Imperial College London
Dr Geoffrey Lockwood

DrGeoffreyLockwood

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

g.lockwood

 
 
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Location

 

X112Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fiorentino:2019:10.1111/jocs.14044,
author = {Fiorentino, F and Jaaly, EA and Durham, AL and Adcock, IM and Lockwood, G and Rogers, C and Ascione, R and Reeves, BC and Angelini, GD},
doi = {10.1111/jocs.14044},
journal = {Journal of Cardiac Surgery},
pages = {385--399},
title = {Low-frequency ventilation during cardiopulmonary bypass for lung protection: A randomized controlled trial},
url = {http://dx.doi.org/10.1111/jocs.14044},
volume = {34},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Pulmonary dysfunction is a common complication in patients undergoing heart surgery. Current clinical practice does not include any specific strategy for lung protection. To compare the anti-inflammatory effects of low-frequency ventilation (LFV), as measured by nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) p65 pathway activation, for the entire cardiopulmonary bypass (CPB) vs both lungs left collapsed in patients undergoing coronary artery bypass grafting (CABG). METHODS: Two groups parallel randomized controlled trial. The primary outcome was inflammation measured by NF-κB p65 activation in pre- and post-CPB lung biopsies. Secondary outcomes were additional inflammatory markers in both biopsy tissue and blood. RESULTS: Thirty-seven patients were randomly allocated to LFV (18) and to both lungs left collapsed (19). The mean concentration of NF-κB p65 in the biopsies before chest closure (adjusted for pre-CPB concentration) was higher in the LFV group compared to both lungs left collapsed group but this was not significant (0.102, 95% confidence interval, -0.022 to 0.226, P = 0.104). There were no significant differences between groups in the other inflammatory markers measured in tissue and blood. CONCLUSIONS: In patients undergoing elective CABG, the use of LFV during CPB when compared to both lungs left collapsed does not seem to reduce inflammation in lung biopsies and blood.
AU  - Fiorentino,F
AU  - Jaaly,EA
AU  - Durham,AL
AU  - Adcock,IM
AU  - Lockwood,G
AU  - Rogers,C
AU  - Ascione,R
AU  - Reeves,BC
AU  - Angelini,GD
DO  - 10.1111/jocs.14044
EP  - 399
PY  - 2019///
SN  - 0886-0440
SP  - 385
TI  - Low-frequency ventilation during cardiopulmonary bypass for lung protection: A randomized controlled trial
T2  - Journal of Cardiac Surgery
UR  - http://dx.doi.org/10.1111/jocs.14044
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31045289
UR  - http://hdl.handle.net/10044/1/69522
VL  - 34
ER  -
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