Imperial College London
Alternate

ProfessorGeorgiosKassiotis

Faculty of Medicine, Department of Infectious Disease

Professor of Retrovirology
 
 
 
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Contact

 

g.kassiotis Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Toboso-Navasa:2020:10.1084/jem.20191933,
author = {Toboso-Navasa, A and Gunawan, A and Morlino, G and Nakagawa, R and Taddei, A and Damry, D and Patel, Y and Chakravarty, P and Janz, M and Kassiotis, G and Brink, R and Eilers, M and Calado, DP},
doi = {10.1084/jem.20191933},
journal = {J Exp Med},
title = {Restriction of memory B cell differentiation at the germinal center B cell positive selection stage.},
url = {http://dx.doi.org/10.1084/jem.20191933},
volume = {217},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Memory B cells (MBCs) are key for protection from reinfection. However, it is mechanistically unclear how germinal center (GC) B cells differentiate into MBCs. MYC is transiently induced in cells fated for GC expansion and plasma cell (PC) formation, so-called positively selected GC B cells. We found that these cells coexpressed MYC and MIZ1 (MYC-interacting zinc-finger protein 1 [ZBTB17]). MYC and MIZ1 are transcriptional activators; however, they form a transcriptional repressor complex that represses MIZ1 target genes. Mice lacking MYC-MIZ1 complexes displayed impaired cell cycle entry of positively selected GC B cells and reduced GC B cell expansion and PC formation. Notably, absence of MYC-MIZ1 complexes in positively selected GC B cells led to a gene expression profile alike that of MBCs and increased MBC differentiation. Thus, at the GC positive selection stage, MYC-MIZ1 complexes are required for effective GC expansion and PC formation and to restrict MBC differentiation. We propose that MYC and MIZ1 form a module that regulates GC B cell fate.
AU  - Toboso-Navasa,A
AU  - Gunawan,A
AU  - Morlino,G
AU  - Nakagawa,R
AU  - Taddei,A
AU  - Damry,D
AU  - Patel,Y
AU  - Chakravarty,P
AU  - Janz,M
AU  - Kassiotis,G
AU  - Brink,R
AU  - Eilers,M
AU  - Calado,DP
DO  - 10.1084/jem.20191933
PY  - 2020///
TI  - Restriction of memory B cell differentiation at the germinal center B cell positive selection stage.
T2  - J Exp Med
UR  - http://dx.doi.org/10.1084/jem.20191933
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32407433
VL  - 217
ER  -
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