Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Lecturer







Guy Scadding BuildingRoyal Brompton Campus





Graham Clarke is an accomplished clinical research physiologist. He completed his PhD under Dr Brian O'Connor at King's College in 2006 where he developed a novel non-invasive method of measuring bronchial blood flow.

In 2006 Dr Clarke was awarded an ERS Young Scientist Award for his work on the role of VEGF on the airway vasculature during allergic inflammation. In the same year he joined Professor Mitchell's group at Imperial College.

His research interests are to understand nitric oxide and angiogenic regulatory effects on airway and vascular smooth muscle function in patients with asthma, COPD and idiopathic pulmonary hypertension. Dr Clarke collaborates with industry on biomarker and protocol development with particular focus on sputum, bronchial biopsy processing and nasal and airway challenge. He is considered an expert on inhaled allergen challenge and its effects on airway and airway vascular pathophysiology.

He is currently respiratory physiology section group leader at Guy's Drug Research Unit, London.