Imperial College London
Portrait Picture

Professor Guido Franzoso

Faculty of Medicine, Department of Immunology and Inflammation

Chair in Inflammation and Signal Transduction
 
 
 
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Contact

 

+44 (0)20 3313 8421g.franzoso Website

 
 
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Assistant

 

Miss Anjli Jagpal +44 (0)20 3313 3152

 
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Location

 

5N1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Verzella:2018:10.1158/0008-5472.CAN-17-1833,
author = {Verzella, D and Bennett, J and Fischietti, M and Thotakura, AK and Recordati, C and Pasqualini, F and Capece, D and Vecchiotti, D and D'Andrea, D and Di, Francesco B and De, Maglie M and Begalli, F and Tornatore, L and Papa, S and Lawrence, T and Forbes, SJ and Sica, A and Alesse, E and Zazzeroni, F and Franzoso, G},
doi = {10.1158/0008-5472.CAN-17-1833},
journal = {Cancer Research},
pages = {1275--1292},
title = {GADD45β loss ablates innate immunosuppression in cancer},
url = {http://dx.doi.org/10.1158/0008-5472.CAN-17-1833},
volume = {78},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - T cell exclusion from the tumour microenvironment (TME) is a major barrier to overcoming immune escape.  Here we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumour-associated inflammation and T cell trafficking into tumours.  In various models of solid cancers refractory to immunotherapies, including hepatocellular carcinoma (HCC) and ovarian adenocarcinoma, Gadd45b inhibition in myeloid cells restored activation of pro-inflammatory tumour-associated macrophages (TAM) and intratumoural immune infiltration, thereby diminishing oncogenesis.  Our results provide a basis to interpret clinical evidence that elevated expression of GADD45B confers poor clinical outcomes in most human cancers.  Further, they suggest a therapeutic target in GADD45β for re-programming TAM to overcome immunosuppression and T cell exclusion from the TME.
AU  - Verzella,D
AU  - Bennett,J
AU  - Fischietti,M
AU  - Thotakura,AK
AU  - Recordati,C
AU  - Pasqualini,F
AU  - Capece,D
AU  - Vecchiotti,D
AU  - D'Andrea,D
AU  - Di,Francesco B
AU  - De,Maglie M
AU  - Begalli,F
AU  - Tornatore,L
AU  - Papa,S
AU  - Lawrence,T
AU  - Forbes,SJ
AU  - Sica,A
AU  - Alesse,E
AU  - Zazzeroni,F
AU  - Franzoso,G
DO  - 10.1158/0008-5472.CAN-17-1833
EP  - 1292
PY  - 2018///
SN  - 1538-7445
SP  - 1275
TI  - GADD45β loss ablates innate immunosuppression in cancer
T2  - Cancer Research
UR  - http://dx.doi.org/10.1158/0008-5472.CAN-17-1833
UR  - http://hdl.handle.net/10044/1/55461
VL  - 78
ER  -
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