Imperial College London
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ProfessorGrahamCooke

Faculty of Medicine, Department of Infectious Disease

Vice Dean (Research); Professor of Infectious Diseases
 
 
 
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g.cooke

 
 
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Location

 

Infectious Diseases SectionMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fink:2023:10.1016/S1473-3099(22)00806-4,
author = {Fink, DL and Callaby, H and Luintel, A and Beynon, W and Bond, H and Lim, EY and Gkrania-Klotsas, E and Heskin, J and Bracchi, M and Rathish, B and Milligan, I and O'Hara, G and Rimmer, S and Peters, JR and Payne, L and Mody, N and Hodgson, B and Lewthwaite, P and Lester, R and Woolley, SD and Sturdy, A and Whittington, A and Johnson, L and Jacobs, N and Quartey, J and Ai, Payne B and Crowe, S and Elliott, IA and Harrison, T and Cole, J and Beard, K and Cusack, T-P and Jones, I and Banerjee, R and Rampling, T and Specialist, and High Consequence Infectious Diseases Centres Network for Monkeypox and Dunning, J},
doi = {10.1016/S1473-3099(22)00806-4},
journal = {Lancet Infectious Diseases},
pages = {589--597},
title = {Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study.},
url = {http://dx.doi.org/10.1016/S1473-3099(22)00806-4},
volume = {23},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The scale of the 2022 global mpox (formerly known as monkeypox) outbreak has been unprecedented. In less than 6 months, non-endemic countries have reported more than 67 000 cases of a disease that had previously been rare outside of Africa. Mortality has been reported as rare but hospital admission has been relatively common. We aimed to describe the clinical and laboratory characteristics and outcomes of individuals admitted to hospital with mpox and associated complications, including tecovirimat recipients. METHODS: In this cohort study, we undertook retrospective review of electronic clinical records and pathology data for all individuals admitted between May 6, and Aug 3, 2022, to 16 hospitals from the Specialist and High Consequence Infectious Diseases Network for Monkeypox. The hospitals were located in ten cities in England and Northern Ireland. Inclusion criteria were clinical signs consistent with mpox and MPXV DNA detected from at least one clinical sample by PCR testing. Patients admitted solely for isolation purposes were excluded from the study. Key outcomes included admission indication, complications (including pain, secondary infection, and mortality) and use of antibiotic and anti-viral treatments. Routine biochemistry, haematology, microbiology, and virology data were also collected. Outcomes were assessed in all patients with available data. FINDINGS: 156 individuals were admitted to hospital with complicated mpox during the study period. 153 (98%) were male and three (2%) were female, with a median age of 35 years (IQR 30-44). Gender data were collected from electronic patient records, which encompassed full formal review of clincian notes. The prespecified options for data collection for gender were male, female, trans, non-binary, or unknown. 105 (71%) of 148 participants with available ethnicity data were of White ethnicity and 47 (30%) of 155 were living with HIV with a median CD4 count of 510 cells per mm3 (IQR 349-828).
AU  - Fink,DL
AU  - Callaby,H
AU  - Luintel,A
AU  - Beynon,W
AU  - Bond,H
AU  - Lim,EY
AU  - Gkrania-Klotsas,E
AU  - Heskin,J
AU  - Bracchi,M
AU  - Rathish,B
AU  - Milligan,I
AU  - O'Hara,G
AU  - Rimmer,S
AU  - Peters,JR
AU  - Payne,L
AU  - Mody,N
AU  - Hodgson,B
AU  - Lewthwaite,P
AU  - Lester,R
AU  - Woolley,SD
AU  - Sturdy,A
AU  - Whittington,A
AU  - Johnson,L
AU  - Jacobs,N
AU  - Quartey,J
AU  - Ai,Payne B
AU  - Crowe,S
AU  - Elliott,IA
AU  - Harrison,T
AU  - Cole,J
AU  - Beard,K
AU  - Cusack,T-P
AU  - Jones,I
AU  - Banerjee,R
AU  - Rampling,T
AU  - Specialist,and High Consequence Infectious Diseases Centres Network for Monkeypox
AU  - Dunning,J
DO  - 10.1016/S1473-3099(22)00806-4
EP  - 597
PY  - 2023///
SN  - 1473-3099
SP  - 589
TI  - Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study.
T2  - Lancet Infectious Diseases
UR  - http://dx.doi.org/10.1016/S1473-3099(22)00806-4
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36566771
UR  - https://www.sciencedirect.com/science/article/pii/S1473309922008064?via%3Dihub
UR  - http://hdl.handle.net/10044/1/101450
VL  - 23
ER  -
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