Imperial College London
Alternate

DrGeorgiosGiamas

Faculty of Medicine, Department of Surgery & Cancer

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 2804g.giamas Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lane:2019:10.1038/s42003-019-0560-x,
author = {Lane, R and Simon, T and Vintu, M and Solkin, B and Koch, B and Stewart, N and Benstead-Hume, G and Pearl, FMG and Critchley, G and Stebbing, J and Giamas, G},
doi = {10.1038/s42003-019-0560-x},
journal = {Commun Biol},
title = {Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping.},
url = {http://dx.doi.org/10.1038/s42003-019-0560-x},
volume = {2},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options and biomarkers are limited. Small extracellular vesicles (sEVs) produced by both GBM and stromal cells are central in the inter-cellular communication that is taking place in the tumor bulk. As tumor sEVs are accessible in biofluids, recent reports have suggested that sEVs contain valuable biomarkers for GBM patient diagnosis and follow-up. The aim of the current study was to describe the protein content of sEVs produced by different GBM cell lines and patient-derived stem cells. Our results reveal that the content of the sEVs mirrors the phenotypic signature of the respective GBM cells, leading to the description of potential informative sEV-associated biomarkers for GBM subtyping, such as CD44. Overall, these data could assist future GBM in vitro studies and provide insights for the development of new diagnostic and therapeutic methods as well as personalized treatment strategies.
AU  - Lane,R
AU  - Simon,T
AU  - Vintu,M
AU  - Solkin,B
AU  - Koch,B
AU  - Stewart,N
AU  - Benstead-Hume,G
AU  - Pearl,FMG
AU  - Critchley,G
AU  - Stebbing,J
AU  - Giamas,G
DO  - 10.1038/s42003-019-0560-x
PY  - 2019///
TI  - Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping.
T2  - Commun Biol
UR  - http://dx.doi.org/10.1038/s42003-019-0560-x
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31925112
VL  - 2
ER  -
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