Imperial College London
Alternate

ProfessorGeorgiosKassiotis

Faculty of Medicine, Department of Infectious Disease

Professor of Retrovirology
 
 
 
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Contact

 

g.kassiotis Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

100 results found

Young GR, Kassiotis G, Stoye JP, 2012, <i>Emv2</i>, the only endogenous ecotropic murine leukemia virus of C57BL/6J mice, RETROVIROLOGY, Vol: 9

Journal article

Nair S, Bayer W, Ploquin MJY, Kassiotis G, Hasenkrug KJ, Dittmer Uet al., 2011, Distinct roles of CD4<SUP>+</SUP> T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model, RETROVIROLOGY, Vol: 8

Journal article

Ploquin MJ-Y, Eksmond U, Kassiotis G, 2011, B Cells and TCR Avidity Determine Distinct Functions of CD4<SUP>+</SUP> T Cells in Retroviral Infection, JOURNAL OF IMMUNOLOGY, Vol: 187, Pages: 3321-3330, ISSN: 0022-1767

Journal article

Antunes I, Kassiotis G, 2010, Suppression of Innate Immune Pathology by Regulatory T Cells during Influenza A Virus Infection of Immunodeficient Mice, JOURNAL OF VIROLOGY, Vol: 84, Pages: 12564-12575, ISSN: 0022-538X

Journal article

Nair SR, Zelinskyy G, Schimmer S, Gerlach N, Kassiotis G, Dittmer Uet al., 2010, Mechanisms of control of acute Friend virus infection by CD4<SUP>+</SUP> T helper cells and their functional impairment by regulatory T cells, JOURNAL OF GENERAL VIROLOGY, Vol: 91, Pages: 440-451, ISSN: 0022-1317

Journal article

Pike R, Filby A, Ploquin MJ-Y, Urszula E, Marques R, Antunes I, Hasenkrug K, Kassiotis Get al., 2009, Race between Retroviral Spread and CD4<SUP>+</SUP> T-Cell Response Determines the Outcome of Acute Friend Virus Infection, JOURNAL OF VIROLOGY, Vol: 83, Pages: 11211-11222, ISSN: 0022-538X

Journal article

Kassiotis G, O'Garra A, 2009, Establishing the Follicular Helper Identity, IMMUNITY, Vol: 31, Pages: 450-452, ISSN: 1074-7613

Journal article

Marques R, Williams A, Eksmond U, Wullaert A, Killeen N, Pasparakis M, Kioussis D, Kassiotis Get al., 2009, Generalized immune activation as a direct result of activated CD4+ T cell killing., J Biol, Vol: 8

BACKGROUND: In addition to progressive CD4(+) T cell immune deficiency, HIV infection is characterized by generalized immune activation, thought to arise from increased microbial exposure resulting from diminishing immunity. RESULTS: Here we report that, in a virus-free mouse model, conditional ablation of activated CD4(+) T cells, the targets of immunodeficiency viruses, accelerates their turnover and produces CD4(+) T cell immune deficiency. More importantly, activated CD4(+) T cell killing also results in generalized immune activation, which is attributable to regulatory CD4(+) T cell insufficiency and preventable by regulatory CD4(+) T cell reconstitution. Immune activation in this model develops independently of microbial exposure. Furthermore, microbial translocation in mice with conditional disruption of intestinal epithelial integrity affects myeloid but not T cell homeostasis. CONCLUSIONS: Although neither ablation of activated CD4(+) T cells nor disruption of intestinal epithelial integrity in mice fully reproduces every aspect of HIV-associated immune dysfunction in humans, ablation of activated CD4(+) T cells, but not disruption of intestinal epithelial integrity, approximates the two key immune alterations in HIV infection: CD4(+) T cell immune deficiency and generalized immune activation. We therefore propose activated CD4(+) T cell killing as a common etiology for both immune deficiency and activation in HIV infection.

Journal article

Antunes I, Tolaini M, Kissenpfennig A, Iwashiro M, Kuribayashi K, Malissen B, Hasenkrug K, Kassiotis Get al., 2008, Retrovirus-Specificity of Regulatory T Cells Is Neither Present nor Required in Preventing Retrovirus-Induced Bone Marrow Immune Pathology, IMMUNITY, Vol: 29, Pages: 782-794, ISSN: 1074-7613

Journal article

Marques R, Antunes I, Eksmond U, Stoye J, Hasenkrug K, Kassiotis Get al., 2008, B lymphocyte activation by coinfection prevents immune control of Friend virus infection, JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 3432-3440, ISSN: 0022-1767

Journal article

Kassiotis G, O'Garra A, 2008, Immunology - Immunity benefits from a little suppression, SCIENCE, Vol: 320, Pages: 1168-1169, ISSN: 0036-8075

