Publications
277 results found
Blanco-Toribio A, Muyldermans S, Frankel G, et al., 2010, Direct Injection of Functional Single-Domain Antibodies from <i>E</i>. <i>coli</i> into Human Cells, PLOS ONE, Vol: 5, ISSN: 1932-6203
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- Citations: 43
Martinez E, Schroeder GN, Berger CN, et al., 2010, Binding to Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic <i>Escherichia coli</i> type III secretion system effectors Map, EspI and NleH, CELLULAR MICROBIOLOGY, Vol: 12, Pages: 1718-1731, ISSN: 1462-5814
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- Citations: 36
Schroeder GN, Petty NK, Mousnier A, et al., 2010, <i>Legionella pneumophila</i> Strain 130b Possesses a Unique Combination of Type IV Secretion Systems and Novel Dot/Icm Secretion System Effector Proteins, JOURNAL OF BACTERIOLOGY, Vol: 192, Pages: 6001-6016, ISSN: 0021-9193
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- Citations: 90
Younis R, Bingle LEH, Rollauer S, et al., 2010, SepL Resembles an Aberrant Effector in Binding to a Class 1 Type III Secretion Chaperone and Carrying an N-Terminal Secretion Signal, JOURNAL OF BACTERIOLOGY, Vol: 192, Pages: 6093-6098, ISSN: 0021-9193
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- Citations: 22
Vossenkaemper A, Marches O, Fairclough PD, et al., 2010, Inhibition of NF-κB Signaling in Human Dendritic Cells by the Enteropathogenic <i>Escherichia coli</i> Effector Protein NleE, JOURNAL OF IMMUNOLOGY, Vol: 185, Pages: 4118-4127, ISSN: 0022-1767
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- Citations: 67
Berger CN, Sodha SV, Shaw RK, et al., 2010, Fresh fruit and vegetables as vehicles for the transmission of human pathogens, ENVIRONMENTAL MICROBIOLOGY, Vol: 12, Pages: 2385-2397, ISSN: 1462-2912
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- Citations: 594
Deacon V, Dziva F, van Diemen PM, et al., 2010, Efa-1/LifA mediates intestinal colonization of calves by enterohaemorrhagic <i>Escherichia coli</i> 026: H- in a manner independent of glycosyltransferase and cysteine protease motifs or effects on type III secretion, MICROBIOLOGY-SGM, Vol: 156, Pages: 2527-2536, ISSN: 1350-0872
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- Citations: 19
Munera D, Crepin VF, Marches O, et al., 2010, N-Terminal Type III Secretion Signal of Enteropathogenic <i>Escherichia coli</i> Translocator Proteins, JOURNAL OF BACTERIOLOGY, Vol: 192, Pages: 3534-3539, ISSN: 0021-9193
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- Citations: 29
Mitomo K, Griesenbach U, Inoue M, et al., 2010, Toward Gene Therapy for Cystic Fibrosis Using a Lentivirus Pseudotyped With Sendai Virus Envelopes, MOLECULAR THERAPY, Vol: 18, Pages: 1173-1182, ISSN: 1525-0016
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- Citations: 91
Robinson KS, Mousnier A, Hemrajani C, et al., 2010, The enteropathogenic <i>Escherichia coli</i> effector NleH inhibits apoptosis induced by <i>Clostridium difficile</i> toxin B, MICROBIOLOGY-SGM, Vol: 156, Pages: 1815-1823, ISSN: 1350-0872
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- Citations: 23
Arbeloa A, Garnett J, Lillington J, et al., 2010, EspM2 is a RhoA guanine nucleotide exchange factor, Cellular Microbiology, Vol: 12, Pages: 654-664, ISSN: 1462-5814
We investigated how the type III secretion system WxxxE effectors EspM2 of enterohaemorrhagic Escherichia coli, which triggers stress fibre formation, and SifA of Salmonella enterica serovar Typhimurium, which is involved in intracellular survival, modulate Rho GTPases. We identified a direct interaction between EspM2 or SifA and nucleotide‐free RhoA. Nuclear Magnetic Resonance Spectroscopy revealed that EspM2 has a similar fold to SifA and the guanine nucleotide exchange factor (GEF) effector SopE. EspM2 induced nucleotide exchange in RhoA but not in Rac1 or H‐Ras, while SifA induced nucleotide exchange in none of them. Mutating W70 of the WxxxE motif or L118 and I127 residues, which surround the catalytic loop, affected the stability of EspM2. Substitution of Q124, located within the catalytic loop of EspM2, with alanine, greatly attenuated the RhoA GEF activity in vitro and the ability of EspM2 to induce stress fibres upon ectopic expression. These results suggest that binding of SifA to RhoA does not trigger nucleotide exchange while EspM2 is a unique Rho GTPase GEF.
