Publications
414 results found
Vera J, Walker AE, Kinderlerer A, et al., 2012, Transient bone marrow oedema syndrome in an HIV-infectedpatient on highly active antiretroviral therapy, International Journal of STD & AIDS
Ashby J, Braithewaite B, Walsh J, et al., 2012, HIV testing uptake and acceptability in an inner city polyclinic, AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, Vol: 24, Pages: 905-909, ISSN: 0954-0121
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- Citations: 8
Howitt P, Darzi A, Yang GZ, et al., 2012, Technologies for global health, The Lancet, Vol: 380, Pages: 507-535
Ford N, Kirby C, Singh K, et al., 2012, Chronic hepatitis C treatment outcomes in low and middle-income countries: a systematic review and meta-analysis, Bulletin World Health Organisation, Pages: 540-550
Lessells RJ, Cooke GS, Newell ML, et al., 2011, Evaluation of Tuberculosis Diagnostics: Establishing an Evidence Base Around the Public Health Impact, Journal of Infectious Diseases, Vol: 204 (suppl 4), Pages: 1187-1195
Cooke GS, Beaton RK, Lessells RJ, et al., 2011, International Spread of MDR TB from Tugela Ferry, South Africa, EMERGING INFECTIOUS DISEASES, Vol: 17, Pages: 2035-2037, ISSN: 1080-6040
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- Citations: 20
Batz H-G, Cooke GS, Reid SD, 2011, Towards Lab Free Tuberculosis Diagnosis
Connell DW, Berry M, Cooke G, et al., 2011, Update on tuberculosis: TB in the early 21st century., Eur Respir Rev, Vol: 20, Pages: 71-84, ISSN: 1600-0617
Cooke GS, Levin M, Wilkinson RJ, et al., 2011, Host Genetics and Susceptibility to Infection, Tropical Infectious Diseases: Principles, Pathogens and Practice, Pages: 32-39, ISBN: 9781437737776
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- Citations: 1
Lessells RJ, Mutevedzi PC, Cooke GS, et al., 2011, Retention in HIV Care for Individuals Not Yet Eligible for Antiretroviral Therapy: Rural KwaZulu-Natal, South Africa, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 56, Pages: E79-E86, ISSN: 1525-4135
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- Citations: 104
Cooke GS, Levin M, Wilkinson RJ, et al., 2011, Host Genetics and Susceptibility to Infection, Tropcial Infectious Diseases: Principles, Pathogens and Practice, Editors: Guerrant, Walker, Weller, Publisher: Elsevier
Sturdy A, Goodman A, Jose R, et al., 2011, Multi-drug resistant tuberculosis (MDR-TB) treatment in the UK: a study of injectable use and toxicity in practice, Journal of Antimicrobial Chemotherapy, Pages: 1815-1820
Huang K-HG, Bonsall D, Katzourakis A, et al., 2010, B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection, Nature Communications, Vol: 7
HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investigate the role of B cells in an HIV-infected patient. The HIV-1+ patient studied here was not taking antiretroviral drugs and was treated for pre-existing low-grade lymphoplasmacytoid lymphoma by depletion of CD20+ B cells using rituximab. We demonstrate that B-cell depletion results in a decline in autologous neutralizing antibody (NAb) responses and a 1.7 log10 rise in HIV-1 plasma viral load (pVL). The recovery of NAbs results in a decline in pVL. The HIV-1 sequences diversify and NAb-resistant mutants are subsequently selected. These data suggest that B-cell function can contribute to the long-term control of pVL, and that NAbs may be more important in controlling chronic HIV-1 infection than previously suspected.
Huang KH, Bonsall D, Katzourakis A, et al., 2010, B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection., Nat Commun, Vol: 1, ISSN: 2041-1723
HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investigate the role of B cells in an HIV-infected patient. The HIV-1(+) patient studied here was not taking antiretroviral drugs and was treated for pre-existing low-grade lymphoplasmacytoid lymphoma by depletion of CD20+ B cells using rituximab. We demonstrate that B-cell depletion results in a decline in autologous neutralizing antibody (NAb) responses and a 1.7 log(10) rise in HIV-1 plasma viral load (pVL). The recovery of NAbs results in a decline in pVL. The HIV-1 sequences diversify and NAb-resistant mutants are subsequently selected. These data suggest that B-cell function can contribute to the long-term control of pVL, and that NAbs may be more important in controlling chronic HIV-1 infection than previously suspected.
