Imperial College London

Giorgio F. Gilestro

Faculty of Natural SciencesDepartment of Life Sciences

Lecturer in Systems Biology
 
 
 
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Contact

 

+44 (0)20 7594 5443g.gilestro Website CV

 
 
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Location

 

408Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

14 results found

Geissmann Q, Rodriguez LG, Beckwith EJ, Gilestro GFet al., 2019, Rethomics: An R framework to analyse high-throughput behavioural data, PLOS ONE, Vol: 14, ISSN: 1932-6203

JOURNAL ARTICLE

Geissmann Q, Beckwith E, Gilestro G, 2018, Most sleep does not serve a vital function. Evidence from Drosophila melanogaster

Sleep appears to be a universally conserved phenomenon among the animal kingdom but whether this striking evolutionary conservation underlies a basic vital function is still an open question. Using novel technologies, we conducted an unprecedentedly detailed high-throughput analysis of sleep in the fruit fly Drosophila melanogaster, coupled with a life-long chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type Drosophila melanogaster. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. We propose a three-partite model framework of sleep function, according to which, total sleep accounts for three components: a vital component, a useful component, and an accessory component.

JOURNAL ARTICLE

Geissmann Q, Rodriguez LG, Beckwith EJ, French AS, Jamasb AR, Gilestro GFet al., 2017, Ethoscopes: An open platform for high-throughput ethomics, PLOS BIOLOGY, Vol: 15, ISSN: 1545-7885

JOURNAL ARTICLE

Beckwith EJ, Geissmann Q, French AS, Gilestro GFet al., 2017, Regulation of sleep homeostasis by sexual arousal, ELIFE, Vol: 6, ISSN: 2050-084X

JOURNAL ARTICLE

Gilestro GF, 2012, Video tracking and analysis of sleep in Drosophila melanogaster, NATURE PROTOCOLS, Vol: 7, Pages: 995-1007, ISSN: 1754-2189

JOURNAL ARTICLE

Gilestro GF, Cirelli C, 2010, pySolo

pySolo is a multiplatform software for analysis of sleep and locomotor activity in Drosophila melanogaster. pySolo provides a user-friendly graphic interface and it has been developed with the specific aim of being accessible, portable, fast and easily expandable through an intuitive plug-in structure. Support for development of additional plug-ins is provided through a community website. AVAILABILITY: Software and documentation are located at (http://www.pysolo.net). pySolo is a free software released under the GNU General Public License.

SOFTWARE

Gilestro GF, Cirelli C, 2009, pySolo: a complete suite for sleep analysis in Drosophila, BIOINFORMATICS, Vol: 25, Pages: 1466-1467, ISSN: 1367-4803

JOURNAL ARTICLE

Gilestro GF, Tononi G, Cirelli C, 2009, Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila, SCIENCE, Vol: 324, Pages: 109-112, ISSN: 0036-8075

JOURNAL ARTICLE

Gilestro GF, 2008, Redundant Mechanisms for Regulation of Midline Crossing in Drosophila, PLOS ONE, Vol: 3, ISSN: 1932-6203

JOURNAL ARTICLE

Dickson BJ, Gilestro GF, 2006, Regulation of commissural axon pathfinding by slit and its robo receptors, ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, Vol: 22, Pages: 651-675, ISSN: 1081-0706

JOURNAL ARTICLE

Christensen C, Ambartsumian N, Gilestro G, Thomsen B, Comoglio P, Tamagnone L, Guldberg P, Lukanidin Eet al., 2005, Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis, CANCER RESEARCH, Vol: 65, Pages: 6167-6177, ISSN: 0008-5472

JOURNAL ARTICLE

Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone Let al., 2004, Plexin-B3 is a functional receptor for semaphorin 5A, EMBO REPORTS, Vol: 5, Pages: 710-714, ISSN: 1469-221X

JOURNAL ARTICLE

Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L, Comoglio PMet al., 2002, The Semaphorin 4D receptor controls invasive growth by coupling with Met, NATURE CELL BIOLOGY, Vol: 4, Pages: 720-724, ISSN: 1465-7392

JOURNAL ARTICLE

Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano Set al., 2002, The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met, NATURE, Vol: 416, Pages: 187-190, ISSN: 0028-0836

JOURNAL ARTICLE

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