Imperial College London
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DrGrahamCole

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

g.cole

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Patel:2019:10.1016/j.psychres.2019.112491,
author = {Patel, RK and Moore, AM and Piper, S and Sweeney, M and Whiskey, E and Cole, G and Shergill, SS and Plymen, CM},
doi = {10.1016/j.psychres.2019.112491},
journal = {Psychiatry Research},
pages = {1--8},
title = {Clozapine and cardiotoxicity - A guide for psychiatrists written by cardiologists},
url = {http://dx.doi.org/10.1016/j.psychres.2019.112491},
volume = {282},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This review discusses the rare but potentially life-threatening cardiovascular side-effects of myocarditis and dilated cardiomyopathy associated with the use of Clozapine. The clinical presentation of these conditions is non-specific, making it difficult to both risk-stratify and identify patients who develop these consequences. This review aims to examine the proposed aetiologies, diagnostic approaches and subsequent management strategies of cardiotoxicity associated with clozapine use; offering guidance to psychiatrists and general physicians. Current evidence highlights the importance of accurate diagnosis to prevent premature and unnecessary cessation of clozapine. Guidance on monitoring and reintroduction of the drug is emerging and current practice recommends a combination of regular monitoring of biomarkers and imaging to make a diagnosis of cardiotoxicity although further work is needed to establish evidence-based guidelines.
AU  - Patel,RK
AU  - Moore,AM
AU  - Piper,S
AU  - Sweeney,M
AU  - Whiskey,E
AU  - Cole,G
AU  - Shergill,SS
AU  - Plymen,CM
DO  - 10.1016/j.psychres.2019.112491
EP  - 8
PY  - 2019///
SN  - 0165-1781
SP  - 1
TI  - Clozapine and cardiotoxicity - A guide for psychiatrists written by cardiologists
T2  - Psychiatry Research
UR  - http://dx.doi.org/10.1016/j.psychres.2019.112491
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000503096100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0165178119313861?via%3Dihub
VL  - 282
ER  -
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