Imperial College London
Alternate

Professor Graham P Taylor

Faculty of Medicine, Department of Infectious Disease

Professor of Human Retrovirology
 
 
 
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Contact

 

+44 (0)20 7594 3910g.p.taylor Website

 
 
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Location

 

443Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Edhom:2021:10.1007/s13365-020-00932-2,
author = {Edhom, KA and Lidman, C and Granberg, T and Taylor, GP and Paucar, M},
doi = {10.1007/s13365-020-00932-2},
journal = {Journal of NeuroVirology},
pages = {345--347},
title = {Expanding the etiologic spectrum of spastic ataxia syndrome: chronic infection with human T lymphotropic virus type 1},
url = {http://dx.doi.org/10.1007/s13365-020-00932-2},
volume = {27},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Infection with human T cell lymphotropic virus type 1 (HTLV-1) is in most cases indolent; however, some patients develop adult T cell leukemia, associated with poor prognosis, or the highly disabling and incurable HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) (Verdonck et al. 2007; Cooper et al. 2009). HTLV-1 is an endemic infection in Southern Japan, Iran, South America, the Caribbean basin, West Africa, and among aborigines in Australia (Verdonck et al. 2007). There are no established biomarkers to predict complications in HTLV-1; however, the percentage of peripheral blood mononuclear cells (PBMCs) harboring the provirus, called proviral load (PVL), and beta-2 microglobulin (β2M) in serum are surrogate biomarkers. Associations with neurological syndromes other than HAM/TSP have been claimed, including neuropathy, motor neuron disease (Araujo et al. 2019), as well as cerebellar ataxia (Iwasaki 4,5,6,; Kira et al. 1993; Gracia et al. 1995; e-1 to e-6). In the majority of reported cases, ataxia occurred in Japanese patients with HAM/TSP (Iwasaki 1990; Iwanaga 1993; Kira et al. 1993; e1, e-2, e-4, e-6). Here, we present an Iranian HTLV-1 positive patient with a cerebellar syndrome, elevated β2M in serum, and elevated neopterin and CXCL10 in cerebrospinal fluid (CSF).
AU  - Edhom,KA
AU  - Lidman,C
AU  - Granberg,T
AU  - Taylor,GP
AU  - Paucar,M
DO  - 10.1007/s13365-020-00932-2
EP  - 347
PY  - 2021///
SN  - 1355-0284
SP  - 345
TI  - Expanding the etiologic spectrum of spastic ataxia syndrome: chronic infection with human T lymphotropic virus type 1
T2  - Journal of NeuroVirology
UR  - http://dx.doi.org/10.1007/s13365-020-00932-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33751488
UR  - http://hdl.handle.net/10044/1/87278
VL  - 27
ER  -
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