Publications
148 results found
BROWN K, GERSTBERGER S, CARLSON L, et al., 1995, CENTRAL OF I-KAPPA-B-ALPHA PROTEOLYSIS BY SITE-SPECIFIC, SIGNAL-INDUCED PHOSPHORYLATION, SCIENCE, Vol: 267, Pages: 1485-1488, ISSN: 0036-8075
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- Citations: 1329
Brown K, Gerstberger S, Carlson L, et al., 1995, Control of IκB-α proteolysis by site-specific signal-induced phosphorylation., Science, Vol: 267, Pages: 1485-1488
Drew PD, Franzoso G, Becker KG, et al., 1995, NF-κB and Interferon Regulatory Factor-1 physically interact and synergistically induce Major Histocompatibility Class I gene expression., J. Interf. Cytok. Res., Vol: 15, Pages: 1037-1045
Drew PD, Franzoso G, Becker KG, et al., 1995, Interferon Regulatory Factor-2 physically interacts with NF-κB and inhibits NF-κB induction of Major Histocompatibility Class I and β2-microglobulin gene expression in transfected human neuronal cells., J. Neuroimmunol., Vol: 63, Pages: 157-162
Franzoso G, Biswas P, Poli G, et al., 1994, A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the Nuclear Factor-κB subunit p65 in vitro and may impair Human Immunodeficiency Virus replication in these cells., Journal of Experimental Medicine, Vol: 180, Pages: 1445-1456, ISSN: 0022-1007
Two groups of U937 promonocytic cells were obtained by limiting dilution cloning which differed strikingly in their ability to support human immunodeficiency virus 1 (HIV-1) replication. "Plus" clones replicated the virus efficiently, whereas "minus" clones did not. We examined these clones for differences in nuclear factor (NF)-kappa B activity which might account for the observed phenomenon. Stimulation of plus clones liberated the classical p50-p65 complex from cytoplasmic pools, whereas minus clones produced an apparently novel, faster-migrating complex, as judged by electrophoretic mobility shift assays. It is surprising that the faster-migrating complex was composed also of p50 and p65. However, the p65 subunit was COOH-terminally truncated, as shown by immunoprecipitation. The truncation resulted from limited proteolysis of p65 during cellular extraction which released particular lysosomal serine proteases, such as elastase, cathepsin G, and proteinase 3. These specific proteases are coordinately expressed and were present exclusively in the minus U937 clones, but not in the plus clones, as demonstrated in the case of cathepsin G. In addition, these proteases were detected in certain subclones of THP-1 and HL-60 cells and in primary monocytes, in each case correlating with the truncated from of p65. We demonstrate in vitro cleavage of p65 by purified elastase and cathepsin G. It is possible that particular serine proteases may have inhibiting effects on the replication of HIV-1 in myelo-monocytic cells. The data also demonstrate that special precautions must be taken when making extracts from myelo-monocytic cells.
