Imperial College London

Professor George K. Christophides

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5342g.christophides

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gendrin:2017:10.1159/000452797,
author = {Gendrin, MEM and Turlure, F and Rodgers, FH and Cohuet, A and Morlais, I and Christophides, GK},
doi = {10.1159/000452797},
journal = {Journal of Innate Immunity},
pages = {333--342},
title = {The peptidoglycan recognition proteins PGRPLA and PGRPLB regulate Anopheles immunity to bacteria and affect infection by Plasmodium},
url = {http://dx.doi.org/10.1159/000452797},
volume = {9},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Peptidoglycan recognition proteins (PGRPs) form a family of immune regulators that is conserved from insects to mammals. In the malaria vector mosquito Anophelescoluzzii, the peptidoglycan receptor PGRPLC activates the Imd pathway limiting both the microbiota load and Plasmodiuminfection. Here, we carried out an RNAi screen to examine the role of all seven Anopheles PGRPs in infections with Plasmodium berghei and Plasmodium falciparum. We show that, in addition to PGRPLC, PGRPLA and PGRPS2/S3 also participate in antiparasitic defenses, and that PGRPLB promotes mosquito permissiveness to P. falciparum. We also demonstrate that following a mosquito blood feeding, which promotes growth of the gut microbiota, PGRPLA and PGRPLB positively and negatively regulate the activation of the Imd pathway, respectively. Our data demonstrate that PGRPs are important regulators of the mosquito epithelial immunity and vector competence.
AU - Gendrin,MEM
AU - Turlure,F
AU - Rodgers,FH
AU - Cohuet,A
AU - Morlais,I
AU - Christophides,GK
DO - 10.1159/000452797
EP - 342
PY - 2017///
SN - 1662-8128
SP - 333
TI - The peptidoglycan recognition proteins PGRPLA and PGRPLB regulate Anopheles immunity to bacteria and affect infection by Plasmodium
T2 - Journal of Innate Immunity
UR - http://dx.doi.org/10.1159/000452797
UR - http://hdl.handle.net/10044/1/42573
VL - 9
ER -