Imperial College London
Alternate

Professor George K. Christophides

Faculty of Natural Sciences, Department of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5342g.christophides

 
 
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Location

 

6165Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gendrin:2016:10.1038/srep38230,
author = {Gendrin, MEM and Christophides and Linenberg and Inbar},
doi = {10.1038/srep38230},
journal = {Scientific Reports},
title = {Larval diet affects mosquito development and permissiveness to Plasmodium infection},
url = {http://dx.doi.org/10.1038/srep38230},
volume = {6},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The   larval   stages   of   malaria   vector   mosquitoes   develop   in   water   pools,   feeding   mostly   on   microorganisms and environmental detritus. Richness in the nutrient supply to larvae influences the development and metabolism of larvae and adults. Here, we investigated the effects of larval diet on the  development,  microbiota  content  and  permissiveness  to  Plasmodium of Anopheles  coluzzii.  We  tested three fish diets often used to rear mosquitoes in the laboratory, including two pelleted diets, Dr.  Clarke’s  Pool  Pellets  and  Nishikoi  Fish  Pellets,  and  one  flaked  diet,  Tetramin  Fish-Flakes.  Larvae  grow and develop faster and produce bigger adults when feeding on both types of pellets compared with flakes. This correlates with a higher microbiota load in pellet-fed larvae, in agreement with the known  positive  effect  of  the  microbiota  on  mosquito  development.  Larval  diet  also  significantly  influences the prevalence and intensity of Plasmodium berghei infection in adults, whereby Nishikoi Fish Pellets-fed larvae develop into adults that are highly permissive to parasites and survive longer after infection. This correlates with a lower amount of Enterobacteriaceae in the midgut microbiota. Together,  our  results  shed  light  on  the  influence  of  larval  feeding  on  mosquito  development,  microbiota and vector competence; they also provide useful data for mosquito rearing.
AU  - Gendrin,MEM
AU  - Christophides
AU  - Linenberg
AU  - Inbar
DO  - 10.1038/srep38230
PY  - 2016///
SN  - 2045-2322
TI  - Larval diet affects mosquito development and permissiveness to Plasmodium infection
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/srep38230
UR  - http://hdl.handle.net/10044/1/42443
VL  - 6
ER  -
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