Publications
518 results found
Taylor GP, Hall SE, Navarrete S, et al., 1999, Effect of lamivudine on human T-cell leukemia virus type 1 (HTLV-1) DNA copy number, T-cell phenotype, and anti-tax cytotoxic T-cell frequency in patients with HTLV-1-associated myelopathy, JOURNAL OF VIROLOGY, Vol: 73, Pages: 10289-10295, ISSN: 0022-538X
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- Citations: 97
Taylor GP, 1999, The Epidemiology and Clinical Impact of HTLV Infection in Europe, Aids Reviews, Vol: 1, Pages: 195-204, ISSN: 1698-6997
Clarke JR, Braganza R, Mirza A, et al., 1999, Rapid development of genotypic resistance to lamivudine when combined with zidovudine in pregnancy, JOURNAL OF MEDICAL VIROLOGY, Vol: 59, Pages: 364-368, ISSN: 0146-6615
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- Citations: 30
Taylor GP, Tosswill JHC, Matutes E, et al., 1999, Prospective study of HTLV-I infection in an initially asymptomatic cohort, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 22, Pages: 92-100, ISSN: 1077-9450
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- Citations: 66
Taylor GP, Lyall EGH, Tudor-Williams G, et al., 1999, Labour care of women with HIV infection (multiple letters) [3], British Medical Journal, Vol: 319, Pages: 381-382, ISSN: 0959-8146
Taylor GP, Lyall EGH, Tudor-Williams G, et al., 1999, Labour care of women with HIV infection - Article did not highlight current guidelines, BRITISH MEDICAL JOURNAL, Vol: 319, Pages: 381-382, ISSN: 0959-8138
Bobkova MR, Detkova NV, Buravtsova EV, et al., 1999, Low prevalence of HTLV-I/II infection among HIV-1-infected injecting drug users in Russia, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 21, Pages: 354-354, ISSN: 1077-9450
Louisirirotchanakul S, Beddows S, Cheingsong R, et al., 1999, Role of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailand, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 21, Pages: 259-265, ISSN: 1525-4135
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- Citations: 15
Taylor GP, Lyall EGH, Mercey D, et al., 1999, British HIVAssociation guidelines for prescribing antiretroviral therapy in pregnancy (1998), SEXUALLY TRANSMITTED INFECTIONS, Vol: 75, Pages: 90-97, ISSN: 1368-4973
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- Citations: 19
Jeffery KJM, Usuku K, Hall SE, et al., 1999, HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 96, Pages: 3848-3853, ISSN: 0027-8424
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- Citations: 322
Law AW, Nightingale S, Taylor GP, et al., 1998, Gene expression in Human T-cell leukaemia virus-I-infected patients offers new prospects for therapy, Blood, Vol: 91, Pages: 2467-2474, ISSN: 0006-4971
Clarke JR, Braganza R, Mirza A, et al., 1998, High frequency of resistance mutations in pregnant women on dual antiretroviral therapy, AIDS, Vol: 12, Pages: S20-S20, ISSN: 0269-9370
Tosswill JHC, Taylor GP, Clewley JP, et al., 1998, Quantification of proviral DNA load in human T-cell leukaemia virus type I infections, JOURNAL OF VIROLOGICAL METHODS, Vol: 75, Pages: 21-26, ISSN: 0166-0934
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- Citations: 32
Jungmann E, Mohan D, Mercey D, et al., 1998, Outcome of HIV-1 positive pregnancies in London since the introduction of the ACTG 076 protocol: a retrospective analysis., AIDS, Vol: 12, Pages: S96-S96, ISSN: 0269-9370
Taylor GP, 1998, Pathogenesis and treatment of HTLV-I associated myelopathy, SEXUALLY TRANSMITTED INFECTIONS, Vol: 74, Pages: 316-322, ISSN: 1368-4973
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- Citations: 19
Salemi M, Vandamme AM, Gradozzi C, et al., 1998, Evolutionary rate and genetic heterogeneity of human T-cell lymphotropic virus type II (HTLV-II) using isolates from European injecting drug users, JOURNAL OF MOLECULAR EVOLUTION, Vol: 46, Pages: 602-611, ISSN: 0022-2844
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- Citations: 36
Lau A, Nightingale S, Taylor GP, et al., 1998, Enhanced <i>MDR1</i> gene expression in human T-cell leukemia virus-I-infected patients offers new prospects for therapy, BLOOD, Vol: 91, Pages: 2467-2474, ISSN: 0006-4971
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- Citations: 27
Ait-Khaled M, Lyall EGH, Stainsby C, et al., 1998, Intrapartum mucosal exposure to human immunodeficiency virus type 1 (HIV-1) of infants born to HIV-1-infected mothers correlates with maternal plasma virus burden, JOURNAL OF INFECTIOUS DISEASES, Vol: 177, Pages: 1097-1100, ISSN: 0022-1899
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- Citations: 22
Killick S, Matutes E, Lo S, et al., 1998, Teaching cases from the Royal Marsden Hospital. Case 16: T-cell non Hodgkin's lymphoma associated with hypercalcaemia in a black Caribbean., Leuk Lymphoma, Vol: 29, Pages: 211-215, ISSN: 1042-8194
Lyall EGH, Stainsby C, Taylor GP, et al., 1998, Review of uptake of interventions to reduce mother to child transmission of HIV by women aware of their HIV status, BRITISH MEDICAL JOURNAL, Vol: 316, Pages: 268-270, ISSN: 0959-8138
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- Citations: 13
Wright AM, Taylor GP, Smith JR, 1997, Screening for human immunodeficiency virus (HIV) infection in pregnancy, Contemporary Reviews in Obstetrics and Gynaecology, Vol: 9, Pages: 269-274, ISSN: 0953-9182
As the prevalence of HIV infection in women of reproductive age continues to increase, all healthcare workers involved in looking after pregnant women will soon be expected to have, at least, a working knowledge of the issues involved. This will allow known HIV seropositive women to be given accurate information on the risk of transmission and interventions available to reduce the risk to their baby. It will also ensure that women who are considering HIV screening in pregnancy will be informed of the advantages of knowing if they have HIV infection rather than remaining in ignorance. This article argues that the benefits of proven interventions which decrease vertical transmission and improve maternal health outweigh the potential social and psychological disadvantages of knowing that one is HIV positive. It concludes that antenatal testing confers important benefits to the positive woman of knowing her status and that in the future HIV testing should become part of the routine antenatal infection screen.
