Imperial College London
Alternate

ProfessorGeorgiosKassiotis

Faculty of Medicine, Department of Infectious Disease

Professor of Retrovirology
 
 
 
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Contact

 

g.kassiotis Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Merkenschlager:2019:10.1182/blood-2018-11-885467,
author = {Merkenschlager, J and Eksmond, U and Danelli, L and Attig, J and Young, GR and Nowosad, C and Tolar, P and Kassiotis, G},
doi = {10.1182/blood-2018-11-885467},
journal = {Blood},
pages = {1108--1118},
title = {MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells},
url = {http://dx.doi.org/10.1182/blood-2018-11-885467},
volume = {133},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Best known for presenting antigenic peptides to CD4+ T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, as well as in malignant B cells. Initiation of MHC II expression early during bone marrow B-cell development limited the occupancy of cycling compartments by promoting differentiation, thus regulating the numerical output of B cells. MHC II deficiency preserved stem cell characteristics in developing pro-B cells in vivo, and ectopic MHC II expression accelerated hematopoietic stem cell differentiation in vitro. Moreover, MHC II expression restrained growth of murine B-cell leukemia cell lines in vitro and in vivo, independently of CD4+ T-cell surveillance. Our results highlight an important cell-intrinsic contribution of MHC II expression to establishing the differentiated B-cell phenotype.
AU  - Merkenschlager,J
AU  - Eksmond,U
AU  - Danelli,L
AU  - Attig,J
AU  - Young,GR
AU  - Nowosad,C
AU  - Tolar,P
AU  - Kassiotis,G
DO  - 10.1182/blood-2018-11-885467
EP  - 1118
PY  - 2019///
SN  - 1528-0020
SP  - 1108
TI  - MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells
T2  - Blood
UR  - http://dx.doi.org/10.1182/blood-2018-11-885467
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000461506600015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://ashpublications.org/blood/article/133/10/1108/272752/MHC-class-II-cell-autonomously-regulates-self
UR  - http://hdl.handle.net/10044/1/71682
VL  - 133
ER  -
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