Imperial College London
Alternate

Professor George K. Christophides

Faculty of Natural Sciences, Department of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5342g.christophides

 
 
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Location

 

6165Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Hoermann:2022:10.1101/2022.02.15.480588,
author = {Hoermann, A and Habtewold, T and Selvaraj, P and Del, Corsano G and Capriotti, P and Inghilterra, MG and Kebede, TM and Christophides, GK and Windbichler, N},
doi = {10.1101/2022.02.15.480588},
title = {Gene Drive Mosquitoes Can Aid Malaria Elimination by Retarding Plasmodium Sporogonic Development},
url = {http://dx.doi.org/10.1101/2022.02.15.480588},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Abstract</jats:title><jats:p>Gene drives hold promise for the genetic control of malaria vectors. The development of vector population modification strategies hinges on the availability of effector mechanisms impeding parasite development in transgenic mosquitoes. We augmented a midgut gene of the malaria mosquito <jats:italic>Anopheles gambiae</jats:italic> to secrete two exogenous antimicrobial peptides, Magainin 2 and Melittin. This small genetic modification, capable of efficient non-autonomous gene drive, hampers oocyst development in both <jats:italic>Plasmodium falciparum</jats:italic> and <jats:italic>Plasmodium berghei</jats:italic>. It delays the release of infectious sporozoites while it simultaneously reduces the lifespan of homozygous female transgenic mosquitoes. Modeling the spread of this modification using a large-scale agent-based model of malaria epidemiology reveals that it can break the cycle of disease transmission across a range of endemic settings.</jats:p><jats:sec><jats:title>One sentence summary</jats:title><jats:p>We developed a gene drive effector that retards <jats:italic>Plasmodium</jats:italic> development in transgenic <jats:italic>Anopheles gambiae</jats:italic> mosquitoes via the expression of antimicrobial peptides in the midgut and which is predicted to eliminate malaria under a range of transmission scenarios.</jats:p></jats:sec>
AU  - Hoermann,A
AU  - Habtewold,T
AU  - Selvaraj,P
AU  - Del,Corsano G
AU  - Capriotti,P
AU  - Inghilterra,MG
AU  - Kebede,TM
AU  - Christophides,GK
AU  - Windbichler,N
DO  - 10.1101/2022.02.15.480588
PY  - 2022///
TI  - Gene Drive Mosquitoes Can Aid Malaria Elimination by Retarding Plasmodium Sporogonic Development
UR  - http://dx.doi.org/10.1101/2022.02.15.480588
ER  -
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