Imperial College London
Alternate

Professor George K. Christophides

Faculty of Natural Sciences, Department of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5342g.christophides

 
 
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Location

 

6165Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gendrin:2016:ofid/ofw074,
author = {Gendrin, MEM and Yerbanga, RS and Ouedrogo, JB and Lefèvre, T and Cohuet, A and Christophides, GK},
doi = {ofid/ofw074},
journal = {Open Forum Infectious Diseases},
title = {Differential effects of azithromycin, doxycycline and co-trimoxazole in ingested blood on the vectorial capacity of malaria mosquitoes},
url = {http://dx.doi.org/10.1093/ofid/ofw074},
volume = {3},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background The gut microbiota of malaria vector mosquitoes grows after a blood meal and limits Plasmodium infection. We previously showed that penicillin and streptomycin in the ingested blood affect bacterial growth and positively impact mosquito survival and permissiveness to Plasmodium. Here, we examine the effects of doxycycline, azithromycin and co-trimoxazole. All three antibiotics are used in mass-drug administration programs and have antimicrobial activities against bacteria and various stages of malaria parasites.MethodsThe effects of blood meal supplementation with antibiotics on the mosquito microbiota, lifespan and permissiveness to Plasmodium falciparum were assessed. ResultsIngestion of any of the three antibiotics significantly affected the mosquito microbiota. Azithromycin decreased P. falciparum infection load and mosquito lifespan, while at high concentrations, doxycycline increased P. falciparum infection load. Co-trimoxazole negatively impacted infection intensity but had no reproducible effect on mosquito lifespan.ConclusionsOur data suggest that the overall effect of antibiotic treatment on parameters critical for mosquito vectorial capacity is drug-specific. The negative effect of azithromycin on malaria transmission is consistent with current efforts for disease elimination, while additional, larger scale investigations are required before conclusions can be drawn about doxycycline.
AU  - Gendrin,MEM
AU  - Yerbanga,RS
AU  - Ouedrogo,JB
AU  - Lefèvre,T
AU  - Cohuet,A
AU  - Christophides,GK
DO  - ofid/ofw074
PY  - 2016///
SN  - 2328-8957
TI  - Differential effects of azithromycin, doxycycline and co-trimoxazole in ingested blood on the vectorial capacity of malaria mosquitoes
T2  - Open Forum Infectious Diseases
UR  - http://dx.doi.org/10.1093/ofid/ofw074
UR  - http://hdl.handle.net/10044/1/30667
VL  - 3
ER  -
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