Imperial College London
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DrGrahamCole

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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g.cole

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

126 results found

Jones S, Shun-Shin MJ, Cole GD, Whinnett ZI, Francis DPet al., 2014, Iterative method for atrioventricular optimization of cardiac resynchronization therapy: is beauty only in the eye of the beholder? Reply, EUROPACE, Vol: 16, Pages: 1866-1866, ISSN: 1099-5129

Journal article

Dhutia NM, Cole GD, Zolgharni M, Manisty CH, Willson K, Parker KH, Hughes AD, Francis DPet al., 2014, Automated speckle tracking algorithm to aid on-axis imaging in echocardiography, Journal of Medical Imaging, Vol: 1, ISSN: 2329-4310

Obtaining a "correct" view in echocardiography is a subjective process in which an operator attempts to obtain images conforming to consensus standard views. Real-time objective quantification of image alignment may assist less experienced operators, but no reliable index yet exists. We present a fully automated algorithm for detecting incorrect medial/lateral translation of an ultrasound probe by image analysis. The ability of the algorithm to distinguish optimal from sub-optimal four-chamber images was compared to that of specialists-the current "gold-standard." The orientation assessments produced by the automated algorithm correlated well with consensus visual assessments of the specialists ([Formula: see text]) and compared favourably with the correlation between individual specialists and the consensus, [Formula: see text]. Each individual specialist's assessments were within the consensus of other specialists, [Formula: see text] of the time, and the algorithm's assessments were within the consensus of specialists 85% of the time. The mean discrepancy in probe translation values between individual specialists and their consensus was [Formula: see text], and between the automated algorithm and specialists' consensus was [Formula: see text]. This technology could be incorporated into hardware to provide real-time guidance for image optimisation-a potentially valuable tool both for training and quality control.

Journal article

Cole GD, Patel SJ, Zaman N, Barron AJ, Raphael CE, Mayet J, Francis DPet al., 2014, "Triple Therapy" of Heart Failure With Angiotensin-Converting Enzyme Inhibitor, Beta-Blocker, and Aldosterone Antagonist May Triple Survival Time Shouldn't We Tell Patients?, JACC-HEART FAILURE, Vol: 2, Pages: 545-548, ISSN: 2213-1779

Journal article

Cole GD, Francis DP, 2014, The challenge of delivering reliable science and guidelines: opportunities for all to participate, EUROPEAN HEART JOURNAL, Vol: 35, Pages: 2435-+, ISSN: 0195-668X

Journal article

Tofield A, 2014, Why is Obamacare so controversial?, Eur Heart J, Vol: 35, Pages: 2433-2434

Journal article

Jabbour R, Ling HZ, Norrington K, Amaral N, Zaman N, Aggarwal S, Aung N, Barron A, Manisty C, Baruah R, Cole GD, Missouris CG, Mayet J, Francis DP, Cheng AS, Thomas M, Woldman S, Okonko DOet al., 2014, Serum albumin changes and multivariate dynamic risk modelling in chronic heart failure, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 176, Pages: 437-443, ISSN: 0167-5273

Journal article

Rosen MR, Myerburg RJ, Francis DP, Cole GD, Marban Eet al., 2014, Translating Stem Cell Research to Cardiac Disease Therapies Pitfalls and Prospects for Improvement, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 64, Pages: 922-937, ISSN: 0735-1097

Journal article

Cole GD, Francis DP, 2014, Perioperative β blockade: guidelines do not reflect the problems with the evidence from the DECREASE trials, BMJ-BRITISH MEDICAL JOURNAL, Vol: 349, ISSN: 1756-1833

Journal article

Dhutia NM, Zolgharni M, Willson K, Cole G, Nowbar AN, Dawson D, Zielke S, Whelan C, Newton J, Mayet J, Manisty CH, Francis DPet al., 2014, Guidance for accurate and consistent tissue Doppler velocity measurement: comparison of echocardiographic methods using a simple vendor-independent method for local validation, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 15, Pages: 817-827, ISSN: 2047-2404

Journal article

Sau A, Cole G, Cook C, Shun-Shin M, Francis Det al., 2014, SYSTEMATIC ANALYSIS OF EUROPEAN SOCIETY OF CARDIOLOGY GUIDELINES: WHAT DO WE ACTUALLY BASE OUR PRACTICE ON?, HEART, Vol: 100, Pages: A63-A64, ISSN: 1355-6037

Journal article

Cook C, Cole G, Asaris P, Jabbour R, Francis Det al., 2014, THE ANNUAL GLOBAL ECONOMIC BURDEN OF HEART FAILURE, HEART, Vol: 100, Pages: A28-A29, ISSN: 1355-6037

