Imperial College London

ProfessorGadFrankel

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Molecular Pathogenesis
 
 
 
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Contact

 

+44 (0)20 7594 5253g.frankel

 
 
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Location

 

1.46Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

244 results found

Garmendia J, Carlier M-F, Egile C, Didry D, Frankel Get al., 2006, Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection, CELLULAR MICROBIOLOGY, Vol: 8, Pages: 1444-1455, ISSN: 1462-5814

Journal article

Smollett K, Shaw RK, Garmendia J, Knutton S, Frankel Get al., 2006, Function and distribution of EspG2, a type III secretion system effector of enteropathogenic Escherichia coli., Microbes Infect, Vol: 8, Pages: 2220-2227, ISSN: 1286-4579

The enteropathogenic Escherichia coli (EPEC) effector protein EspG, like the Shigella effector VirA, functions through disruption of the host cell microtubule network. Reports have differed as to whether the EspG homologue, EspG2, is also responsible for microtubule disruption. In this study we show that following translocation, EspG2 and VirA are localised under adherent bacteria and able to restore the microtubule disruption phenotype to an espG/espG2 double EPEC mutant. The espG/espG2 double mutant produced A/E lesions similar to wild-type EPEC on human intestinal in vitro organ cultures. Determining the distribution of espG and espG2 among clinical EPEC isolates revealed two different types of espG (espG alpha and espG beta) and espG2 (intact and pseudo genes), which were associated with specific EPEC serotypes and closely followed the EPEC lineage. This investigation has established a role for EspG2 in the disruption of the microtubule network and associated different espG and espG2 types with different groups of EPEC.

Journal article

Whale AD, Garmendia J, Gomes TA, Frankel Get al., 2006, A novel category of enteropathogenic Escherichia coli simultaneously utilizes the Nck and TccP pathways to induce actin remodelling, CELLULAR MICROBIOLOGY, Vol: 8, Pages: 999-1008, ISSN: 1462-5814

Journal article

Fitzhenry R, Dahan S, Torres AG, Chong Y, Heuschkel R, Murch SH, Thomson M, Kaper JB, Frankel G, Phillips ADet al., 2006, Long polar fimbriae and tissue tropism in Escherichia coli O157 : H7, MICROBES AND INFECTION, Vol: 8, Pages: 1741-1749, ISSN: 1286-4579

Journal article

Marches O, Batchelor M, Shaw RK, Patel A, Cummings N, Nagai T, Sasakawa C, Carlsson SR, Lundmark R, Cougoule C, Caron E, Knutton S, Connerton I, Frankel Get al., 2006, EspF of enteropathogenic Escherichia coli binds sorting nexin 9, JOURNAL OF BACTERIOLOGY, Vol: 188, Pages: 3110-3115, ISSN: 0021-9193

Journal article

Kelly M, Hart E, Mundy R, Marches O, Wiles S, Badea L, Luck S, Tauschek M, Frankel G, Robins-Browne RM, Hartland ELet al., 2006, Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium, INFECTION AND IMMUNITY, Vol: 74, Pages: 2328-2337, ISSN: 0019-9567

Journal article

Wiles S, Hanage WP, Frankel G, Robertson Bet al., 2006, Modelling infectious disease - time to think outside the box?, NATURE REVIEWS MICROBIOLOGY, Vol: 4, Pages: 307-312, ISSN: 1740-1526

Journal article

Simpson N, Shaw R, Crepin VF, Mundy R, FitzGerald AJ, Cummings N, Straatman-Iwanowska A, Connerton I, Knutton S, Frankel Get al., 2006, The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea, MOLECULAR MICROBIOLOGY, Vol: 60, Pages: 349-363, ISSN: 0950-382X

Journal article

Caron E, Crepini VF, Simpson N, Knutton S, Garmendia J, Frankel Get al., 2006, Subversion of actin dynamics by EPEC and EHEC, CURRENT OPINION IN MICROBIOLOGY, Vol: 9, Pages: 40-45, ISSN: 1369-5274

Journal article

Malfitano AM, Cahill R, Mitchell P, Frankel G, Dougan G, Bifulco M, Lombardi G, Lechler RI, Bamford KBet al., 2006, Helicobacter pylori has stimulatory effects on naive T cells, HELICOBACTER, Vol: 11, Pages: 21-30, ISSN: 1083-4389

Journal article

Vlisidou I, Dziva F, La Ragione RM, Best A, Garmendia J, Hawes P, Monaghan P, Cawthraw SA, Frankel G, Woodward MJ, Stevens MPet al., 2006, Role of intimin-Tir interactions and the Tir-cytoskeleton coupling protein in the colonization of calves and lambs by Escherichia coli O157 : H7, INFECTION AND IMMUNITY, Vol: 74, Pages: 758-764, ISSN: 0019-9567

Journal article

Patel A, Cummings N, Batchelor M, Hill PJ, Dubois T, Mellits KH, Frankel G, Connerton Iet al., 2006, Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3 tau binds Tir and has a role in EPEC-induced actin polymerization, CELLULAR MICROBIOLOGY, Vol: 8, Pages: 55-71, ISSN: 1462-5814

Journal article

Tatsuno I, Mundy R, Frankel G, Chong YW, Phillips AD, Torres AG, Kaper JBet al., 2006, The lpf gene cluster for long polar fimbriae is not involved in adherence of enteropathogenic Escherichia coli or virulence of Citrobacter rodentium, INFECTION AND IMMUNITY, Vol: 74, Pages: 265-272, ISSN: 0019-9567

