Imperial College London

Professor George K. Christophides

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
//

Contact

 

+44 (0)20 7594 5342g.christophides

 
 
//

Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Gendrin:2016:10.1038/srep38230,
author = {Gendrin, MEM and Christophides and Linenberg and Inbar},
doi = {10.1038/srep38230},
journal = {Scientific Reports},
title = {Larval diet affects mosquito development and permissiveness to Plasmodium infection},
url = {http://dx.doi.org/10.1038/srep38230},
volume = {6},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The larval stages of malaria vector mosquitoes develop in water pools, feeding mostly on microorganisms and environmental detritus. Richness in the nutrient supply to larvae influences the development and metabolism of larvae and adults. Here, we investigated the effects of larval diet on the development, microbiota content and permissiveness to Plasmodium of Anopheles coluzzii. We tested three fish diets often used to rear mosquitoes in the laboratory, including two pelleted diets, Dr. Clarke’s Pool Pellets and Nishikoi Fish Pellets, and one flaked diet, Tetramin Fish-Flakes. Larvae grow and develop faster and produce bigger adults when feeding on both types of pellets compared with flakes. This correlates with a higher microbiota load in pellet-fed larvae, in agreement with the known positive effect of the microbiota on mosquito development. Larval diet also significantly influences the prevalence and intensity of Plasmodium berghei infection in adults, whereby Nishikoi Fish Pellets-fed larvae develop into adults that are highly permissive to parasites and survive longer after infection. This correlates with a lower amount of Enterobacteriaceae in the midgut microbiota. Together, our results shed light on the influence of larval feeding on mosquito development, microbiota and vector competence; they also provide useful data for mosquito rearing.
AU - Gendrin,MEM
AU - Christophides
AU - Linenberg
AU - Inbar
DO - 10.1038/srep38230
PY - 2016///
SN - 2045-2322
TI - Larval diet affects mosquito development and permissiveness to Plasmodium infection
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/srep38230
UR - http://hdl.handle.net/10044/1/42443
VL - 6
ER -