Imperial College London
Portrait Picture

Professor Guido Franzoso

Faculty of Medicine, Department of Immunology and Inflammation

Chair in Inflammation and Signal Transduction
 
 
 
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Contact

 

+44 (0)20 3313 8421g.franzoso Website

 
 
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Assistant

 

Miss Anjli Jagpal +44 (0)20 3313 3152

 
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Location

 

5N1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Capece:2020:10.1016/j.semcdb.2019.05.021,
author = {Capece, D and Verzella, D and Di, Francesco B and Alesse, E and Franzoso, G and Zazzeroni, F},
doi = {10.1016/j.semcdb.2019.05.021},
journal = {Seminars in Cell and Developmental Biology},
pages = {118--128},
title = {NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond},
url = {http://dx.doi.org/10.1016/j.semcdb.2019.05.021},
volume = {98},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - NF-κB plays a pivotal role in oncogenesis. This transcription factor is best known for promoting cancer cell survival and tumour-driving inflammation. However, several lines of evidence support a crucial role for NF-κB in governing energy homeostasis and mediating cancer metabolic reprogramming. Mitochondria are central players in many metabolic processes altered in cancer. Beyond their bioenergetic activity, several facets of mitochondria biology, including mitochondrial dynamics and oxidative stress, promote and sustain malignant transformation. Recent reports revealed an intimate connection between NF-κB pathway and the oncogenic mitochondrial functions. NF-κB can impact mitochondrial respiration and mitochondrial dynamics, and, reciprocally, mitochondria can sense stress signals and convert them into cell biological responses leading to NF-κB activation. In this review we discuss their emerging reciprocal regulation and the significance of this interplay for anticancer therapy.
AU  - Capece,D
AU  - Verzella,D
AU  - Di,Francesco B
AU  - Alesse,E
AU  - Franzoso,G
AU  - Zazzeroni,F
DO  - 10.1016/j.semcdb.2019.05.021
EP  - 128
PY  - 2020///
SN  - 1084-9521
SP  - 118
TI  - NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond
T2  - Seminars in Cell and Developmental Biology
UR  - http://dx.doi.org/10.1016/j.semcdb.2019.05.021
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31132468
UR  - https://www.sciencedirect.com/science/article/pii/S1084952118301836?via%3Dihub
UR  - http://hdl.handle.net/10044/1/70678
VL  - 98
ER  -
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