Imperial College London
Portrait Picture

Professor Guido Franzoso

Faculty of Medicine, Department of Immunology and Inflammation

Chair in Inflammation and Signal Transduction
 
 
 
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Contact

 

+44 (0)20 3313 8421g.franzoso Website

 
 
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Assistant

 

Miss Anjli Jagpal +44 (0)20 3313 3152

 
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Location

 

5N1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Begalli:2017:10.3390/biomedicines5030050,
author = {Begalli, F and Bennett, J and Capece, D and Verzella, D and D'Andrea, D and Tornatore, L and Franzoso, G},
doi = {10.3390/biomedicines5030050},
journal = {Biomedicines},
title = {Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.},
url = {http://dx.doi.org/10.3390/biomedicines5030050},
volume = {5},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Transcription factors of the nuclear factor κB (NF-κB) family are central coordinating regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB activation also contributes to the pathogenesis of some of the most common current threats to global human health, including chronic inflammatory diseases, autoimmune disorders, diabetes, vascular diseases and the majority of cancers. Accordingly, the NF-κB pathway is widely considered an attractive therapeutic target in a broad range of malignant and non-malignant diseases. Yet, despite the aggressive efforts by the pharmaceutical industry to develop a specific NF-κB inhibitor, none has been clinically approved, due to the dose-limiting toxicities associated with the global suppression of NF-κB. In this review, we summarise the main strategies historically adopted to therapeutically target the NF-κB pathway with an emphasis on oncology, and some of the emerging strategies and newer agents being developed to pharmacologically inhibit this pathway.
AU  - Begalli,F
AU  - Bennett,J
AU  - Capece,D
AU  - Verzella,D
AU  - D'Andrea,D
AU  - Tornatore,L
AU  - Franzoso,G
DO  - 10.3390/biomedicines5030050
PY  - 2017///
SN  - 2227-9059
TI  - Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.
T2  - Biomedicines
UR  - http://dx.doi.org/10.3390/biomedicines5030050
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28829404
UR  - http://hdl.handle.net/10044/1/50398
VL  - 5
ER  -
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