Imperial College London
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Giorgio F. Gilestro

Faculty of Natural Sciences, Department of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5443g.gilestro Website

 
 
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Location

 

408Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Geissmann:2019:10.1126/sciadv.aau9253,
author = {Geissmann, Q and Beckwith, E and Gilestro, G},
doi = {10.1126/sciadv.aau9253},
journal = {Science Advances},
pages = {1--10},
title = {Most sleep does not serve a vital function: evidence from Drosophila melanogaster},
url = {http://dx.doi.org/10.1126/sciadv.aau9253},
volume = {5},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sleep appears to be a universally conserved phenomenon among the animal kingdom but whether this striking evolutionary conservation underlies a basic vital function is still an open question. Using a machine-learning based video-tracking technology, we conducted a detailed high-throughput analysis of sleep in the fruit fly Drosophila melanogaster,coupled with a life-long chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type Drosophila melanogaster. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. These results offer a new perspective on the biological role of sleep in Drosophilaand, potentially, in other species.
AU  - Geissmann,Q
AU  - Beckwith,E
AU  - Gilestro,G
DO  - 10.1126/sciadv.aau9253
EP  - 10
PY  - 2019///
SN  - 2375-2548
SP  - 1
TI  - Most sleep does not serve a vital function: evidence from Drosophila melanogaster
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.aau9253
UR  - https://advances.sciencemag.org/content/5/2/eaau9253/
UR  - http://hdl.handle.net/10044/1/66653
VL  - 5
ER  -
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