Journal article

Zolgharni M, Dhutia NM, Cole GD, Bahmanyar MR, Jones S, Sohaib SMA, Tai SB, Willson K, Finegold JA, Francis DPet al., 2014, Automated Aortic Doppler Flow Tracing for Reproducible Research and Clinical Measurements, IEEE TRANSACTIONS ON MEDICAL IMAGING, Vol: 33, Pages: 1071-1082, ISSN: 0278-0062

Journal article

Cook CM, Cole G, Asaria P, Jabbour R, Francis Det al., 2014, The annual global economic burden of heart failure, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 16, Pages: 184-184, ISSN: 1388-9842

Journal article

Nowbar AN, Mielewczik M, Karavassilis M, Dehbi H-M, Shun-Shin MJ, Jones S, Howard JP, Cole GD, Francis DPet al., 2014, Discrepancies in autologous bone marrow stem cell trials and enhancement of ejection fraction (DAMASCENE): weighted regression and meta-analysis, British Medical Journal, Vol: 348, Pages: 1-9, ISSN: 1468-5833

Objective To investigate whether discrepancies in trials of use of bone marrow stem cells in patients with heart disease account for the variation in reported effect size in improvement of left ventricular function.Design Identification and counting of factual discrepancies in trial reports, and sample size weighted regression against therapeutic effect size. Meta-analysis of trials that provided sufficient information.Data sources PubMed and Embase from inception to April 2013.Eligibility for selecting studies Randomised controlled trials evaluating the effect of autologous bone marrow stem cells for heart disease on mean left ventricular ejection fraction.Results There were over 600 discrepancies in 133 reports from 49 trials. There was a significant association between the number of discrepancies and the reported increment in EF with bone marrow stem cell therapy (Spearman’s r=0.4, P=0.005). Trials with no discrepancies were a small minority (five trials) and showed a mean EF effect size of −0.4%. The 24 trials with 1-10 discrepancies showed a mean effect size of 2.1%. The 12 with 11-20 discrepancies showed a mean effect of size 3.0%. The three with 21-30 discrepancies showed a mean effect size of 5.7%. The high discrepancy group, comprising five trials with over 30 discrepancies each, showed a mean effect size of 7.7%.Conclusions Avoiding discrepancies is difficult but is important because discrepancy count is related to effect size. The mechanism is unknown but should be explored in the design of future trials because in the five trials without discrepancies the effect of bone marrow stem cell therapy on ejection fraction is zero.

Journal article

Jones S, Shun-Shin MJ, Cole GD, Sau A, March K, Williams S, Kyriacou A, Hughes AD, Mayet J, Frenneaux M, Manisty CH, Whinnett ZI, Francis DPet al., 2014, Applicability of the iterative technique for cardiac resynchronization therapy optimization: full-disclosure, 50-sequential-patient dataset of transmitral Doppler traces, with implications for future research design and guidelines, EUROPACE, Vol: 16, Pages: 541-550, ISSN: 1099-5129

Journal article

Nowbar AN, Cole GD, Shun-Shin MJ, Finegold JA, Francis DPet al., 2014, International RCT-based guidelines for use of preoperative stress testing and perioperative beta-blockers and statins in non-cardiac surgery, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 172, Pages: 138-143, ISSN: 0167-5273

Journal article

Howard JP, Cole GD, Sievert H, Bhatt DL, Papademetriou V, Kandzari DE, Davies JE, Francis DPet al., 2014, Unintentional overestimation of an expected antihypertensive effect in drug and device trials: Mechanisms and solutions, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 172, Pages: 29-35, ISSN: 0167-5273

Journal article

Bouri S, Shun-Shin MJ, Cole GD, Mayet J, Francis DPet al., 2014, Meta-analysis of secure randomised controlled trials of beta-blockade to prevent perioperative death in non-cardiac surgery, Heart, Vol: 100, Pages: 456-464, ISSN: 1355-6037

