Publications
277 results found
Hemrajani C, Marches O, Wiles S, et al., 2008, Role of NleH, a Type III Secreted Effector from Attaching and Effacing Pathogens, in Colonization of the Bovine, Ovine, and Murine Gut, INFECTION AND IMMUNITY, Vol: 76, Pages: 4804-4813, ISSN: 0019-9567
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- Citations: 31
Dennis A, Kudo T, Kruidenier L, et al., 2008, The p50 Subunit of NF-κB Is Critical for In Vivo Clearance of the Noninvasive Enteric Pathogen <i>Citrobacter rodentium</i>, INFECTION AND IMMUNITY, Vol: 76, Pages: 4978-4988, ISSN: 0019-9567
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- Citations: 24
Mousnier A, Whale AD, Schuller S, et al., 2008, Cortactin recruitment by enterohemorrhagic <i>Escherichia coli</i> O157:H7 during infection in vitro and ex vivo, INFECTION AND IMMUNITY, Vol: 76, Pages: 4669-4676, ISSN: 0019-9567
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- Citations: 11
Arbeloa A, Bulgin RR, MacKenzie G, et al., 2008, Subversion of actin dynamics by EspM effectors of attaching and effacing bacterial pathogens, CELLULAR MICROBIOLOGY, Vol: 10, Pages: 1429-1441, ISSN: 1462-5814
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- Citations: 62
Girard F, Frankel G, Phillips AD, et al., 2008, Interaction of enterohemorrhagic <i>Escherichia coli</i> O157:H7 with mouse intestinal mucosa, FEMS MICROBIOLOGY LETTERS, Vol: 283, Pages: 196-202, ISSN: 0378-1097
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- Citations: 9
Shaw RK, Berger CN, Feys B, et al., 2008, Enterohemorrhagic <i>Escherichia coli</i> exploits EspA filaments for attachment to salad leaves, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol: 74, Pages: 2908-2914, ISSN: 0099-2240
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- Citations: 84
Marches O, Covarelli V, Dahan S, et al., 2008, EspJ of enteropathogenic and enterohaemorrhagic <i>Escherichia coli</i> inhibits opsono-phagocytosis, CELLULAR MICROBIOLOGY, Vol: 10, Pages: 1104-1115, ISSN: 1462-5814
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- Citations: 66
Crepin VF, Martinez E, Shaw RK, et al., 2008, Structural and functional properties of chimeric EspA-FliCi filaments of EPEC, JOURNAL OF MOLECULAR BIOLOGY, Vol: 378, Pages: 243-250, ISSN: 0022-2836
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- Citations: 5
Griesenbach U, Meng C, Farley R, et al., 2008, <i>In vivo</i> imaging of gene transfer to the respiratory tract, BIOMATERIALS, Vol: 29, Pages: 1533-1540, ISSN: 0142-9612
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- Citations: 13
Singh MP, Shaw RK, Knutton S, et al., 2008, Identification of amino acid residues within the N-terminal domain of EspA that play a role in EspA filament biogenesis and function, JOURNAL OF BACTERIOLOGY, Vol: 190, Pages: 2221-2226, ISSN: 0021-9193
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- Citations: 7
Frankel G, Phillips AD, 2008, Attaching effacing <i>Escherichia coli</i> and paradigms of Tir-triggered actin polymerization:: getting off the pedestal, CELLULAR MICROBIOLOGY, Vol: 10, Pages: 549-556, ISSN: 1462-5814
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- Citations: 130
Kozub-Witkowski E, Krause G, Frankel G, et al., 2008, Serotypes and virutypes of enteropathogenic and enterohaemorrhagic <i>Escherichia coli</i> strains from stool samples of children with diarrhoea in Germany, JOURNAL OF APPLIED MICROBIOLOGY, Vol: 104, Pages: 403-410, ISSN: 1364-5072
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- Citations: 43
Iguchi A, Ooka T, Ogura Y, et al., 2008, Genomic comparison of the O-antigen biosynthesis gene clusters of <i>Escherichia coli</i> O55 strains belonging to three distinct lineages, MICROBIOLOGY-SGM, Vol: 154, Pages: 559-570, ISSN: 1350-0872
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- Citations: 18
Lee SF, Kelly M, McAlister A, et al., 2008, A C-terminal class IPDZ binding motif of EspI/NleA modulates the virulence of attaching and effacing <i>Escherichia coli</i> and <i>Citrobacter rodentium</i>, CELLULAR MICROBIOLOGY, Vol: 10, Pages: 499-513, ISSN: 1462-5814
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- Citations: 30
Lee SF, Kelly M, McAlister A, et al., 2008, A C-terminal class IPDZ binding motif of EspI/NIeA modulates the virulence of attaching and effacing Escherichia coli and Citrobacter rodentium, CELL MICROBIOL, Vol: 10, Pages: 499-513, ISSN: 1462-5814
Enteropathogenic Escherichia coli induces characteristic attaching-effacing (A/E) lesions on the intestinal mucosa during infection. The locus of enterocyte effacement is essential for A/E lesion formation and encodes a type III secretion system that translocates multiple effector proteins into the host cell. Following translocation, EspI/NIeA localizes to the Golgi. Using the yeast two-hybrid system (Y2HS) and PSD-95/Disk-large/ZO-1 (PDZ)-domain protein array overlays, we identified 15 putative host-interacting partners of Espl. All but two of the target proteins contained PDZ domains. Examination of the EspI amino acid sequence revealed a C-terminal consensus class I PDZ binding motif. Deletion of the last 7 amino acids of EspI to generate EspI(Delta C7) abrogated the Y2HS interaction between EspI and 5 of the 6 putative host cell target proteins tested. Deletion of the EspI PDZ binding motif also resulted in delayed trafficking of EspI to the Golgi. Using a mouse model of infection, we showed that Citrobacter rodentium expressing truncated EspI(Delta C7) was attenuated when in competition with C. rodentium expressing full-length EspI. Overall, these results suggested that Espl may modulate the virulence of A/E pathogens by binding host PDZ-domain proteins.
