Imperial College London
Alternate

Professor George K. Christophides

Faculty of Natural Sciences, Department of Life Sciences

Professor of Infectious Diseases & Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5342g.christophides

 
 
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Location

 

6165Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gendrin:2017:10.1159/000452797,
author = {Gendrin, MEM and Turlure, F and Rodgers, FH and Cohuet, A and Morlais, I and Christophides, GK},
doi = {10.1159/000452797},
journal = {Journal of Innate Immunity},
pages = {333--342},
title = {The peptidoglycan recognition proteins PGRPLA and PGRPLB regulate Anopheles immunity to bacteria and affect infection by Plasmodium},
url = {http://dx.doi.org/10.1159/000452797},
volume = {9},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Peptidoglycan recognition proteins (PGRPs) form a family of immune regulators that is conserved from  insects  to  mammals.  In  the  malaria  vector  mosquito Anophelescoluzzii,  the  peptidoglycan receptor  PGRPLC  activates  the  Imd  pathway  limiting  both  the  microbiota  load  and Plasmodiuminfection. Here, we carried out an RNAi screen to examine the role of all seven Anopheles PGRPs in infections  with Plasmodium  berghei  and Plasmodium  falciparum.  We  show  that,  in  addition  to PGRPLC,  PGRPLA  and  PGRPS2/S3  also  participate  in  antiparasitic  defenses,  and  that  PGRPLB promotes mosquito permissiveness to P. falciparum. We also demonstrate that following a mosquito blood feeding, which promotes growth of the gut microbiota, PGRPLA and PGRPLB positively and negatively regulate the activation of the Imd pathway, respectively. Our data demonstrate that PGRPs are important regulators of the mosquito epithelial immunity and vector competence.
AU  - Gendrin,MEM
AU  - Turlure,F
AU  - Rodgers,FH
AU  - Cohuet,A
AU  - Morlais,I
AU  - Christophides,GK
DO  - 10.1159/000452797
EP  - 342
PY  - 2017///
SN  - 1662-8128
SP  - 333
TI  - The peptidoglycan recognition proteins PGRPLA and PGRPLB regulate Anopheles immunity to bacteria and affect infection by Plasmodium
T2  - Journal of Innate Immunity
UR  - http://dx.doi.org/10.1159/000452797
UR  - http://hdl.handle.net/10044/1/42573
VL  - 9
ER  -
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