Journal article

De Riva A, Bourgeois C, Kassiotis G, Stockinger Bet al., 2007, Noncognate interaction with MHC class II molecules is essential for maintenance of T cell metabolism to establish optimal memory CD4 T cell function, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 5488-5495, ISSN: 0022-1767

Journal article

Kassiotis G, Gray D, Kiafard Z, Zwirner J, Stockinger Bet al., 2006, Functional specialization of memory Th cells revealed by expression of integrin CD49b, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 968-975, ISSN: 0022-1767

Journal article

Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DWet al., 2006, Onset and progression in inherited ALS determined by motor neurons and microglia, SCIENCE, Vol: 312, Pages: 1389-1392, ISSN: 0036-8075

Journal article

Stockinger B, Bourgeois C, Kassiotis G, 2006, CD4<SUP>+</SUP> memory T cells:: functional differentiation and homeostasis, IMMUNOLOGICAL REVIEWS, Vol: 211, Pages: 39-48, ISSN: 0105-2896

Journal article

Hövelmeyer N, Hao ZY, Kranidioti K, Kassiotis G, Buch T, Frommer F, von Hoch L, Kramer D, Minichiello L, Kollias G, Lassmann H, Waisman Aet al., 2005, Apoptosis of oligodendrocytes via fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 5875-5884, ISSN: 0022-1767

Journal article

Bourgeois C, Kassiotis G, Stockinger B, 2005, A major role for memory CD4 T cells in the control of lymphopenia-induced proliferation of naive CD4 T cells, JOURNAL OF IMMUNOLOGY, Vol: 174, Pages: 5316-5323, ISSN: 0022-1767

Journal article

Kassiotis G, Stockinger B, 2004, Anatomical heterogeneity of memory CD4<SUP>+</SUP> T cells due to reversible adaptation to the microenvironment, JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 7292-7298, ISSN: 0022-1767

Journal article

Stockinger B, Kassiotis G, Bourgeois C, 2004, Homeostasis and T cell regulation, CURRENT OPINION IN IMMUNOLOGY, Vol: 16, Pages: 775-779, ISSN: 0952-7915

Journal article

Stockinger B, Kassiotis G, Bourgeois C, 2004, CD4 T-cell memory, SEMINARS IN IMMUNOLOGY, Vol: 16, Pages: 295-303, ISSN: 1044-5323

Journal article

Stockinger B, Barthlott T, Kassiotis G, 2004, The concept of space and competition in immune regulation, IMMUNOLOGY, Vol: 111, Pages: 241-247, ISSN: 0019-2805

Journal article

Kassiotis G, Zamoyska R, Stockinger B, 2003, Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 197, Pages: 1007-1016, ISSN: 0022-1007

Journal article

Ye P, Price W, Kassiotis G, Kollias G, D'Ercole AJet al., 2003, Tumor necrosis factor-α regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice, JOURNAL OF NEUROSCIENCE RESEARCH, Vol: 71, Pages: 721-731, ISSN: 0360-4012

Journal article

Barthlott T, Kassiotis G, Stockinger B, 2003, T cell regulation as a side effect of homeostasis and competition, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 197, Pages: 451-460, ISSN: 0022-1007

Journal article

Kassiotis G, Garcia S, Simpson E, Stockinger Bet al., 2002, Impairment of immunological memory in the absence of MHC despite survival of memory T cells, NATURE IMMUNOLOGY, Vol: 3, Pages: 244-250, ISSN: 1529-2908

Journal article

Kollias G, Kontoyiannis D, Douni E, Kassiotis Get al., 2002, The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies., Curr Dir Autoimmun, Vol: 5, Pages: 30-50, ISSN: 1422-2132

Journal article

Kassiotis G, Kranidioti K, Kollias G, 2001, Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness, JOURNAL OF NEUROIMMUNOLOGY, Vol: 119, Pages: 239-247, ISSN: 0165-5728

Journal article

Stockinger B, Barthlott T, Kassiotis G, 2001, T cell regulation: a special job or everyone's responsibility?, NATURE IMMUNOLOGY, Vol: 2, Pages: 757-758, ISSN: 1529-2908

Journal article

Kassiotis G, Kollias G, 2001, TNF and receptors in organ-specific autoimmune disease: multi-layered functioning mirrored in animal models, JOURNAL OF CLINICAL INVESTIGATION, Vol: 107, Pages: 1507-1508, ISSN: 0021-9738

Journal article

Kassiotis G, Kollias G, 2001, Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: Implications for pathogenesis and therapy of autoimmune demyelination, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 193, Pages: 427-434, ISSN: 0022-1007

Journal article

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