Imperial College London
Alternate

ProfessorGeorgiosKassiotis

Faculty of Medicine, Department of Infectious Disease

Professor of Retrovirology
 
 
 
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Contact

 

g.kassiotis Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Uchil:2019:10.1016/j.chom.2018.11.011,
author = {Uchil, PD and Pi, R and Haugh, KA and Ladinsky, MS and Ventura, JD and Barrett, BS and Santiago, ML and Bjorkman, PJ and Kassiotis, G and Sewald, X and Mothes, W},
doi = {10.1016/j.chom.2018.11.011},
journal = {Cell Host and Microbe},
pages = {87--100.e10},
title = {A protective role for the Lectin CD169/Siglec-1 against a pathogenic murine retrovirus},
url = {http://dx.doi.org/10.1016/j.chom.2018.11.011},
volume = {25},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Lymph- and blood-borne retroviruses exploit CD169/Siglec-1-mediated capture by subcapsular sinus and marginal zone metallophilic macrophages for trans-infection of permissive lymphocytes. However, the impact of CD169-mediated virus capture on retrovirus dissemination and pathogenesis in vivo is unknown. In a murine model of the splenomegaly-inducing retrovirus Friend virus complex (FVC) infection, we find that while CD169 promoted draining lymph node infection, it limited systemic spread to the spleen. At the spleen, CD169-expressing macrophages captured incoming blood-borne retroviruses and limited their spread to the erythroblasts in the red pulp where FVC manifests its pathogenesis. CD169-mediated retroviral capture activated conventional dendritic cells 1 (cDC1s) and promoted cytotoxic CD8+ T cell responses, resulting in efficient clearing of FVC-infected cells. Accordingly, CD169 blockade led to higher viral loads and accelerated death in susceptible mouse strains. Thus, CD169 plays a protective role during FVC pathogenesis by reducing viral dissemination to erythroblasts and eliciting an effective cytotoxic T lymphocyte response via cDC1s.
AU  - Uchil,PD
AU  - Pi,R
AU  - Haugh,KA
AU  - Ladinsky,MS
AU  - Ventura,JD
AU  - Barrett,BS
AU  - Santiago,ML
AU  - Bjorkman,PJ
AU  - Kassiotis,G
AU  - Sewald,X
AU  - Mothes,W
DO  - 10.1016/j.chom.2018.11.011
EP  - 100
PY  - 2019///
SN  - 1931-3128
SP  - 87
TI  - A protective role for the Lectin CD169/Siglec-1 against a pathogenic murine retrovirus
T2  - Cell Host and Microbe
UR  - http://dx.doi.org/10.1016/j.chom.2018.11.011
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30595553
UR  - http://hdl.handle.net/10044/1/71477
VL  - 25
ER  -
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