14 results found
Geissmann Q, Rodriguez LG, Beckwith EJ, et al., 2019, Rethomics: An R framework to analyse high-throughput behavioural data, PLOS ONE, Vol: 14, ISSN: 1932-6203
Geissmann Q, Beckwith E, Gilestro G, 2018, Most sleep does not serve a vital function. Evidence from Drosophila melanogaster
Sleep appears to be a universally conserved phenomenon among the animal kingdom but whether this striking evolutionary conservation underlies a basic vital function is still an open question. Using novel technologies, we conducted an unprecedentedly detailed high-throughput analysis of sleep in the fruit fly Drosophila melanogaster, coupled with a life-long chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type Drosophila melanogaster. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. We propose a three-partite model framework of sleep function, according to which, total sleep accounts for three components: a vital component, a useful component, and an accessory component.
Geissmann Q, Rodriguez LG, Beckwith EJ, et al., 2017, Ethoscopes: An open platform for high-throughput ethomics, PLOS BIOLOGY, Vol: 15, ISSN: 1545-7885
Gilestro GF, 2012, Video tracking and analysis of sleep in Drosophila melanogaster, NATURE PROTOCOLS, Vol: 7, Pages: 995-1007, ISSN: 1754-2189
Gilestro GF, Cirelli C, 2010, pySolo
pySolo is a multiplatform software for analysis of sleep and locomotor activity in Drosophila melanogaster. pySolo provides a user-friendly graphic interface and it has been developed with the specific aim of being accessible, portable, fast and easily expandable through an intuitive plug-in structure. Support for development of additional plug-ins is provided through a community website. AVAILABILITY: Software and documentation are located at (http://www.pysolo.net). pySolo is a free software released under the GNU General Public License.
Gilestro GF, Cirelli C, 2009, pySolo: a complete suite for sleep analysis in Drosophila, BIOINFORMATICS, Vol: 25, Pages: 1466-1467, ISSN: 1367-4803
Gilestro GF, Tononi G, Cirelli C, 2009, Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila, SCIENCE, Vol: 324, Pages: 109-112, ISSN: 0036-8075
Gilestro GF, 2008, Redundant Mechanisms for Regulation of Midline Crossing in Drosophila, PLOS ONE, Vol: 3, ISSN: 1932-6203
Dickson BJ, Gilestro GF, 2006, Regulation of commissural axon pathfinding by slit and its robo receptors, ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, Vol: 22, Pages: 651-675, ISSN: 1081-0706
Christensen C, Ambartsumian N, Gilestro G, et al., 2005, Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis, CANCER RESEARCH, Vol: 65, Pages: 6167-6177, ISSN: 0008-5472
Artigiani S, Conrotto P, Fazzari P, et al., 2004, Plexin-B3 is a functional receptor for semaphorin 5A, EMBO REPORTS, Vol: 5, Pages: 710-714, ISSN: 1469-221X
Giordano S, Corso S, Conrotto P, et al., 2002, The Semaphorin 4D receptor controls invasive growth by coupling with Met, NATURE CELL BIOLOGY, Vol: 4, Pages: 720-724, ISSN: 1465-7392
Petrelli A, Gilestro GF, Lanzardo S, et al., 2002, The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met, NATURE, Vol: 416, Pages: 187-190, ISSN: 0028-0836
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