FRANZOSO G, BOURS V, AZARENKO V, et al., 1994, AN INDIRECT ROLE FOR BCL-3 IN NF-KAPPA-B-MEDIATED TRANSACTIVATION AFTER CELLULAR-STIMULATION, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 10, Pages: S96-S96, ISSN: 0889-2229
BROWN K, PARK S, KANNO T, et al., 1994, MUTUAL REGULATION OF THE TRANSCRIPTIONAL ACTIVATOR NF-KAPPA-B AND ITS INHIBITOR, I-KAPPA-B-ALPHA, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 10, Pages: S96-S96, ISSN: 0889-2229
Siebenlist U, 1994, Structure, Regulation, and Function of NF-kappaB, Annual Review of Cell and Developmental Biology, Vol: 10, Pages: 405-455, ISSN: 1081-0706
Siebenlist U, Franzoso G, Brown K, 1994, Structure, regulation and function of NF-κB., Annu. Rev. Cell Biol., Vol: 10, Pages: 405-455
Franzoso G, Hu P-C, Meloni GA, et al., 1994, Immunoblot analyses of chimpanzee sera after infection and after immunization and challenge with Mycoplasma pneumoniae., Infect. Immun., Vol: 62, Pages: 1008-1014
Kanno T, Brown K, Franzoso G, et al., 1994, Kinetic analysis of Human T-cell Leukemia Virus type I Tax-mediated activation of NF-κB., Mol. Cell. Biol., Vol: 14, Pages: 6443-6451
Siebenlist U, Brown G, Franzoso G, 1994, NF-κB: a mediator of pathogen and stress responses., Inducible Gene Expression., Pages: 93-141
Kanno T, Franzoso G, Siebenlist U, 1994, Human T cell leukemia virus type Tax-protein-mediated activation of NF-κB from p100 (NF-κB2)-inhibited cytoplasmic reservoirs., Proc. Natl. Acad. Sci. (U.S.A.), Vol: 91, Pages: 12634-12638
FRANZOSO G, BOURS V, AZARENKO V, et al., 1993, BCL-3 CAN CAUSE KAPPA-B-DEPENDENT TRANSACTIVATION BY AN INDIRECT MECHANISM, JOURNAL OF IMMUNOLOGY, Vol: 150, Pages: A205-A205, ISSN: 0022-1767
BROWN K, PARK S, KANNO T, et al., 1993, MUTUAL REGULATION OF THE TRANSCRIPTIONAL ACTIVATOR NF-KAPPA-B AND ITS INHIBITOR, I-KAPPA-B-ALPHA, CLINICAL RESEARCH, Vol: 41, Pages: A137-A137, ISSN: 0009-9279
Franzoso G, Hu P-C, Meloni GA, et al., 1993, The immunodominant 90 kilodalton protein is localized on the terminal tip structure of Mycoplasma pneumoniae., Infect. Immun., Vol: 61, Pages: 1523-1530
Segars JH, Nagata T, Bours V, et al., 1993, Retinoic acid induction of Major Histocompatibility Complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-κB (p50/p65) and Retinoic Acid Receptor β-Retinoid X Receptor β heterodimers., Mol. Cell. Biol., Vol: 13, Pages: 6157-6169
Dimitrov DS, Franzoso G, Salman M, et al., 1993, Mycoplasma fermentans (incognitus strain) cells are able to fuse with T-lymphocytes., Clin. Infect. Dis., Vol: 17, Pages: S305-S308
Bours V, Franzoso G, Azarenko V, et al., 1993, The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers., Cell, Vol: 72, Pages: 729-739
Franzoso G, Bours V, Azarenko V, et al., 1993, The oncoprotein Bcl-3 can facilitate NF-κB- mediated transactivation by removing inhibiting p50 homodimers from select κB sites., EMBO J., Vol: 12, Pages: 3893-3901
Brown K, Park S, Kanno T, et al., 1993, Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκB-α., Proc. Natl. Acad. Sci. (U.S.A.), Vol: 90, Pages: 2532-2536
Bours V, Franzoso G, Brown K, et al., 1992, Lymphocyte activation and the family of NF-κB transcription factor complexes., Curr. Top. Microbiol. Immunol., Vol: 182, Pages: 411-420
Franzoso G, Bours V, Park S, et al., 1992, The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition., Nature, Vol: 359, Pages: 339-342
Franzoso G, Dimitrov DS, Blumenthal R, et al., 1992, Fusion of Mycoplasma fermentans, strain incognitus, with T-lymphocytes., F.E.B.S. Letters, Vol: 303, Pages: 251-254
Franzoso G, Bours V, Park S, et al., 1992, The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition., Nature, Vol: 359, Pages: 339-342
Franzoso G, Cusinato R, Tonin EA, et al., 1991, [Action of ++clarithromycin against mycoplasma and chlamydia]., G Ital Chemioter, Vol: 38, Pages: 159-161, ISSN: 0017-0445
Franzoso G, Cusinato R, Tonin EA, et al., 1991, Attivita` della claritromicina nei confronti di micoplasmi e clamidie., G. Ital. Chemioter., Vol: 38, Pages: 159-161
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