Imperial College London
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ProfessorGrahamCooke

Faculty of Medicine, Department of Infectious Disease

Vice Dean (Research); Professor of Infectious Diseases
 
 
 
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Contact

 

g.cooke

 
 
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Location

 

Infectious Diseases SectionMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Whitaker:2022:10.1038/s41467-022-29521-z,
author = {Whitaker, M and Elliott, J and Chadeau, M and Riley, S and Darzi, A and Cooke, G and Ward, H and Elliott, P},
doi = {10.1038/s41467-022-29521-z},
journal = {Nature Communications},
title = {Persistent COVID-19 symptoms in a community study of 606,434 people in England},
url = {http://dx.doi.org/10.1038/s41467-022-29521-z},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Long COVID remains a broadly defined syndrome, with estimates of prevalence and duration varying widely. We use data from rounds 3–5 of the REACT-2 study (n=508,707; September 2020 – February 2021), a representative community survey of adults in England,  and replication data from round 6 (n=97,717; May 2021) to estimate the prevalence and identify predictors of persistent symptoms lasting 12 weeks or more; and unsupervised learning to cluster individuals by reported symptoms. At 12 weeks in rounds 3–5, 37.7% experienced at least one symptom, falling to 21.6% in round 6. Female sex, increasing age, obesity, smoking, vaping, hospitalisation with COVID-19, deprivation, and being a healthcare worker are associated with higher probability of persistent symptoms in rounds 3–5, and Asian ethnicity with lower probability. Clustering analysis identifies a subset of participants with predominantly respiratory symptoms. Managing the long-term sequelae of COVID-19 will remain a major challenge for affected individuals and their families and for health services.
AU  - Whitaker,M
AU  - Elliott,J
AU  - Chadeau,M
AU  - Riley,S
AU  - Darzi,A
AU  - Cooke,G
AU  - Ward,H
AU  - Elliott,P
DO  - 10.1038/s41467-022-29521-z
PY  - 2022///
SN  - 2041-1723
TI  - Persistent COVID-19 symptoms in a community study of 606,434 people in England
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-29521-z
UR  - http://hdl.handle.net/10044/1/95785
VL  - 13
ER  -
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