Imperial College London
Portrait Picture

Professor Guido Franzoso

Faculty of Medicine, Department of Immunology and Inflammation

Chair in Inflammation and Signal Transduction
 
 
 
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Contact

 

+44 (0)20 3313 8421g.franzoso Website

 
 
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Assistant

 

Miss Anjli Jagpal +44 (0)20 3313 3152

 
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Location

 

5N1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moretti:2012:10.1016/j.biocel.2012.08.002,
author = {Moretti, M and Bennett, J and Tornatore, L and Thotakura, AK and Franzoso, G},
doi = {10.1016/j.biocel.2012.08.002},
journal = {The International Journal of Biochemistry and Cell Biology},
pages = {2238--2243},
title = {Cancer: NF-kappa B regulates energy metabolism},
url = {http://dx.doi.org/10.1016/j.biocel.2012.08.002},
volume = {44},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - NF-κB transcription factors are evolutionarily conserved, central coordinators of immune and inflammatory responses. They also play a pivotal role in oncogenesis. NF-κB exerts these functions by regulating the transcription of genes encoding many immunoregulators, inflammatory mediators and inhibitors of apoptosis. Several studies during the past few years have also underscored the key role of the IKK/NF-κB pathway in the induction and maintenance of the state of inflammation that underlies metabolic pathologies such as obesity, insulin resistance and type-2 diabetes, reflecting the co-evolution and integration of nutrient- and pathogen-sensing systems. Recent reports, however, are revealing an even more intimate, direct connection between NF-κB and metabolism. These studies demonstrate that NF-κB regulates energy homeostasis via direct engagement of the cellular networks governing glycolysis and respiration, with profound implications that extend beyond metabolic pathologies, to cellular physiology, cancer, and anti-cancer therapy. In this review article, we discuss these emerging metabolic functions of NF-κB and their significance to oncogenesis and cancer treatment.
AU  - Moretti,M
AU  - Bennett,J
AU  - Tornatore,L
AU  - Thotakura,AK
AU  - Franzoso,G
DO  - 10.1016/j.biocel.2012.08.002
EP  - 2243
PY  - 2012///
SN  - 1357-2725
SP  - 2238
TI  - Cancer: NF-kappa B regulates energy metabolism
T2  - The International Journal of Biochemistry and Cell Biology
UR  - http://dx.doi.org/10.1016/j.biocel.2012.08.002
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000311922500017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1357272512002804?via%3Dihub
VL  - 44
ER  -
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