Newton HJ, Pearson JS, Badea L, et al., 2010, The Type III Effectors NleE and NleB from Enteropathogenic <i>E</i>. <i>coli</i> and OspZ from <i>Shigella</i> Block Nuclear Translocation of NF-κB p65, PLOS PATHOGENS, Vol: 6, ISSN: 1553-7366
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- Citations: 172
Bulgin R, Raymond B, Garnett JA, et al., 2010, Bacterial Guanine Nucleotide Exchange Factors SopE-Like and WxxxE Effectors, INFECTION AND IMMUNITY, Vol: 78, Pages: 1417-1425, ISSN: 0019-9567
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- Citations: 64
Hemrajani C, Berger CN, Robinson KS, et al., 2010, NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic <i>Escherichia coli</i> infection, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 3129-3134, ISSN: 0027-8424
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- Citations: 115
Chaudhuri RR, Sebaihia M, Hobman JL, et al., 2010, Complete Genome Sequence and Comparative Metabolic Profiling of the Prototypical Enteroaggregative <i>Escherichia coli</i> Strain 042, PLOS ONE, Vol: 5, ISSN: 1932-6203
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- Citations: 133
Crepin VF, Girard F, Schueller S, et al., 2010, Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways <i>in vivo</i>, MOLECULAR MICROBIOLOGY, Vol: 75, Pages: 308-323, ISSN: 0950-382X
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- Citations: 46
Bulgin R, Arbeloa A, Goulding D, et al., 2009, The T3SS Effector EspT Defines a New Category of Invasive Enteropathogenic <i>E</i>. <i>coli</i> (EPEC) Which Form Intracellular Actin Pedestals, PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366
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- Citations: 42
Petty NK, Bulgin R, Crepin VF, et al., 2009, The Citrobacter rodentium Genome Sequence Reveals Convergent Evolution with Human Pathogenic Escherichia coli, Journal of Bacteriology, Vol: 192, Pages: 525-538, ISSN: 1098-5530
Citrobacter rodentium (formally Citrobacter freundii biotype 4280) is a highly infectious pathogen that causes colitis and transmissible colonic hyperplasia in mice. In common with enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively), C. rodentium exploits a type III secretion system (T3SS) to induce attaching and effacing (A/E) lesions that are essential for virulence. Here, we report the fully annotated genome sequence of the 5.3-Mb chromosome and four plasmids harbored by C. rodentium strain ICC168. The genome sequence revealed key information about the phylogeny of C. rodentium and identified 1,585 C. rodentium-specific (without orthologues in EPEC or EHEC) coding sequences, 10 prophage-like regions, and 17 genomic islands, including the locus for enterocyte effacement (LEE) region, which encodes a T3SS and effector proteins. Among the 29 T3SS effectors found in C. rodentium are all 22 of the core effectors of EPEC strain E2348/69. In addition, we identified a novel C. rodentium effector, named EspS. C. rodentium harbors two type VI secretion systems (T6SS) (CTS1 and CTS2), while EHEC contains only one T6SS (EHS). Our analysis suggests that C. rodentium and EPEC/EHEC have converged on a common host infection strategy through access to a common pool of mobile DNA and that C. rodentium has lost gene functions associated with a previous pathogenic niche.