Background Current European and American guidelines recommend the perioperative initiation of a course of β-blockers in those at risk of cardiac events undergoing high- or intermediate-risk surgery or vascular surgery. The Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography (DECREASE) family of trials, the bedrock of evidence for this, are no longer secure. We therefore conducted a meta-analysis of randomised controlled trials of β-blockade on perioperative mortality, non-fatal myocardial infarction, stroke and hypotension in non-cardiac surgery using the secure data.Methods The randomised controlled trials of initiation of β-blockers before non-cardiac surgery were examined. Primary outcome was all-cause mortality at 30 days or at discharge. The DECREASE trials were separately analysed.Results Nine secure trials totalling 10 529 patients, 291 of whom died, met the criteria. Initiation of a course of β-blockers before surgery caused a 27% risk increase in 30-day all-cause mortality (p=0.04). The DECREASE family of studies substantially contradict the meta-analysis of the secure trials on the effect of mortality (p=0.05 for divergence). In the secure trials, β-blockade reduced non-fatal myocardial infarction (RR 0.73, p=0.001) but increased stroke (RR 1.73, p=0.05) and hypotension (RR 1.51, p<0.00001). These results were dominated by one large trial.Conclusions Guideline bodies should retract their recommendations based on fictitious data without further delay. This should not be blocked by dispute over allocation of blame. The well-conducted trials indicate a statistically significant 27% increase in mortality from the initiation of perioperative β-blockade that guidelines currently recommend. Any remaining enthusiasts might best channel their energy into a further randomised trial which should be designed carefully and conducted honestly.

Journal article

Cook C, Cole G, Asaria P, Jabbour R, Francis DPet al., 2014, The annual global economic burden of heart failure, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 171, Pages: 368-376, ISSN: 0167-5273

Journal article

Bouri S, Whinnett ZI, Cole GD, Manisty CH, Cleland JG, Francis DPet al., 2014, Definitions of Outcome, Response and Effect in Imaging Research to Avoid Confusion, JACC-CARDIOVASCULAR IMAGING, Vol: 7, Pages: 104-106, ISSN: 1936-878X

Journal article

Cole GD, Francis DP, 2014, Research failure can result in lost lives (Retracted article. See vol. 14, 2014), EUROPEAN HEART JOURNAL, Vol: 35, Pages: 135-137, ISSN: 0195-668X

Journal article

Zolgharni M, Dhutia NM, Cole GD, Willson K, Francis DPet al., 2014, Feasibility of using a reliable automated Doppler flow velocity measurements for research and clinical practices, Pages: 90401D-90401D

Conference paper

Dhutia NM, Zolgharni M, Willson K, Cole G, Nowbar AN, Manisty CH, Francis DPet al., 2014, Calibration of echocardiographic tissue doppler velocity, using simple, universally-applicable methods, Pages: 90400G-90400G

Conference paper

Barron AJ, Zaman N, Cole GD, Wensel R, Okonko DO, Francis DPet al., 2013, Systematic review of genuine versus spurious side-effects of beta-blockers in heart failure using placebo control: Recommendations for patient information, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 3572-3579, ISSN: 0167-5273

Journal article

Nowbar AN, Cole GD, Francis DP, 2013, The changing relative contribution of operator salary and hardware costs to echocardiography - A historical perspective, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 1641-1641, ISSN: 0167-5273

Journal article

Raphael CE, Kyriacou A, Jones S, Pabari P, Cole G, Baruah R, Hughes AD, Francis DPet al., 2013, Multinational evaluation of the interpretability of the iterative method of optimisation of AV delay for CRT, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 407-413, ISSN: 0167-5273

Journal article

Mielewczik M, Cole GD, Nowbar AN, Schilling R, Whinnett ZI, Bordachar P, Wilmshurst P, Chambers JC, Olshansky B, Morgan J, otherset al., 2013, The C-CURE Randomized Clinical Trial (Cardiopoietic stem Cell therapy in heart failURE), Journal of the American College of Cardiology, Vol: 62, Pages: 2453-2453

Journal article

Francis DP, Mielewczik M, Zargaran D, Cole GDet al., 2013, Autologous bone marrow-derived stem cell therapy in heart disease: discrepancies and contradictions, International journal of cardiology, Vol: 168, Pages: 3381-3403

Journal article

Zaman N, Barron AJ, Cole GD, Wensel R, Okonko DO, Francis DPet al., 2012, Systematic review of the proportion of heart failure patients reporting side effects of beta-blockers in whom the medication is genuinely causative: ethical implications for informed consent, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 804-804, ISSN: 0195-668X

Conference paper

Jabbour RJ, Husain S, Zaman N, Aung N, Ling HZ, Baruah R, Cole G, Manisty C, Barron A, Mayet J, Francis D, Thomas M, Woldman S, Okonko DOet al., 2012, MULTICENTRE VALIDATION OF THE ADVERSE PROGNOSTIC IMPLICATIONS OF DECLINING SERUM ALBUMIN LEVELS IN CHRONIC HEART FAILURE, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A9-A9, ISSN: 1355-6037

Conference paper

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