Vandamme A, Van Laethem K, Liu H, et al., 1997, Use of a generic polymerase chain reaction assay detecting human Tâlymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology, Journal of Medical Virology, Vol: 52, Pages: 1-7, ISSN: 0146-6615
Vandamme AM, Van Laethem K, Liu HF, et al., 1997, Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology., J Med Virol, Vol: 52, Pages: 1-7, ISSN: 0146-6615
In countries with a low prevalence of human T-lymphotropic virus (HTLV) infection, indeterminate HTLV serologies are a major problem in blood bank screening because of the uncertainties about infection in these cases. The recent discovery of two new types of simian T-lymphotropic viruses (STLV), which give an HTLV-indeterminate serology, raises the question whether indeterminate serologies in humans may be linked to new types of HTLV. Starting from a Tax sequence alignment of all available primate T-cell lymphotropic virus strains (PTLV), including the two new types STLV-PH969 and STLV-PP1664, we developed generic and type-specific nested polymerase chain reactions (PCRs). The generic PCR proved to be highly sensitive and cross-reactive for all four types of PTLV, while the discriminatory PCRs had a high sensitivity and a specificity of 100%. There was no cross-reactivity with human immunodeficiency virus (HIV), ensuring correct interpretation of results from coinfected patients. Among the 77 serologically indeterminate samples tested, 6 were found to be HTLV-1 PCR positive and 1 was HTLV-II PCR positive. Sequencing of one of the HTLV-I PCR positives excluded PCR contamination, and revealed a divergent type of HTLV-I. The majority of the seroindeterminate samples (91%) were however HTLV-PCR negative, and no new types of HTLV were found. This new assay can identify otherwise undetected HTLV-I or HTLV-II infections and is a useful tool of screening for new types of HTLV among seroindeterminate samples.
Goulder PJR, Sewell AK, Lalloo D, et al., 1997, Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatability leukocyte antigen (HLA) identical sibings with HLA-A*0201 are influenced by epitope mutation, Journal of Experimental and Integrative Medicine, Vol: 185, Pages: 1423-1433, ISSN: 1309-4572
Ali M, Taylor GP, Pitman RJ, et al., 1996, No evidence of antibody to human foamy virus in widespread human populations, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 12, Pages: 1473-1483, ISSN: 0889-2229
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- Citations: 51
, 1996, Seroepidemiology of the human T-cell leukaemia/lymphoma viruses in Europe. The HTLV European Research Network., J Acquir Immune Defic Syndr Hum Retrovirol, Vol: 13, Pages: 68-77, ISSN: 1077-9450
An extensive collaboration of laboratories and investigators has been developed to define the seroprevalence of human T-cell leukaemia/ lymphoma virus type I and II (HTLV-I and -II) infection in Europe. An algorithm for serological screening for HTLV-I and -II infection has been established by consensus. Data from screening almost 4 million subjects, including many unpublished studies, which conform to this algorithm are presented. In extensive studies the seroprevalence of HTL.V-I/II in blood donors is low, ranging from < 1 in 100,000 to 30 in 100,000 donors and is due predominantly to HTLV-I. In antenatal clinics in France and the United Kingdom the seroprevalence of HTLV-I is > 0.2%, but surveillance in this setting has been limited and extensive study of the seroprevalence of HTLV-I/II infection in pregnant women in Europe is urgently required to determine the need for HTLV-I/II antenatal screening. HTLV-I is present in populations who have immigrated to Europe from endemic areas and is spreading into indigenous European populations, particularly through sexual transmission to females. HTLV-II infection is present predominantly amongst IVDU and is usually a coinfection with HIV-I. There are considerable regional differences in HTLV-II seroprevalence.
Harrison P, Ala FA, Milligan DW, et al., 1996, HTLV-I screening in Britain. Failure to screen may be a false economy., BMJ, Vol: 312, Pages: 706-707, ISSN: 0959-8138
Weber JN, Taylor GP, 1996, HTLV-I screening in Britain - Antenatal screening is important, BRITISH MEDICAL JOURNAL, Vol: 312, Pages: 706-706, ISSN: 0959-8138
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- Citations: 3
Daenke S, Kermode AG, Hall SE, et al., 1996, High activated and memory cytotoxic T-cell responses to HTLV-1 in healthy carriers and patients with tropical spastic paraparesis, VIROLOGY, Vol: 217, Pages: 139-146, ISSN: 0042-6822
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- Citations: 81
Sandy CJ, Taylor G, Steiger M, et al., 1996, HTLV-I associated uveitis: A report of two cases, EYE, Vol: 10, Pages: 521-522, ISSN: 0950-222X
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- Citations: 5
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