Frankel G, Shaw RK, Pink D, et al., 2009, Fresh produce as a potential vector for bacterial human pathogens, MICROBIAL BIOTECHNOLOGY, Vol: 2, Pages: 595-597, ISSN: 1751-7915
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- Citations: 7
Girard F, Dziva F, Stevens MP, et al., 2009, Interactions of Typical and Atypical Enteropathogenic <i>Escherichia coli</i> Strains with the Calf Intestinal Mucosa Ex Vivo, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol: 75, Pages: 5991-5995, ISSN: 0099-2240
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- Citations: 6
Arbeloa A, Blanco M, Moreira FC, et al., 2009, Distribution of <i>espM</i> and <i>espT</i> among enteropathogenic and enterohaemorrhagic <i>Escherichia coli</i>, JOURNAL OF MEDICAL MICROBIOLOGY, Vol: 58, Pages: 988-995, ISSN: 0022-2615
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- Citations: 26
Berger CN, Shaw RK, Ruiz-Perez F, et al., 2009, Interaction of enteroaggregative <i>Escherichia coli</i> with salad leaves, ENVIRONMENTAL MICROBIOLOGY REPORTS, Vol: 1, Pages: 234-239, ISSN: 1758-2229
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- Citations: 33
Griesenbach U, Meng C, Farley R, et al., 2009, The role of doxorubicin in non-viral gene transfer in the lung, BIOMATERIALS, Vol: 30, Pages: 1971-1977, ISSN: 0142-9612
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- Citations: 11
Girard F, Crepin VF, Frankel G, 2009, Modelling of Infection by Enteropathogenic <i>Escherichia coli</i> Strains in Lineages 2 and 4 Ex Vivo and In Vivo by Using <i>Citrobacter rodentium</i> Expressing TccP, INFECTION AND IMMUNITY, Vol: 77, Pages: 1304-1314, ISSN: 0019-9567
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- Citations: 10
Berger CN, Shaw RK, Brown DJ, et al., 2009, Interaction of <i>Salmonella enterica</i> with basil and other salad leaves, ISME JOURNAL, Vol: 3, Pages: 261-265, ISSN: 1751-7362
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- Citations: 93
Bulgin RR, Arbeloa A, Chung JCS, et al., 2009, EspT triggers formation of lamellipodia and membrane ruffles through activation of Rac-1 and Cdc42, CELLULAR MICROBIOLOGY, Vol: 11, Pages: 217-229, ISSN: 1462-5814
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- Citations: 52
Berger CN, Crepin VF, Jepson MA, et al., 2009, The mechanisms used by enteropathogenic <i>Escherichia coli</i> to control filopodia dynamics, CELLULAR MICROBIOLOGY, Vol: 11, Pages: 309-322, ISSN: 1462-5814
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- Citations: 53
Iguchi A, Thomson NR, Ogura Y, et al., 2009, Complete Genome Sequence and Comparative Genome Analysis of Enteropathogenic <i>Escherichia coli</i> O127:H6 Strain E2348/69, JOURNAL OF BACTERIOLOGY, Vol: 191, Pages: 347-354, ISSN: 0021-9193
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- Citations: 254
Wiles S, Robertson BD, Frankel G, et al., 2009, Bioluminescent Monitoring of In Vivo Colonization and Clearance Dynamics by Light-Emitting Bacteria, BIOLUMINESCENCE: METHODS AND PROTOCOLS, SECOND EDITION, Vol: 574, Pages: 137-153, ISSN: 1064-3745
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- Citations: 17
Hart E, Yang J, Tauschek M, et al., 2008, RegA, an AraC-Like Protein, Is a Global Transcriptional Regulator That Controls Virulence Gene Expression in <i>Citrobacter rodentium</i>, INFECTION AND IMMUNITY, Vol: 76, Pages: 5247-5256, ISSN: 0019-9567
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- Citations: 49
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