Imperial College London
Alternate

Professor Graham P Taylor

Faculty of Medicine, Department of Infectious Disease

Professor of Human Retrovirology
 
 
 
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Contact

 

+44 (0)20 7594 3910g.p.taylor Website

 
 
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Location

 

443Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rosadas:2020:10.1371/journal.pntd.0008761,
author = {Rosadas, C and Assone, T and Yamashita, M and Adonis, A and Puccioni-Sohler, M and Santos, M and Paiva, A and Casseb, J and Oliveira, ACP and Taylor, GP},
doi = {10.1371/journal.pntd.0008761},
journal = {PLoS Neglected Tropical Diseases},
title = {Health state utility values in people living with HTLV-1 and in patients with HAM/TSP: The impact of a neglected disease on the quality of life},
url = {http://dx.doi.org/10.1371/journal.pntd.0008761},
volume = {14},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: HTLV-1 is a neglected sexually transmitted infection despite being the cause of disabling neurological disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is no treatment for this infection and public health policies are essential to reduce its transmission. However, there are no data to support adequate cost-effective analysis in this field. The aim of this study was to obtain health state utility values for individuals with HAM/TSP and HTLV-1 asymptomatic carriers (AC). The impact of both states on quality of life (QoL) is described and compared to other diseases. METHODS: A cross-sectional observational study of 141 individuals infected with HTLV-1 (79 with HAM/TSP and 62 AC) from three Brazilian states (Rio de Janeiro, São Paulo and Alagoas) and from the United Kingdom. Participants completed a validated general health questionnaire (EQ-5D, Euroqol) from which country specific health state utility values are generated. Clinical and epidemiological data were collated. PRINCIPAL FINDINGS: Health state utility value for HAM/TSP was 0.2991. QoL for 130 reported clinical conditions ranges from 0.35 to 0.847. 12% reported their quality of life as worse as death. Low QoL was associated with severity rather than duration of disease with a moderate inverse correlation between QoL and Osame's Motor Disability Score (-0.4933) Patients who are wheelchair dependent had lowest QoL whilst those still walking unaided had the highest. AC also reported impaired QoL (0.7121) compared to general population. CONCLUSION: HTLV-1 and its associated neurological disease has a marked impact on QoL. This study provides robust data to support the development of cost-utility analysis of interventions for HTLV-1.
AU  - Rosadas,C
AU  - Assone,T
AU  - Yamashita,M
AU  - Adonis,A
AU  - Puccioni-Sohler,M
AU  - Santos,M
AU  - Paiva,A
AU  - Casseb,J
AU  - Oliveira,ACP
AU  - Taylor,GP
DO  - 10.1371/journal.pntd.0008761
PY  - 2020///
SN  - 1935-2727
TI  - Health state utility values in people living with HTLV-1 and in patients with HAM/TSP: The impact of a neglected disease on the quality of life
T2  - PLoS Neglected Tropical Diseases
UR  - http://dx.doi.org/10.1371/journal.pntd.0008761
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33064742
UR  - http://hdl.handle.net/10044/1/83391
VL  - 14
ER  -
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