA, Flanigan M, Grundschober-Freimoser A, Friedli L, Gu ZP, Guan P, Guigo R, Hillenmeyer ME, Hladun SL, Hogan JR, Hong YS, Hoover J, Jaillon O, Ke ZX, Kodira C, Kokoza E, Koutsos A, Letunic I, Levitsky A, Liang Y, Lin JJ, Lobo NF, Lopez JR, Malek JA, McIntosh TC, Meister S, Miller J, Mobarry C, Mongin E, Murphy SD, O'Brochta DA, Pfannkoch C, Qi R, Regier MA, Remington K, Shao HG, Sharakhova MV, Sitter CD, Shetty J, Smith TJ, Strong R, Sun JT, Thomasova D, Ton LQ, Topalis P, Tu ZJ, Unger MF, Walenz B, Wang AH, Wang J, Wang M, Wang XL, Woodford KJ, Wortman JR, Wu M, Yao A, Zdobnov EM, Zhang HY, Zhao Q, Zhao SY, Zhu SPC, Zhimulev I, Coluzzi M, della Torre A, Roth CW, Louis C, Kalush F, Mural RJ, Myers EW, Adams MD, Smith HO, Broder S, Gardner MJ, Fraser CM, Birney E, Bork P, Brey PT, Venter JC, Weissenbach J, Kafatos FC, Collins FH, Hoffman SLet al., 2002, The genome sequence of the malaria mosquito Anopheles gambiae, SCIENCE, Vol: 298, Pages: 129-+, ISSN: 0036-8075

Journal article

Zdobnov EM, von Mering C, Letunic I, Torrents D, Suyama M, Copley RR, Christophides GK, Thomasova D, Holt RA, Subramanian GM, Mueller HM, Dimopoulos G, Law JH, Wells MA, Birney E, Charlab R, Halpern AL, Kokoza E, Kraft CL, Lai ZW, Lewis S, Louis C, Barillas-Mury C, Nusskern D, Rubin GM, Salzberg SL, Sutton GG, Topalis P, Wides R, Wincker P, Yandell M, Collins FH, Ribeiro J, Gelbart WM, Kafatos FC, Bork Pet al., 2002, Comparative genome and proteome analysis of anopheles gambiae and Drosophila melanogaster, SCIENCE, Vol: 298, Pages: 149-159, ISSN: 0036-8075

Journal article

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