Cooke GS, Tanser FC, Barnighausen T, et al., 2010, Population uptake of antiretroviral treatment through primary care in rural South Africa., BMC Public Health (2010), Pages: 585-595
Mutevedzi PC, Lessells RJ, Heller T, et al., 2010, Scale-up of a decentralized HIV treatment programme in rural KwaZulu-Natal, South Africa: does rapid expansion affect patient outcomes?, BULLETIN OF THE WORLD HEALTH ORGANIZATION, Vol: 88, Pages: 593-600, ISSN: 0042-9686
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- Citations: 98
Croucher A, Vera J, Akolo C, et al., 2010, Acute renal failure due to immune reconstitution inflammatory interstitial nephritis in an HIV-positive patient, AIDS, Vol: 24, Pages: 1788-1790
Elkington PT, Cooke GS, 2010, MMP12, Lung Function, and COPD in High-Risk Populations., NEW ENGLAND JOURNAL OF MEDICINE, Vol: 362, Pages: 1241-1241, ISSN: 0028-4793
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- Citations: 4
Heller T, Lessells RJ, Wallrauch CG, et al., 2010, Community-based treatment for multidrug-resistant tuberculosis in rural KwaZulu-Natal, South Africa, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 14, Pages: 420-426, ISSN: 1027-3719
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- Citations: 52
Cooke GS, Main J, Thursz MR, 2010, Treatment for hepatitis B, BMJ-BRITISH MEDICAL JOURNAL, Vol: 340, ISSN: 1756-1833
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- Citations: 15
Thursz M, Cooke GS, Hall AJ, 2010, Hepatitis B treatment in resource poor settings: time for action, TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 15, Pages: 2-4, ISSN: 1360-2276
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- Citations: 12
Lightowler JVJ, Cooke GS, Mutevedzi P, et al., 2010, Treatment of Cryptococcal Meningitis in KwaZulu-Natal, South Africa, PLoS One, Vol: 5
Houlihan CF, Mutevedzi P, Lessells RJ, et al., 2010, The tuberculosis challenge in a rural South African HIV programme, BMC Infectious Diseases, Vol: 10;23
Herbst AJ, Cooke GS, Barnighausen T, et al., 2009, Adult mortality and antiretroviral treatment roll-out in rural KwaZulu-Natal, South Africa, BULLETIN OF THE WORLD HEALTH ORGANIZATION, Vol: 87, Pages: 754-762, ISSN: 0042-9686
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- Citations: 128
Cooke GS, Little KE, Bland RM, et al., 2009, Need for Timely Paediatric HIV Treatment within Primary Health Care in Rural South Africa, PLOS ONE, Vol: 4, ISSN: 1932-6203
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- Citations: 11
Franey C, Knott D, Barnighausen T, et al., 2009, Renal impairment in a rural African antiretroviral programme, BMC Infectious Diseases, Vol: 9
Tanser F, Barnighausen T, Cooke GS, et al., 2009, Localized spatial clustering of HIV infections in a widely disseminated rural South African epidemic, International Journal of Epidemiology
Cooke GS, Little K, Thulare H, et al., 2009, Need for HIV treatment in rural South Africa, PLoS One (in press)
Wall E, Cooke GS, 2009, Jaundice in the returning traveller, Medicine, Publisher: Elsevier
O'Riordan P, Schwab U, Logan S, et al., 2008, Rapid Molecular Detection of Rifampicin Resistance Facilitates Early Diagnosis and Treatment of Multi-Drug Resistant Tuberculosis: Case Control Study, PLOS ONE, Vol: 3, ISSN: 1932-6203
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- Citations: 35
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