Bai L, Schuller S, Whale A, et al., 2008, Enteropathogenic <i>Escherichia coli</i> O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of nck and TccP/TccP2, INFECTION AND IMMUNITY, Vol: 76, Pages: 361-368, ISSN: 0019-9567
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- Citations: 32
Jenkins C, Evans J, Chart H, et al., 2008, <i>Escherichia coli</i> serogroup O26 -: a new look at an old adversary, JOURNAL OF APPLIED MICROBIOLOGY, Vol: 104, Pages: 14-25, ISSN: 1364-5072
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- Citations: 37
Bishop AL, Wiles S, Dougan G, et al., 2007, Cell attachment properties and infectivity of host-adapted and environmentally adapted <i>Citrobacter rodentium</i>, MICROBES AND INFECTION, Vol: 9, Pages: 1316-1324, ISSN: 1286-4579
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- Citations: 11
Dziva F, Vlisidou I, Crepin VF, et al., 2007, Vaccination of calves with EspA, a key colonisation factor of <i>Escherichia coli</i> O157:H7, induces antigen-specific humoral responses but does not confer protection against intestinal colonisation, VETERINARY MICROBIOLOGY, Vol: 123, Pages: 254-261, ISSN: 0378-1135
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- Citations: 45
Wiles S, Crepin VF, Childs G, et al., 2007, Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents, LABORATORY ANIMALS, Vol: 41, Pages: 321-328, ISSN: 0023-6772
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- Citations: 5
Mundy R, Petrovska L, Smollett K, et al., 2007, Identification of a novel <i>Citrobacter rodentium</i> type III secreted protein, EspI, and roles of this and other secreted proteins in infection (vol 72, pg 2288, 2004), INFECTION AND IMMUNITY, Vol: 75, Pages: 3686-3686, ISSN: 0019-9567
Ooka T, Vieira MAM, Ogura Y, et al., 2007, Characterization of <i>tccP2</i> carried by atypical enteropathogenic <i>Escherichia coli</i>, FEMS MICROBIOLOGY LETTERS, Vol: 271, Pages: 126-135, ISSN: 0378-1097
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- Citations: 19
Whale AD, Hernandes RT, Ooka T, et al., 2007, TccP2-mediated subversion of actin dynamics by EPEC 2 -: a distinct evolutionary lineage of enteropathogenic <i>Escherichia coli</i>, MICROBIOLOGY-SGM, Vol: 153, Pages: 1743-1755, ISSN: 1350-0872
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- Citations: 23
Schuller S, Chong Y, Lewin J, et al., 2007, Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic <i>Escherichia coli</i> during <i>ex vivo</i> colonization of human intestinal mucosa is different to cell culture models, CELLULAR MICROBIOLOGY, Vol: 9, Pages: 1352-1364, ISSN: 1462-5814
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- Citations: 46
Girard F, Dziva F, van Diemen P, et al., 2007, Adherence of enterohemorrhagic <i>Escherichia coli</i> O157, O26, and O111 strains to bovine intestinal explants ex vivo, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol: 73, Pages: 3084-3090, ISSN: 0099-2240
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- Citations: 31
Mundy R, Schuller S, Girard F, et al., 2007, Functional studies of intimin <i>in vivo</i> and <i>ex vivo</i>:: implications for host specificity and tissue tropism, MICROBIOLOGY-SGM, Vol: 153, Pages: 959-967, ISSN: 1350-0872
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- Citations: 39
van Diemen PM, Dziva F, Abu-Median A, et al., 2007, Subunit vaccines based on intimin and Efa-1 polypeptides induce humoral immunity in cattle but do not protect against intestinal colonisation by enterohaemorrhagic <i>Escherichia coli</i> O157:H7 or O26:H-, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol: 116, Pages: 47-58, ISSN: 0165-2427
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- Citations: 41
Chong Y, Fitzhenry R, Heuschkel R, et al., 2007, Human intestinal tissue tropism in <i>Escherichia coli</i> O157: H7 -: initial colonization of terminal ileum and Peyer's patches and minimal colonic adhesion <i>ex vivo</i>, MICROBIOLOGY-SGM, Vol: 153, Pages: 794-802, ISSN: 1350-0872
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- Citations: 42
Ogura Y, Ooka T, Whale A, et al., 2007, TccP2 of O157:H7 and non-O157 enterohemorrhagic <i>Escherichia coli</i> (EHEC):: Challenging the dogma of EHEC-induced actin polymerization, INFECTION AND IMMUNITY, Vol: 75, Pages: 604-612, ISSN: 0019-9567
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- Citations: 41
Mundy R, Girard F, FitzGerald AJ, et al., 2006, Comparison of colonization dynamics and pathology of mice infected with enteropathogenic <i>Escherichia coli</i>, enterohaemorrhagic <i>E-coli</i> and <i>Citrobacter rodentium</i>, FEMS MICROBIOLOGY LETTERS, Vol: 265, Pages: 126-132, ISSN: 0378-1097
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- Citations: 59
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