Imperial College London
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ProfessorGrahamCooke

Faculty of Medicine, Department of Infectious Disease

Vice Dean (Research); Professor of Infectious Diseases
 
 
 
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Contact

 

g.cooke

 
 
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Location

 

Infectious Diseases SectionMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ward:2022:10.1038/s41467-022-28527-x,
author = {Ward, H and Whittaker, M and Flower, B and Tang, S and Atchison, C and Darzi, A and Donnelly, C and Cann, A and Diggle, P and Ashby, D and Riley, S and Barclay, W and Elliott, P and Cooke, G},
doi = {10.1038/s41467-022-28527-x},
journal = {Nature Communications},
title = {Population antibody responses following COVID-19 vaccination in 212,102 individuals},
url = {http://dx.doi.org/10.1038/s41467-022-28527-x},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Population antibody surveillance helps track immune responses to COVID-19 vaccinations at scale, and identify host factors that may affect antibody production. We analyse data from 212,102 vaccinated individuals within the REACT-2 programme in England, which uses self-administered lateral flow antibody tests in sequential cross-sectional community samples; 71,923 (33.9%) received at least one dose of BNT162b2 vaccine and 139,067 (65.6%) received ChAdOx1. For both vaccines, antibody positivity peaks 4-5 weeks after first dose and then declines. At least 21 days after second dose of BNT162b2, close to 100% of respondents test positive, while for ChAdOx1, this is significantly reduced, particularly in the oldest age groups (72.7% [70.9–74.4] at ages 75 years and above). For both vaccines, antibody positivity decreases with age, and is higher in females and those with previous infection. Antibody positivity is lower in transplant recipients, obese individuals, smokers and those with specific comorbidities. These groups will benefit from additional vaccine doses.
AU  - Ward,H
AU  - Whittaker,M
AU  - Flower,B
AU  - Tang,S
AU  - Atchison,C
AU  - Darzi,A
AU  - Donnelly,C
AU  - Cann,A
AU  - Diggle,P
AU  - Ashby,D
AU  - Riley,S
AU  - Barclay,W
AU  - Elliott,P
AU  - Cooke,G
DO  - 10.1038/s41467-022-28527-x
PY  - 2022///
SN  - 2041-1723
TI  - Population antibody responses following COVID-19 vaccination in 212,102 individuals
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-28527-x
UR  - http://hdl.handle.net/10044/1/94563
VL  - 13
ER  -
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