Imperial College London

DrGaborFoldes

Faculty of MedicineNational Heart & Lung Institute

Research Fellow
 
 
 
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Contact

 

g.foldes

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dolatshad:2015:10.3389/fcell.2015.00076,
author = {Dolatshad, NF and Hellen, N and Jabbour, R and Harding, SE and Foldes, G},
doi = {10.3389/fcell.2015.00076},
journal = {Frontiers in Cell and Developmental Biology},
title = {G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling},
url = {http://dx.doi.org/10.3389/fcell.2015.00076},
volume = {3},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths and limitations of this new model system. G-protein coupled receptors (GPCRs) are key regulators of stem cell maintenance and differentiation and have an important role in cardiovascular cell signalling. In this review, we will therefore describe the state of knowledge concerning the regulatory role of GPCRs in both the generation and function of pluripotent stem cell derived-cardiomyocytes, -endothelial and -vascular smooth muscle cells. We will consider how far the in vitro disease models recapitulate authentic GPCR signalling and provide a useful basis for discovery of disease mechanisms or design of therapeutic strategies.
AU - Dolatshad,NF
AU - Hellen,N
AU - Jabbour,R
AU - Harding,SE
AU - Foldes,G
DO - 10.3389/fcell.2015.00076
PY - 2015///
SN - 2296-634X
TI - G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling
T2 - Frontiers in Cell and Developmental Biology
UR - http://dx.doi.org/10.3389/fcell.2015.00076
UR - http://hdl.handle.net/10044/1/28393
VL - 3
ER -