Imperial College London

Professor George K. Christophides

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5342g.christophides

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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128 results found

Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, Muller HM, Osta MA, Paskewitz SM, Reichhart JM, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu JN, Zheng LB, Bork P, Kafatos FCet al., 2002, Immunity-related genes and gene families in Anopheles gambiae, SCIENCE, Vol: 298, Pages: 159-165, ISSN: 0036-8075

Journal article

Dimopoulos G, Christophides GK, Meister S, Schultz J, White KP, Barillas-Mury C, Kafatos FCet al., 2002, Genome expression analysis of Anopheles gambiae: Responses to injury, bacterial challenge, and malaria infection, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 8814-8819, ISSN: 0027-8424

Journal article

Christophides GK, Savakis C, Mintzas AC, Komitopoulou Ket al., 2002, Expression and function of the Drosophila melanogaster ADH in male Ceratitis capitata adults: a potential strategy for medfly genetic sexing based on gene-transfer technology (vol 10, pg 249, 2001), INSECT MOLECULAR BIOLOGY, Vol: 11, Pages: 115-115, ISSN: 0962-1075

Journal article

Christophides GK, Savakis C, Mintzas AC, Komitopoulou Ket al., 2001, Expression and function of the Drosophila melanogaster ADH in male Ceratitis capitata adults: a potential strategy for medfly genetic sexing based on gene-transfer technology, INSECT MOLECULAR BIOLOGY, Vol: 10, Pages: 249-254, ISSN: 0962-1075

Journal article

Christophides GK, Livadaras I, Savakis C, Komitopoulou Ket al., 2000, Two medfly promoters that have originated by recent gene duplication drive distinct sex, tissue and temporal expression patterns, GENETICS, Vol: 156, Pages: 173-182, ISSN: 0016-6731

Journal article

Christophides GK, Mintzas AC, Komitopoulou K, 2000, Organization, evolution and expression of a multigene family encoding putative members of the odourant binding protein family in the medfly Ceratitis capitata, INSECT MOLECULAR BIOLOGY, Vol: 9, Pages: 185-195, ISSN: 0962-1075

Journal article

Lygerou Z, Christophides G, Seraphin B, 1999, A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing, MOLECULAR AND CELLULAR BIOLOGY, Vol: 19, Pages: 2008-2020, ISSN: 0270-7306

Journal article

Ferdous Z, Fuchs S, Behrends V, Trasanidis N, Vlachou D, Christophides GKet al., Anopheles coluzzii stearoyl-CoA desaturase is essential for adult female survival and reproduction upon blood feeding

<jats:title>Abstract</jats:title><jats:p>Vitellogenesis and oocyte maturation require anautogenous female <jats:italic>Anopheles</jats:italic> mosquitoes to obtain a bloodmeal from a vertebrate host. The bloodmeal is rich in proteins that are readily broken down into amino acids in the midgut lumen and absorbed by the midgut epithelial cells where they are converted into lipids and then transported to other tissues including ovaries. The stearoyl-CoA desaturase (SCD) plays a pivotal role in this process by converting saturated (SFAs) to unsaturated (UFAs) fatty acids; the latter being essential for maintaining cell membrane fluidity amongst other housekeeping functions. Here, we report the functional and phenotypic characterization of SCD1 in the malaria vector mosquito <jats:italic>Anopheles coluzzii</jats:italic>. We show that RNA interference (RNAi) silencing of <jats:italic>SCD1</jats:italic> and administration of sterculic acid (SA), a small molecule inhibitor of SCD1, significantly impact on the survival and reproduction of female mosquitoes following blood feeding. Microscopic observations reveal that the mosquito thorax is quickly filled with blood, a phenomenon likely caused by the collapse of midgut epithelial cell membranes, and that epithelial cells are depleted of lipid droplets and oocytes fail to mature. Transcriptional profiling shows that genes involved in protein, lipid and carbohydrate metabolism and immunity-related genes are the most affected by <jats:italic>SCD1</jats:italic> knock down (KD) in blood-fed mosquitoes. Metabolic profiling reveals that these mosquitoes exhibit increased amounts of saturated fatty acids and TCA cycle intermediates, highlighting the biochemical framework by which the <jats:italic>SCD1</jats:italic> KD phenotype manifests as a result of a detrimental metabolic syndrome. Accumulation of SFAs is also the likely cause of the potent immune respo

Journal article

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