Imperial College London

Professor George K. Christophides

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5342g.christophides

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{James:2020:10.1089/vbz.2019.2606,
author = {James, SL and Marshall, JM and Christophides, GK and Okumu, FO and Nolan, T},
doi = {10.1089/vbz.2019.2606},
journal = {Vector-Borne and Zoonotic Diseases},
pages = {237--251},
title = {Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing},
url = {http://dx.doi.org/10.1089/vbz.2019.2606},
volume = {20},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Mosquitoes containing gene drive systems are being developed as complementary tools to prevent transmission of malaria and other mosquito-borne diseases. As with any new tool, decision makers and other stakeholders will need to balance risks (safety) and benefits (efficacy) when considering the rationale for testing and deploying gene drive-modified mosquito products. Developers will benefit from standards for judging whether an investigational gene drive product meets acceptability criteria for advancing to field trials. Such standards may be formalized as preferred product characteristics and target product profiles, which describe the desired attributes of the product category and of a particular product, respectively. This report summarizes discussions from two scientific workshops aimed at identifying efficacy and safety characteristics that must be minimally met for an investigational gene drive-modified mosquito product to be deemed viable to move from contained testing to field release and the data that will be needed to support an application for first field release.
AU - James,SL
AU - Marshall,JM
AU - Christophides,GK
AU - Okumu,FO
AU - Nolan,T
DO - 10.1089/vbz.2019.2606
EP - 251
PY - 2020///
SN - 1530-3667
SP - 237
TI - Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing
T2 - Vector-Borne and Zoonotic Diseases
UR - http://dx.doi.org/10.1089/vbz.2019.2606
UR - https://www.ncbi.nlm.nih.gov/pubmed/32155390
UR - https://www.liebertpub.com/doi/10.1089/vbz.2019.2606
UR - http://hdl.handle.net/10044/1/77643
VL - 20
ER -