Imperial College London
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ProfessorGrahamCooke

Faculty of Medicine, Department of Infectious Disease

Vice Dean (Research); Professor of Infectious Diseases
 
 
 
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g.cooke

 
 
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Location

 

Infectious Diseases SectionMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Flower:2022:10.1016/j.lanwpc.2022.100468,
author = {Flower, B and Du, Hong D and Vu, Thi Kim H and Pham, Minh K and Geskus, RB and Day, J and Cooke, GS},
doi = {10.1016/j.lanwpc.2022.100468},
journal = {The Lancet Regional Health - Western Pacific},
pages = {1--20},
title = {Seroprevalence of Hepatitis B, C and D in Vietnam: A systematic review and meta-analysis.},
url = {http://dx.doi.org/10.1016/j.lanwpc.2022.100468},
volume = {24},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Vietnam has one of the greatest disease burdens from chronic viral hepatitis. Comprehensive prevalence data are essential to support its elimination as a public health threat. Methods: We searched Medline and Embase from 1990 to 2021 for seroprevalence data relating to Hepatitis B (HBV), C (HCV) and D (HDV) in Vietnam. We estimated pooled prevalence with a DerSimonian-Laird random-effects model and stratified study populations into i) low-risk ii) high-risk exposure and iii) liver disease. We further estimated prevalence by decade and region and rates of HIV-coinfection. Findings: We analysed 72 studies, including 120 HBV, 114 HCV and 23 HDV study populations. Pooled HBV prevalence was low in blood donors (1.86% [1.82-1.90]) but high in antenatal populations (10.8% [10.1-11.6]) and adults in the general population (10.5% [10.0-11.0]). It was similar or modestly increased in groups at highest risk of exposure, suggesting the epidemic is largely driven by chronic infections acquired in childhood. HCV pooled prevalence in the general population was lower than historical estimates: 0.26% (0.09-0.51) have active infection defined by detectable antigen or HCV RNA. In contrast, there is an extremely high prevalence of active HCV infection in people who inject drugs (PWID) (57.8% [56.5-59.1]), which has persisted through the decades despite harm-reduction interventions. HDV appears mainly confined to high-risk groups. Interpretation: Blood safety has improved, but renewed focus on HBV vaccination at birth and targeted HCV screening and treatment of PWID are urgently required to meet elimination targets. Large cross-sectional studies are needed to better characterize HDV prevalence, but mass screening may not be warranted. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
AU  - Flower,B
AU  - Du,Hong D
AU  - Vu,Thi Kim H
AU  - Pham,Minh K
AU  - Geskus,RB
AU  - Day,J
AU  - Cooke,GS
DO  - 10.1016/j.lanwpc.2022.100468
EP  - 20
PY  - 2022///
SN  - 2666-6065
SP  - 1
TI  - Seroprevalence of Hepatitis B, C and D in Vietnam: A systematic review and meta-analysis.
T2  - The Lancet Regional Health - Western Pacific
UR  - http://dx.doi.org/10.1016/j.lanwpc.2022.100468
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35573318
UR  - https://www.sciencedirect.com/science/article/pii/S2666606522000839?via%3Dihub
UR  - http://hdl.handle.net/10044/1/97168
VL  - 24
ER  -
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