Publications
77 results found
Murray HE, Rantle CM, Simonian SX, et al., 1999, Sexually dimorphic ontogeny of GABAergic influences on periventricular somatostatin neurons, NEUROENDOCRINOLOGY, Vol: 70, Pages: 384-391, ISSN: 0028-3835
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- Citations: 15
Christian M, Gillies G, 1999, Developing hypothalamic dopaminergic neurones as potential targets for environmental estrogens, JOURNAL OF ENDOCRINOLOGY, Vol: 160, Pages: R1-R6, ISSN: 0022-0795
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- Citations: 29
Christian M, Gillies G, 1999, Effects of β17β-oestradiol and environmental oestrogens on developing rat hypothalamic dopaminergic neurones in culture, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 126, Pages: U76-U76, ISSN: 0007-1188
Murray HE, Simonian SX, Herbison AE, et al., 1999, Ontogeny and sexual differentiation of somatostatin biosynthesis and secretion in the hypothalamic periventricular-median eminence pathway, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 11, Pages: 35-42, ISSN: 0953-8194
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- Citations: 12
Murray HE, Simonian SX, Herbison AE, et al., 1999, Correlation of hypothalamic somatostatin mRNA expression and peptide content with secretion: Sexual dimorphism and differential regulation by gonadal factors, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 11, Pages: 27-33, ISSN: 0953-8194
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- Citations: 23
Simonian SX, Murray HE, Gillies GE, et al., 1998, Estrogen-dependent ontogeny of sex differences in somatostatin neurons of the hypothalamic periventricular nucleus, ENDOCRINOLOGY, Vol: 139, Pages: 1420-1428, ISSN: 0013-7227
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- Citations: 28
Buckingham JC, Cowell AM, Gillies GE, et al., 1997, The Neuroendocrine System: Anatomy, Physiology and Response to Stress., Stress, Stress Hormones and the Immune System, Editors: Buckingham, Gillies, Cowell, Publisher: John Wiley & Sons, Pages: 9-49
Murray HE, Gillies GE, 1997, Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 9, Pages: 287-295, ISSN: 0953-8194
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- Citations: 38
Gillies G, 1997, Somatostatin: the neuroendocrine story., Trends Pharmacol Sci, Vol: 18, Pages: 87-95, ISSN: 0165-6147
Since its original discovery as the neuroendocrine hormone responsible for inhibiting growth hormone (GH) secretion, our understanding of the functions of somatostatin [or somatotrophin release inhibitory hormone (SRIH)], both in the periphery and the CNS, has grown enormously. With the cloning of five SRIH receptors, much interest has centred recently on the potential use of SRIH analogues in the treatment of clinical conditions ranging from human cancers to Alzheimer's and Parkinson's diseases. There is a growing recognition that the physiological functions of GH also need to be extended beyond its role in growth control, e.g. to a role in the maintenance of normal immune, cardiovascular and reproductive functions. Here, Glenda Gillies addresses the importance of somatostatinergic systems in regulating the sexually dimorphic patterns of GH secretion as well as their influence on other endocrine hormones. She also considers the neurotransmitter/neuromodulator actions of SRIH within the hypothalamus, where it is involved in the neural control and integration of many aspects of endocrine function, as well as its potential role in the maturation of the hypothalamus during the critical perinatal period.
Gillies GE, Davidson K, Murray HE, et al., 1996, Gonadal steroids and hypothalamic neuronal development, Scientific Meeting of the Physiological-Society, Publisher: CAMBRIDGE UNIV PRESS, Pages: S10-S11, ISSN: 0022-3751
MURRAY HE, GILLIES GE, 1995, NEGATIVE ALLOSTERIC MODULATION AT GABA RECEPTORS AND SOMATOSTATIN SECRETION, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 114, Pages: P301-P301, ISSN: 0007-1188
Gillies GE, Buckingham JC, 1995, The application of in vitro models of hypothalamic function in toxicity testing., Methods Mol Biol, Vol: 43, Pages: 95-107, ISSN: 1064-3745
Gillies GE, Buckingham JC, 1995, The application of in vitro models of anterior pituitary function in toxicity testing., Methods Mol Biol, Vol: 43, Pages: 81-93, ISSN: 1064-3745
DAVIDSON K, GILLIES GE, 1994, NOVEL ACTIONS OF A BENZODIAZEPINE AND A BARBITURATE ON SOMATOSTATIN RELEASE FROM THE PERINATAL HYPOTHALAMUS IN CULTURE, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 112, Pages: U135-U135, ISSN: 0007-1188
HOFFMAN S, MURRAY HE, RANTLE C, et al., 1994, INVESTIGATIONS ON THE UPTAKE AND RELEASE OF [H-3] GABA FROM PERINATAL HYPOTHALAMUS IN PRIMARY-CELL CULTURE, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 112, Pages: U135-U135, ISSN: 0007-1188
Currie IS, Gillies GE, Brooks AN, 1994, Modulation of arginine vasopressin secretion from cultured ovine hypothalamic cells by glucocorticoids and opioid peptides, Neuroendocrinology 60, (1994), 360-366., Vol: 60, Pages: 360-366
