Imperial College London
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ProfessorGadFrankel

Faculty of Natural Sciences, Department of Life Sciences

Professor of Molecular Pathogenesis
 
 
 
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Contact

 

+44 (0)20 7594 5253g.frankel

 
 
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Location

 

1.46Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kreutzberger:2022:10.1038/s41467-022-29069-y,
author = {Kreutzberger, MAB and Sobe, RC and Sauder, AB and Chatterjee, S and Peña, A and Wang, F and Giron, JA and Kiessling, V and Costa, TRD and Conticello, VP and Frankel, G and Kendall, MM and Scharf, BE and Egelman, EH},
doi = {10.1038/s41467-022-29069-y},
journal = {Nature Communications},
pages = {1--13},
title = {Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.},
url = {http://dx.doi.org/10.1038/s41467-022-29069-y},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Flagellar filaments function as the propellers of the bacterial flagellum and their supercoiling is key to motility. The outer domains on the surface of the filament are non-critical for motility in many bacteria and their structures and functions are not conserved. Here, we show the atomic cryo-electron microscopy structures for flagellar filaments from enterohemorrhagic Escherichia coli O157:H7, enteropathogenic E. coli O127:H6, Achromobacter, and Sinorhizobium meliloti, where the outer domains dimerize or tetramerize to form either a sheath or a screw-like surface. These dimers are formed by 180° rotations of half of the outer domains. The outer domain sheath (ODS) plays a role in bacterial motility by stabilizing an intermediate waveform and prolonging the tumbling of E. coli cells. Bacteria with these ODS and screw-like flagellar filaments are commonly found in soil and human intestinal environments of relatively high viscosity suggesting a role for the dimerization in these environments.
AU  - Kreutzberger,MAB
AU  - Sobe,RC
AU  - Sauder,AB
AU  - Chatterjee,S
AU  - Peña,A
AU  - Wang,F
AU  - Giron,JA
AU  - Kiessling,V
AU  - Costa,TRD
AU  - Conticello,VP
AU  - Frankel,G
AU  - Kendall,MM
AU  - Scharf,BE
AU  - Egelman,EH
DO  - 10.1038/s41467-022-29069-y
EP  - 13
PY  - 2022///
SN  - 2041-1723
SP  - 1
TI  - Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-29069-y
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35301306
UR  - https://www.nature.com/articles/s41467-022-29069-y
UR  - http://hdl.handle.net/10044/1/95934
VL  - 13
ER  -
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