Imperial College London
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Giorgio F. Gilestro

Faculty of Natural Sciences, Department of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5443g.gilestro Website

 
 
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Location

 

408Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Geissmann:2018:10.1101/361667,
author = {Geissmann, Q and Beckwith, EJ and Gilestro, GF},
doi = {10.1101/361667},
title = {Most sleep does not serve a vital function. Evidence from <i>Drosophila melanogaster</i>},
url = {http://dx.doi.org/10.1101/361667},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Abstract</jats:title><jats:p>Sleep appears to be a universally conserved phenomenon among the animal kingdom but whether this striking evolutionary conservation underlies a basic vital function is still an open question. Using novel technologies, we conducted an unprecedentedly detailed high-throughput analysis of sleep in the fruit fly <jats:italic>Drosophila melanogaster</jats:italic>, coupled with a life-long chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type <jats:italic>Drosophila melanogaster</jats:italic>. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. We propose a three-partite model framework of sleep function, according to which, total sleep accounts for three components: a vital component, a useful component, and an accessory component.</jats:p>
AU  - Geissmann,Q
AU  - Beckwith,EJ
AU  - Gilestro,GF
DO  - 10.1101/361667
PY  - 2018///
TI  - Most sleep does not serve a vital function. Evidence from <i>Drosophila melanogaster</i>
UR  - http://dx.doi.org/10.1101/361667
ER  -
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