MURRAY HE, GILLIES GE, 1993, INVESTIGATION OF THE ONTOGENIC PATTERNS OF RAT HYPOTHALAMIC DOPAMINERGIC NEURON MORPHOLOGY AND FUNCTION IN-VITRO, JOURNAL OF ENDOCRINOLOGY, Vol: 139, Pages: 403-+, ISSN: 0022-0795
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- Citations: 14
Murray HE, Gillies GE, 1993, Investigation of the ontogenetic patterns of rat hypothalamic dopaminergic neurone morphology and function in vitro., J Endocrinol, Vol: 139, Pages: 403-414, ISSN: 0022-0795
Using fetal rat hypothalamic cells in primary culture maintained in a serum-free defined medium we have investigated the morphological and functional development of the dopamine (DA)-containing neurones intrinsic to the hypothalamus. Immunocytochemical studies demonstrated the presence of three morphologically distinct subtypes of tyrosine hydroxylase-immunopositive neurones. On day 3 in vitro unipolar, bipolar and multipolar cell types were apparent. The latter two subtypes persisted to later days in culture and increased both in perikarya size and neurite length. All subtypes have been shown to have correlates in vivo. Biochemical studies employing [3H]DA demonstrated a time- and temperature-dependent uptake mechanism within the cultures which was significantly attenuated by the uptake inhibitors benztropine and nomifensine in a dose-dependent manner. [3H]DA was also released under both basal and 56 mmol K+/l-stimulated conditions and the magnitude of the response was reduced by exclusion of calcium from the release medium. The amount of [3H]DA accumulated and released by the cultural cells increased with the age of the culture, suggesting functional maturation of the DA-containing neurones within this preparation. The role of oestradiol-17 beta in regulating hypothalamic dopaminergic function was also investigated both indirectly with the use of [3H]DA and by direct measurement of endogenously synthesized DA using high-performance liquid chromatography coupled with electrochemical detection. Both uptake and release of [3H] and release of endogenous DA were significantly modulated by the concentration of steroid in the defined medium. These results demonstrate that hypothalamic dopaminergic neurones, when maintained in primary culture, undergo morphological and functional maturation which have several correlates in vivo. In addition, we have demonstrated that at least one sub-population of dopaminergic neurones within this preparation is responsive to oestradiol-1
DAVIDSON K, GILLIES GE, 1993, NEURONAL VS GLIAL SOMATOSTATIN IN THE HYPOTHALAMUS - A CELL-CULTURE STUDY OF THE ONTOGENY OF CELLULAR LOCATION, CONTENT AND RELEASE, BRAIN RESEARCH, Vol: 624, Pages: 75-84, ISSN: 0006-8993
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- Citations: 14
Hannah M, Jackson S, Gillies GE, et al., 1993, Met-enkephalin secretion from mixed cultures of hypothalamic neurons and astrocytes, Neuroendocrinology, Vol: 57, Pages: 884-891
Gillies GE, Davidson K, 1992, GABAergic influences on somatostatin secretion from hypothalamic neurones cultured in defined medium, Neuroendocrinology, Vol: 55, Pages: 248-256
GILLIES GE, GULDENAAR S, DAVIDSON K, 1991, INTERACTIONS BETWEEN GABAERGIC AND SOMATOSTATIN-PRODUCING CELLS IN CULTURES OF FETAL-RAT HYPOTHALAMI, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 438, Pages: P52-P52, ISSN: 0022-3751
Tsagarakis S, Gillies GE, Rees LH, et al., 1989, Interleukin-1 directly stimulates the release of corticotrophin releasing factor from the rat hypothalamus in vitro., Endocrinology, Vol: 123, Pages: 1962-1969
Clarke MJO, Gillies GE, 1988, Comparison of peptide release from fetal rat hypothalamic neurones cultured in defined medium and serum-containing medium, Journal of Endocrinology, Vol: 116, Pages: 349-356
Clarke MJO, Lowry PJ, Gillies GE, 1987, Assessment of corticotropin releasing factor, vasopressin and somatostatin secretion by fetal hypothalamic neurones in culture, Neuroendocrinology, Vol: 46, Pages: 147-154
Lowry PJ, Estivarez FE, Gillies GE, et al., 1986, CRF: its regulation of ACTH and pro-opiomelanocortin peptide release and its extra hypothalamic occurrence., Acta Endocrinol Suppl (Copenh)., Vol: 276, Pages: 56-62
Gillies GE, Grossman A, 1985, The CRFs and their control: Chemistry, Physiology and clinical implications., Clinics in Endocrinology and Metabolism., Vol: 14, Pages: 821-845
Gillies GE, Puri A, Hodgkinson S, et al., 1984, Involvement of rat CRF-41 and vasopressin in ACTH releasing activity from superfused rat hypothalami in vitro., Journal of Endocrinology, Vol: 103, Pages: 25-29
Gillies GE, Puri A, Linton EA, et al., 1984, Comparative chromatography of hypothalamic corticotropin-releasing factors., Neuroendocrinology, Vol: 36, Pages: 17-24
Linton EA, Gillies GE, Lowry PJ, 1983, Ovine CRF and vasopressin: Antibody-quenching studies on hypothalamic extract of normal and Brattleboro rat., Endocrinology, Vol: 113, Pages: 1878-1884
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