Journal article

Ramboarina S, Fernandes PJ, Daniell S, Islam S, Simpson P, Frankel G, Booy F, Donnenberg MS, Matthews Set al., 2005, Structure of the bundle-forming pilus from enteropathogenic Escherichia coli, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 40252-40260

Journal article

Marches O, Wiles S, Dziva F, La Ragione RM, Schuller S, Best A, Phillips AD, Hartland EL, Woodward MJ, Stevens MP, Frankel Get al., 2005, Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens, INFECTION AND IMMUNITY, Vol: 73, Pages: 8411-8417, ISSN: 0019-9567

Journal article

Mundy R, MacDonald TT, Dougan G, Frankel G, Wiles Set al., 2005, Citrobacter rodentium of mice and man, CELLULAR MICROBIOLOGY, Vol: 7, Pages: 1697-1706, ISSN: 1462-5814

Journal article

Garmendia J, Ren ZH, Tennant S, Aparecida M, Viera M, Chong YW, Whale A, Azzopardi K, Dahan S, Sircili MP, Franzolin MR, Trabulsi LR, Phillips A, Gomes TAT, Xu JG, Robins-Browne R, Frankel Get al., 2005, Distribution of tccP in clinical enterohemorrhagic and enteropathogenic Escherichia coli isolates, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 43, Pages: 5715-5720, ISSN: 0095-1137

Journal article

Girard F, Batisson I, Frankel GM, Harel J, Fairbrother JMet al., 2005, Interaction of enteropathogenic and Shiga toxin-producing Escherichia coli and porcine intestinal mucosa: Role of intimin and Tir in adherence, INFECTION AND IMMUNITY, Vol: 73, Pages: 6005-6016, ISSN: 0019-9567

Journal article

Wiles S, Dougan G, Frankel G, 2005, Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract, CELLULAR MICROBIOLOGY, Vol: 7, Pages: 1163-1172, ISSN: 1462-5814

Journal article

Shaw RK, Smollett K, Cleary J, Garmendia J, Straatman-Iwanowska A, Frankel G, Knutton Set al., 2005, Enteropathogenic Escherichia coli type III effectors EspG and EspG2 disrupt the microtubule network of intestinal epithelial cells, INFECTION AND IMMUNITY, Vol: 73, Pages: 4385-4390, ISSN: 0019-9567

Journal article

Crepin VF, Shaw R, Knutton S, Frankel Get al., 2005, Molecular basis of antigenic polymorphism of EspA filaments: Development of a peptide display technology, JOURNAL OF MOLECULAR BIOLOGY, Vol: 350, Pages: 42-52, ISSN: 0022-2836

Journal article

Garmendia J, Frankel G, 2005, Operon structure and gene expression of the espJ-tccP locus of enterohaernorrhagic Escherichia coli O157 : H7, FEMS MICROBIOLOGY LETTERS, Vol: 247, Pages: 137-145, ISSN: 0378-1097

Journal article

Liu WC, Jenkins C, Shaw DJ, Matthews L, Pearce MC, Low JC, Gunn GJ, Smith HR, Frankel G, Woolhouse MEJet al., 2005, Modelling the epidemiology of Verocytotoxin-producing Escherichia coli serogroups in young calves, EPIDEMIOLOGY AND INFECTION, Vol: 133, Pages: 449-458, ISSN: 0950-2688

Journal article

Delahay RM, Knutton S, Shaw RK, Hartland EL, Pallen MJ, Frankel Get al., 2005, The coiled-coil domain of EspA is essential for the assembly of the type III secretion translocon on the surface of enteropathogenic Escherichia coli (vol 274, pg 35969, 1999), JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 19436-19436

Journal article

Garmendia J, Frankel G, Crepin VF, 2005, Enteropathogenic and enterohemorrhagic Escherichia coli infections: Translocation, translocation, translocation, INFECTION AND IMMUNITY, Vol: 73, Pages: 2573-2585, ISSN: 0019-9567

Journal article

Crepin VF, Shaw R, Abe CM, Knutton S, Frankel Get al., 2005, Polarity of enteropathogenic Escherichia coli EspA filament assembly and protein secretion, JOURNAL OF BACTERIOLOGY, Vol: 187, Pages: 2881-2889, ISSN: 0021-9193

Journal article

Wiles S, Clare S, Harker J, Huett A, Young D, Dougan G, Frankel Get al., 2005, Organ-specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium (vol 6, pg 963, 2004), CELLULAR MICROBIOLOGY, Vol: 7, Pages: 459-459, ISSN: 1462-5814

Journal article

Crepin VF, Prasannan S, Shaw RK, Wilson RK, Creasey E, Abe CM, Knutton S, Frankel G, Matthews Set al., 2005, Structural and functional studies of the enteropathogenic Escherichia coli type III needle complex protein EscJ, MOLECULAR MICROBIOLOGY, Vol: 55, Pages: 1658-1670, ISSN: 0950-382X

Journal article

Dahan S, Wiles S, La Ragione RM, Best A, Woodward MJ, Stevens MP, Shaw RK, Chong YW, Knutton S, Phillips A, Frankel Get al., 2005, EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics, INFECTION AND IMMUNITY, Vol: 73, Pages: 679-686, ISSN: 0019-9567

Journal article

Shaw RK, Cleary J, Murphy MS, Frankel G, Knutton Set al., 2005, Interaction of enteropathogenic Escherichia coli with human intestinal mucosa: Role of effector proteins in brush border remodeling and formation of attaching and effacing lesions, INFECTION AND IMMUNITY, Vol: 73, Pages: 1243-1251, ISSN: 0019-9567

Journal article

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