Imperial College London
Alternate

ProfessorGeorgiosKassiotis

Faculty of Medicine, Department of Infectious Disease

Professor of Retrovirology
 
 
 
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Contact

 

g.kassiotis Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dittmer:2019:femsre/fuz012,
author = {Dittmer, U and Sutter, K and Kassiotis, G and Zelinskyy, G and Bánki, Z and Stoiber, H and Santiago, ML and Hasenkrug, KJ},
doi = {femsre/fuz012},
journal = {FEMS Microbiology Reviews},
pages = {435--456},
title = {Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity},
url = {http://dx.doi.org/10.1093/femsre/fuz012},
volume = {43},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Approximately 4.4% of the human genome is comprised of endogenous retroviral sequences, a record of an evolutionary battle between man and retroviruses. Much of what we know about viral immunity comes from studies using mouse models. Experiments using the Friend virus (FV) model have been particularly informative in defining highly complex anti-retroviral mechanisms of the intrinsic, innate and adaptive arms of immunity. FV studies have unraveled fundamental principles about how the immune system controls both acute and chronic viral infections. They led to a more complete understanding of retroviral immunity that begins with cellular sensing, production of type 1 interferons, and the induction of intrinsic restriction factors. Novel mechanisms have been revealed, which demonstrate that these earliest responses affect not only virus replication, but also subsequent innate and adaptive immunity. This review on FV immunity not only surveys the complex host responses to a retroviral infection from acute infection to chronicity, but also highlights the many feed-back mechanisms that regulate and counter-regulate the various arms of the immune system. In addition, the discovery of molecular mechanisms of immunity in this model have led to therapeutic interventions with implications for HIV cure and vaccine development.
AU  - Dittmer,U
AU  - Sutter,K
AU  - Kassiotis,G
AU  - Zelinskyy,G
AU  - Bánki,Z
AU  - Stoiber,H
AU  - Santiago,ML
AU  - Hasenkrug,KJ
DO  - femsre/fuz012
EP  - 456
PY  - 2019///
SN  - 0168-6445
SP  - 435
TI  - Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
T2  - FEMS Microbiology Reviews
UR  - http://dx.doi.org/10.1093/femsre/fuz012
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31087035
UR  - https://academic.oup.com/femsre/article/43/5/435/5489187
UR  - http://hdl.handle.net/10044/1/71467
VL  - 43
ER  -
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