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@article{Maertens:2010:10.1038/emboj.2010.129,
author = {Maertens, GN and El, Messaoudi-Aubert S and Elderkin, S and Hiom, K and Peters, G},
doi = {10.1038/emboj.2010.129},
journal = {EMBO Journal},
pages = {2553--2565},
title = {Ubiquitinspecific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor},
url = {http://dx.doi.org/10.1038/emboj.2010.129},
volume = {29},
year = {2010}
}

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TY  - JOUR
AB  - An important facet of transcriptional repression by Polycomb repressive complex 1 (PRC1) is the monoubiquitination of histone H2A by the combined action of the Posterior sex combs (Psc) and Sex combs extra (Sce) proteins. Here, we report that two ubiquitinspecific proteases, USP7 and USP11, copurify with human PRC1type complexes through direct interactions with the Psc orthologues MEL18 and BMI1, and with other PRC1 components. Ablation of either USP7 or USP11 in primary human fibroblasts results in derepression of the INK4a tumour suppressor accompanied by loss of PRC1 binding at the locus and a senescencelike proliferative arrest. Mechanistically, USP7 and USP11 regulate the ubiquitination status of the Psc and Sce proteins themselves, thereby affecting their turnover and abundance. Our results point to a novel function for USPs in the regulation and function of Polycomb complexes.
AU  - Maertens,GN
AU  - El,Messaoudi-Aubert S
AU  - Elderkin,S
AU  - Hiom,K
AU  - Peters,G
DO  - 10.1038/emboj.2010.129
EP  - 2565
PY  - 2010///
SN  - 0261-4189
SP  - 2553
TI  - Ubiquitinspecific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
T2  - EMBO Journal
UR  - http://dx.doi.org/10.1038/emboj.2010.129
UR  - http://hdl.handle.net/10044/1/33149
VL  - 29
ER  -

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