Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Lecturer







Guy Scadding BuildingRoyal Brompton Campus





Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)

Ekaterina Khaleva,  Anna Rattu, Chris Brightling, Andrew Bush, Apostolos Bossios, Arnaud Bourdin, Kian Fan Chung, Graham W. Clarke et al. Eur Respir J . 2022 Oct 13;2200606. doi: 10.1183/13993003.00606-2022.

3TR - A Pan-European cross-disease research consortium aimed at improving personalized biological treatment of asthma and COPD.

Celeste Porsbjerg, Anke-Hilse Maitland, Guy Brusselle, Giorgio Walter Canonica , Alvar Agusti, Rosa Faner, Claus F Vogelmeier, Martijn Nawijn, Maarten van den Berge, Franca Rusconi, Charles Pilette, Valeria Ramiconi, Pippa Powell, Rekha Chaudhuri, Kian Fan Chung, Jadwiga Wedzicha, Sejla Saglani , Marc Van der Schee, Liam Heaney, Arnaud Bourdin, Graham Roberts, Ratko Djukanovic, Piotr Kuna, Macei Kupczyk, Heribert Staudinger, Graham W. Clarke, Sven Erik Dahlen Chris Brightling. Eur Respir J. 2021 Oct 21;58(4):2102168. doi: 10.1183/13993003.02168-2021


The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial.

Naimish Patel, Danen Cunoosamy, Malin Fagerås, Ziad Taib, Sara Asimus, Tove Hegelund-Myrbäck, Sofia Lundin, Katerina Pardali, Nisha Kurian, Eva Ersdal, Cecilia Kristensson, Katarina Korsback, Robert Palmér, Mary N Brown, Steven Greenaway, Leonard Siew, Graham W Clarke, Stephen I Rennard, Barry J Make, Robert A Wise, Paul Jansson.. Int J Chron Obstruct Pulmon Dis. 2018 Mar 27;13:1009-1019.


Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs.

Lexmond AJ, Singh D, Frijlink HW, Clarke GW, Page CP, Forbes B, van den Berge M. Pulm Pharmacol Ther. 2018 Jan 10. pii: S1094-5539(17)30311-5. doi: 10.1016/j.pupt.2018.01.004. [Epub ahead of print] Review.


The effects of house dust mite sublingual immunotherapy tablet on immunologic biomarkers and nasal allergen challenge symptoms

Gunawardana NC, Zhao Q, Carayannopoulos LN, Tsai K, Malkov VA, Selverian D, Clarke G, Mant T, Butts BD, Lund K, Hansel TT, Nolte H. J Allergy Clin Immunol. 2018 Feb;141(2):785-788.e9. doi: 10.1016/j.jaci.2017.08.016. Epub 2017 Sep 11. No abstract available.


A Randomized Clinical Trial of Passive Immunotherapy with Single-Dose anti-Fel d 1 Monoclonal Antibodies REGN1908-1909 in Cat-induced Rhinoconjunctivitis: Exploratory Efficacy Endpoints, Safety, and Pharmacokinetics.

Stephen Durham, Christian Schwabe, Richard Robson, Cecilia Ahlström Emanuelsson, Mohamad Shamji, Dave Singh, Tim Mant, Graham Clarke, Sharon Zhong, Mohamed Kamal, Dore Newell, Neil Stahl, George D. Yancopoulos, Ana Kostic, Allen Radin. EAACI 2017


AZD7624, an inhaled p38 inhibitor for COPD, attenuates lung and systemic inflammation after LPS Challenge in humans.

Patel N, Cunoosamy D, Hegelund-Myrback, T, Pehrson R, Taib Z, Jansson P, Lundin S, Greenaway S, Clarke GW, Siew L.  ERS 2015


Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects.

 Singh D, Siew L, Christensen J, Plumb J, Clarke GW, Greenaway S, Perros-Huguet C, Clarke N, Kilty I, Tan L.. Eur J Clin Pharmacol. Eur J Clin Pharmacol . 2015 Oct;71(10):1175-84. doi: 10.1007/s00228-015-1920-1. Epub 2015 Aug 13.


Discordant intra-individual upper and lower airway responses following simultaneous nasal and bronchial allergen challenge:

Clarke GW Carayannopoulos L, Chung C, McCarthy J, Mordin C, Gill M, Haider F, , Siew L.. ERS 2014


Disease models of chronic inflammatory airway disease: applications & requirements for clinical trials. Diamant Z, Clarke GW, Piertse H, Gispert J. Curr Opin Pulm Med. 2014 Jan;20(1):37-45.

Launching the BIOSPIT Initiative: Harmonizing Sputum Outcomes in Multicenter Trials.

Clarke GW, Diamant Z, Greenaway S, Rainer M, Allen E, Gispert J. Pulm Pharmacol Ther. 2013 Jun;26(3):400-1. doi: 10.1016/j.pupt.2012.12.007. Epub 2013 Jan 2.


Non-Invasive Markers Of Oxidative Stress: Their Feasibility, Reproducibility And Relationship With Clinical Features In COPD. AJRCCM. 187:2013:A4107.

Clarke GW, Diamant Z, Allen E, Stenning J, Jurcevic J, Rainer M, Greenaway SD.


New and existing pharmacotherapeutic options for persistent asthma and COPD.

Diamant Z, Tarasevych S, Clarke GW Neth J Med. 2011 Nov-Dec;69(11):486-99. Review.


Induction of angiogenesis by airway smooth muscle from patients with asthma.

Simcock DE, Kanabar V, Clarke GW, Mahn K, Karner C, O'Connor BJ, Lee TH, Hirst SJ.. Am J Respir Crit Care Med. 2008 Sep 1;178(5):460-8.


Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects.

Brown RA, Clarke GW, Ledbetter CL, Hurle MJ, Denyer JC, Simcock DE, Coote JE, Savage TJ, Murdoch RD, Page CP, Spina D, O'Connor BJ. Eur Respir J. 2008 Feb;31(2):311-9.


Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease.

Mitchell JA, Paul-Clark MJ, Clarke GW, McMaster SK, Cartwright N. J Endocrinol. 2007 Jun;193(3):323-30. Review.